ChemInform Abstract: Total Synthesis of Rutaecarpine and Analogues by Tandem Azido Reductive Cyclization Assisted by Microwave Irradiation.

ChemInform ◽  
2011 ◽  
Vol 42 (19) ◽  
pp. no-no
Author(s):  
Ahmed Kamal ◽  
M. Kashi Reddy ◽  
T. Srinivasa Reddy ◽  
Leonardo Silva Santos ◽  
Nagula Shankaraiah
Keyword(s):  
Microwave Irradiation ◽  
Total Synthesis ◽  
Reductive Cyclization

Total Synthesis of Rutaecarpine and Analogues by Tandem Azido Reductive Cyclization Assisted by Microwave Irradiation

Synlett ◽  
2010 ◽  
Vol 2011 (01) ◽  
pp. 61-64 ◽  
Author(s):  
Ahmed Kamal ◽  
Nagula Shankaraiah ◽  
M. Reddy ◽  
T. Reddy ◽  
Leonardo Santos
Keyword(s):  
Microwave Irradiation ◽  
Total Synthesis ◽  
Reductive Cyclization

ChemInform Abstract: Formal Total Synthesis of (-)-Dendrobine Using Zirconium-Promoted Reductive Cyclization.

ChemInform ◽  
2010 ◽  
Vol 26 (14) ◽  
pp. no-no
Author(s):  
N. UESAKA ◽  
F. SAITOH ◽  
M. MORI ◽  
M. SHIBASAKI ◽  
K. OKAMURA ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Reductive Cyclization

The Catalytic Alkylative Desymmetrization of Anhydrides in a Formal Synthesis of Ionomycin

Synthesis ◽  
2018 ◽  
Vol 50 (22) ◽  
pp. 4343-4350
Author(s):  
Tomislav Rovis ◽  
Kevin Oberg ◽  
Brian Cochran ◽  
Matthew Cook
Keyword(s):  
Total Synthesis ◽  
Reductive Cyclization ◽  
Formal Synthesis

The catalytic desymmetrization of anhydrides with zinc reagents provides access to deoxypolypropionate and polypropionate synthons. A synthesis of ionomycin was pursued in which three of the four fragments were assembled using this methodology. Two of the strategies (enol silane/oxocarbenium coupling and reductive cyclization) were not successful at installing the C23 stereocenter, but this stereochemical issue was overcome through a reduction/SN2 approach. In addition to the synthesis of a protected diastereomer of ionomycin, the synthesis of a C17–C32 fragment constitutes a formal total synthesis.

Asymmetric Reductive Cyclization. Total Synthesis of (−)-C10-Desmethyl Arteannuin B

1996 ◽  
Vol 61 (10) ◽  
pp. 3240-3244 ◽  
Author(s):  
Michael Schwaebe ◽  
R. Daniel Little
Keyword(s):  
Total Synthesis ◽  
Reductive Cyclization

A regioselective facile synthesis of furo[3,4-b]carbazolones: application to the total synthesis of mafaicheenamine E and claulansine D

2015 ◽  
Vol 13 (22) ◽  
pp. 6344-6352 ◽  
Author(s):  
Dipakranjan Mal ◽  
Joyeeta Roy
Keyword(s):  
Total Synthesis ◽  
Reductive Cyclization ◽  
Facile Synthesis

1-Hydroxycarbazole-2,3-dicarboxylates have been shown to undergo chemoselective reductive cyclization to furo[3,4-b]carbazolones with LiAlH4.

The total synthesis of (+)-ryanodol. Part IV. Preparation of (+)-ryanodol from (+)-anhydroryanodol

1990 ◽  
Vol 68 (1) ◽  
pp. 186-192 ◽  
Author(s):  
Pierre Deslongchamps ◽  
André Bélanger ◽  
Daniel J. F. Berney ◽  
Hans-Jürg Borschberg ◽  
Robert Brousseau ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Reductive Cyclization

This paper reports the transformation of (+)-anhydroryanodol (6) to (+)-ryanodol (7) by reductive cyclization of lactone epoxide derivatives 9 and 20 (Scheme 4). Keywords: anhydroryanodol, ryanodol, diterpene, synthesis, reductive cyclization.

Total synthesis of protosappanin A and its derivatives via palladium catalyzed ortho C–H activation/C–C cyclization under microwave irradiation

2016 ◽  
Vol 52 (29) ◽  
pp. 5152-5155 ◽  
Author(s):  
Jiaqi Liu ◽  
Xuan Zhou ◽  
Chenglong Wang ◽  
Wanyong Fu ◽  
Wenyi Chu ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Total Synthesis ◽  
Natural Product ◽  
Ring Enlargement ◽  
Palladium Catalyzed

Protosappanin A, a complex natural product with high bioactivity, and 25 of its derivatives were synthesized through an intramolecular ortho C–H activation/C–C cyclization, ring-enlargement and deprotection reaction. C–H activation as the key step was investigated and optimized.

The Art of Total Synthesis of Bioactive Natural Products via Microwaves

2021 ◽  
Vol 25 ◽  
Author(s):  
Sasadhar Majhi
Keyword(s):  
Natural Products ◽  
Microwave Irradiation ◽  
Total Synthesis ◽  
Biological Activities ◽  
Complex Structure ◽  
Reaction Times ◽  
Side Reactions ◽  
Bioactive Natural Products ◽  
Classical Methodology ◽  
Green Technique

: Natural products are the most effective source of potential drug leads. The total synthesis of bioactive natural products plays a crucial role to confirm the hypothetical complex structure of natural products in the laboratory. The total synthesis of rare bioactive natural products is one of the great challenges for the organic synthetic community due to their complex structures, biochemical specificity, and stubborn stereochemistry. Subsequently, the total synthesis is a long process in several cases and it requires a substantial amount of time. Microwave irradiation has emerged as a greener tool in organic methodologies to reduce reaction times from days and hours to minutes and seconds. Moreover, this non-classical methodology increases product yields and purities, improves reproducibility, modifications of selectivity, simplification of work-up methods, and reduces unwanted side reactions. Such beneficial qualities have stimulated this review to cover the application of microwave irradiation in the field of the total synthesis of bioactive natural products for the first time during the last decade. An overview of the use of microwave irradiation, natural sources, structures, and biological activities of secondary metabolites is presented elegantly, focusing on the involvement of at least one or more steps by microwave irradiation as a green technique.

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