ChemInform Abstract: A Convenient Synthetic Route from Isatin N-Mannich Bases to Nitrogen-Containing Derivatives of Isoindigo.

ChemInform ◽  
2011 ◽  
Vol 42 (17) ◽  
pp. no-no
Author(s):  
Andrei V. Bogdanov ◽  
Vladimir F. Mironov ◽  
Lenar I. Musin ◽  
Rashid Z. Musin ◽  
Dmitry B. Krivolapov ◽  
...  
Keyword(s):  
Mannich Bases ◽  
Synthetic Route ◽  
Derivatives Of

A convenient synthetic route from isatin N-Mannich bases to nitrogen-containing derivatives of isoindigo

2010 ◽  
Vol 142 (1) ◽  
pp. 81-85 ◽  
Author(s):  
Andrei V. Bogdanov ◽  
Vladimir F. Mironov ◽  
Lenar I. Musin ◽  
Rashid Z. Musin ◽  
Dmitry B. Krivolapov ◽  
...  
Keyword(s):  
Mannich Bases ◽  
Synthetic Route ◽  
Derivatives Of

ChemInform Abstract: Photo- and Thermochromic Mannich Bases. Derivatives of 2,6-Di-tert- butylphenol and Aromatic ortho-Hydroxyaldehydes.

ChemInform ◽  
2010 ◽  
Vol 24 (9) ◽  
pp. no-no
Author(s):  
V. N. KOMISSAROV ◽  
V. A. KHARLANOV ◽  
L. YU. UKHIN ◽  
E. YU. BULGAREVICH ◽  
V. I. MINKIN
Keyword(s):  
Mannich Bases ◽  
Derivatives Of

A Synthetic Route to Epoxyalkyl β-Laminaribiosides, Especially Suitable for Radiolabeling

1994 ◽  
Vol 47 (9) ◽  
pp. 1805 ◽  
Author(s):  
WM Best ◽  
RV Stick ◽  
DMG Tilbrook
Keyword(s):  
Synthetic Route ◽  
Benzyl Ethers ◽  
Derivatives Of

The major products in the controlled benzylation (NaH/PhCH2Cl) of allyl and but-3-enyl β-D-glucopyranosides were the 2,4,6-tri-O-benzyl ethers. Subsequent glycosidations of these tribenzyl ethers gave derivatives of allyl and but-3-enyl β- laminaribioside, the latter being subsequently transformed into 3,4-epoxybutyl β- laminaribioside.

scholarly journals α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA

2019 ◽  
Vol 15 ◽  
pp. 2524-2533 ◽  
Author(s):  
Shital K Chattopadhyay ◽  
Subhankar Ghosh ◽  
Sarita Sarkar ◽  
Kakali Bhadra
Keyword(s):  
Anticancer Drug ◽  
Hela Cells ◽  
Hydroxamic Acid ◽  
Suberoylanilide Hydroxamic Acid ◽  
Oxygen Species ◽  
Synthetic Route ◽  
Metathesis Reaction ◽  
Cross Metathesis ◽  
Terminal Alkene ◽  
Derivatives Of

An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro derivative is obtained through a cross metathesis reaction between a suitable terminal alkene and N-benzyloxyacrylamide. Some of the didehydro derivatives of SAHA were preliminarily evaluated for anticancer activity towards HeLa cells. The administration of the analogues caused a significant decrease in the proliferation of HeLa cells. Furthermore, one of the analogues showed a maximum cytotoxicity with a minimum GI50 value of 2.5 µg/mL and the generation of reactive oxygen species (ROS) as some apoptotic features.

Modellreaktionen zur Plumbagin-Synthese, 2. Mitteilung 5-Amino-1-naphthol als Startkomponente / Model Reactions for Plumbagin Synthesis, 2nd Communication 5-Amino-1-naphthol as Starting Compound

1987 ◽  
Vol 42 (12) ◽  
pp. 1578-1584 ◽  
Author(s):  
Hans Möhrle ◽  
Hubertus Folttmann
Keyword(s):  
Hydroxy Group ◽  
Mannich Bases ◽  
Starting Compound ◽  
Derivatives Of ◽  
Nitrosylsulfuric Acid ◽  
Model Reactions

AbstractThe aminomethylation of 5-amino-1-naphthol (1) and 5-acetamido-1-naphthol (9) is examined. While the hydrogenolysis of the phenol Mannich bases derived from 1 cannot be accomplished, the derivatives of 9 react easily. The oxidation of the 2-methylphenol compounds 5 and 18 to the corresponding quinones may performed with Fremy's salt. The following transforming of the amino to the hydroxy group by nitrosylsulfuric acid succeeds with small yield only.

scholarly journals Coupling of C-nitro-NH-azoles with arylboronic acids. A route to N-aryl-C-nitroazoles

2013 ◽  
Vol 9 ◽  
pp. 1517-1525 ◽  
Author(s):  
Marta K Kurpet ◽  
Aleksandra Dąbrowska ◽  
Małgorzata M Jarosz ◽  
Katarzyna Kajewska-Kania ◽  
Nikodem Kuźnik ◽  
...  
Keyword(s):  
Sodium Hydroxide ◽  
Coupling Reaction ◽  
Copper Salt ◽  
Synthetic Route ◽  
Arylboronic Acids ◽  
Derivatives Of

A method for the synthesis of N-aryl-C-nitroazoles is presented. A coupling reaction between variously substituted arylboronic acids and 3(5)-nitro-1H-pyrazole catalyzed by copper salt has been carried out in methanol in the presence of sodium hydroxide to afford the desired N-aryl-C-nitroazoles in good yields. This synthetic route has also been successfully applied to obtain N-phenyl derivatives of 4-nitropyrazole, 2-nitroimidazole, 4(5)-nitroimidazole and 3-nitro-1,2,4-triazole.

Synthesis of Some New N-Mannich Bases Derivatives of Phenytoin

2018 ◽  
Vol 11 (2) ◽  
pp. 236
Author(s):  
Sushil R. Mathapati ◽  
Vikas B. Suryawanshi ◽  
Abhay S. Bondge ◽  
Jairaj K. Dawale
Keyword(s):  
Mannich Bases ◽  
Derivatives Of
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