ChemInform Abstract: A Metal-free Decarboxylative Cyclization from Natural α-Amino Acids to Construct Pyridine Derivatives.

ChemInform ◽  
2011 ◽  
Vol 42 (29) ◽  
pp. no-no
Author(s):  
Qiang Wang ◽  
Changfeng Wan ◽  
Yang Gu ◽  
Jintang Zhang ◽  
Lingfeng Gao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pyridine Derivatives ◽  
Metal Free ◽  
Decarboxylative Cyclization

A metal-free decarboxylative cyclization from natural α-amino acids to construct pyridine derivatives

2011 ◽  
Vol 13 (3) ◽  
pp. 578 ◽  
Author(s):  
Qiang Wang ◽  
Changfeng Wan ◽  
Yang Gu ◽  
Jintang Zhang ◽  
Lingfeng Gao ◽  
...  
Keyword(s):  
Amino Acids ◽  
Pyridine Derivatives ◽  
Metal Free ◽  
Decarboxylative Cyclization

scholarly journals The synthesis of imidazo[1,5-a]quinolinesviaa decarboxylative cyclization under metal-free conditions

RSC Advances ◽  
2018 ◽  
Vol 8 (41) ◽  
pp. 23058-23065 ◽  
Author(s):  
Zicong Yan ◽  
Changfeng Wan ◽  
Yu Yang ◽  
Zhenggen Zha ◽  
Zhiyong Wang
Keyword(s):  
Amino Acids ◽  
Metal Free ◽  
Decarboxylative Cyclization

An iodine-mediated decarboxylative cyclization was developed from α-amino acids and 2-methyl quinolines under metal-free conditions, affording a variety of imidazo[1,5-a]quinolines with moderate to good yields.

Metal-Free Decarboxylative Cyclization/Ring Expansion: Construction of Five-, Six-, and Seven-Membered Heterocycles from 2-Alkynyl Benzaldehydes and Cyclic Amino Acids

2015 ◽  
Vol 127 (33) ◽  
pp. 9700-9703 ◽  
Author(s):  
Srinivas Samala ◽  
Gajendra Singh ◽  
Ravi Kumar ◽  
Ravi Sankar Ampapathi ◽  
Bijoy Kundu
Keyword(s):  
Amino Acids ◽  
Ring Expansion ◽  
Metal Free ◽  
Decarboxylative Cyclization ◽  
Cyclic Amino Acids

scholarly journals Morpholin-2-one Derivatives via Intramolecular Acid-Catalyzed Hydroamination

Synthesis ◽  
2019 ◽  
Vol 51 (07) ◽  
pp. 1643-1648 ◽  
Author(s):  
David Knight ◽  
Thomas Wirth ◽  
Abdul Hadi Aldmairi
Keyword(s):  
Amino Acids ◽  
Catalytic Amount ◽  
Practical Method ◽  
Trifluoromethanesulfonic Acid ◽  
Reaction Conditions ◽  
Available N ◽  
Metal Free ◽  
Acid Catalyzed

Substituted morpholin-2-one derivatives were readily obtained in two steps starting from commercially available N-protected amino acids. In a metal-free and practical method, a catalytic amount of trifluoromethanesulfonic acid was sufficient to generate morpholinones under mild reaction conditions in an intramolecular hydroamination reaction in good to excellent yields.

Transition Metal‐Free, Base‐Induced Arylation of Amino Acids: Synthesis of N ‐( para ‐Substituted phenyl)amino‐2‐carboxylic acids

2020 ◽  
Vol 5 (28) ◽  
pp. 8644-8648 ◽  
Author(s):  
Adejoke D. Osinubi ◽  
Josephat U. Izunobi ◽  
Olayinka T. Asekun ◽  
Oluwole B. Familoni ◽  
Xiaoguang Bao
Keyword(s):  
Amino Acids ◽  
Transition Metal ◽  
Carboxylic Acids ◽  
Free Base ◽  
Metal Free

Iodine mediated oxidative cross coupling of 2-aminopyridine and aromatic terminal alkyne: a practical route to imidazo[1,2-a]pyridine derivatives

2019 ◽  
Vol 17 (26) ◽  
pp. 6441-6449 ◽  
Author(s):  
Surya Kanta Samanta ◽  
Mrinal K. Bera
Keyword(s):  
Transition Metal ◽  
Oxidative Coupling ◽  
Cross Coupling ◽  
Terminal Alkyne ◽  
Pyridine Derivatives ◽  
Metal Free

A novel, transition-metal free route leading to imidazo[1,2-a]pyridine derivatives via iodine mediated oxidative coupling between 2-aminopyridine and aromatic terminal alkyne has been demonstrated.

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