ChemInform Abstract: Palladium-Catalyzed Direct and Regioselective C-H Bond Functionalization/Oxidative Acetoxylation of Indoles.

ChemInform ◽  
2011 ◽  
Vol 42 (16) ◽  
pp. no-no
Author(s):  
Pui Ying Choy ◽  
Chak Po Lau ◽  
Fuk Yee Kwong
Keyword(s):  
Bond Functionalization ◽  
Palladium Catalyzed ◽  
Oxidative Acetoxylation

Theoretical and experimental studies of palladium-catalyzed site-selective C(sp3)−H bond functionalization enabled by transient ligands

2017 ◽  
Author(s):  
Haibo Ge ◽  
Lei Pan ◽  
Piaoping Tang ◽  
Ke Yang ◽  
Mian Wang ◽  
...  
Keyword(s):  
Bond Activation ◽  
Theoretical Calculations ◽  
Experimental Studies ◽  
Bond Functionalization ◽  
Aliphatic Ketones ◽  
Site Selectivity ◽  
Mechanistic Investigation ◽  
Palladium Catalyzed ◽  
Metal Catalyzed ◽  
Site Selective

Transition metal-catalyzed selective C–H bond functionalization enabled by transient ligands has become an extremely attractive topic due to its economical and greener characteristics. However, catalytic pathways of this reaction process on unactivated sp<sup>3</sup> carbons of reactants have not been well studied yet. Herein, detailed mechanistic investigation on Pd-catalyzed C(sp<sup>3</sup>)–H bond activation with amino acids as transient ligands has been systematically conducted. The theoretical calculations showed that higher angle distortion of C(sp2)-H bond over C(sp3)-H bond and stronger nucleophilicity of benzylic anion over its aromatic counterpart, leading to higher reactivity of corresponding C(sp<sup>3</sup>)–H bonds; the angle strain of the directing rings of key intermediates determines the site-selectivity of aliphatic ketone substrates; replacement of glycine with β-alanine as the transient ligand can decrease the angle tension of the directing rings. Synthetic experiments have confirmed that β-alanine is indeed a more efficient transient ligand for arylation of β-secondary carbons of linear aliphatic ketones than its glycine counterpart.<br><br>

Palladium-catalyzed allylic C–H oxidation under simple operation and mild conditions

2019 ◽  
Vol 17 (12) ◽  
pp. 3103-3107 ◽  
Author(s):  
Yunlong Guo ◽  
Zengming Shen
Keyword(s):  
Simple System ◽  
Allylic Alcohols ◽  
Bond Functionalization ◽  
Simple Operation ◽  
Mild Conditions ◽  
Palladium Catalyzed

We discovered an effective and simple system (Pd/BQ/air/r.t.) for making allylic alcohols through Pd-catalyzed allylic C–H bond functionalization.

scholarly journals Recent Advances in Palladium-Catalyzed Bridging C–H Activation by Using Alkenes, Alkynes or Diazo Compounds as Bridging Reagents

Synthesis ◽  
2020 ◽  
Vol 53 (02) ◽  
pp. 238-254
Author(s):  
Fulin Zhang ◽  
Luoting Xin ◽  
Saihu Liao ◽  
Xueliang Huang ◽  
Yinghua Yu
Keyword(s):  
Bond Distance ◽  
Short Review ◽  
Diazo Compounds ◽  
Bond Functionalization ◽  
Migratory Insertion ◽  
Intramolecular Reactions ◽  
Palladium Catalyzed ◽  
Direct Functionalization ◽  
Intermolecular Reactions ◽  
Metal Catalyzed

AbstractTransition-metal-catalyzed direct inert C–H bond functionalization has attracted much attention over the past decades. However, because of the high strain energy of the suspected palladacycle generated via C–H bond palladation, direct functionalization of a C–H bond less than a three-bond distance from a catalyst center is highly challenging. In this short review, we summarize the advances on palladium-catalyzed bridging C–H activation, in which an inert proximal C–H bond palladation is promoted by the elementary step of migratory insertion of an alkene, an alkyne or a metal carbene intermediate.1 Introduction2 Palladium-Catalyzed Alkene Bridging C–H Activation2.1 Intramolecular Reactions2.2 Intermolecular Reactions3 Palladium-Catalyzed Alkyne Bridging C–H Activation3.1 Intermolecular Reactions3.2 Intramolecular Reactions4 Palladium-Catalyzed Carbene Bridging C–H Activation5 Conclusion and Outlook

ChemInform Abstract: Palladium-Catalyzed Oxidative Acetoxylation of Benzylic C-H Bond Using Bidentate Auxiliary.

ChemInform ◽  
2014 ◽  
Vol 45 (15) ◽  
pp. no-no
Author(s):  
Long Ju ◽  
Jinzhong Yao ◽  
Zaihong Wu ◽  
Zhanxiang Liu ◽  
Yuhong Zhang
Keyword(s):  
Palladium Catalyzed ◽  
Oxidative Acetoxylation

ChemInform Abstract: Palladium-Catalyzed C-H Bond Functionalization with Arylsulfonyl Chlorides.

ChemInform ◽  
2009 ◽  
Vol 40 (29) ◽  
Author(s):  
Xiaodan Zhao ◽  
Elena Dimitrijevic ◽  
Vy M. Dong
Keyword(s):  
Bond Functionalization ◽  
Palladium Catalyzed

scholarly journals Palladium-Catalyzed C(sp3)–H Bond Functionalization of Aliphatic Amines

Chem ◽  
2019 ◽  
Vol 5 (5) ◽  
pp. 1031-1058 ◽  
Author(s):  
Chuan He ◽  
William G. Whitehurst ◽  
Matthew J. Gaunt
Keyword(s):  
Aliphatic Amines ◽  
Bond Functionalization ◽  
Palladium Catalyzed
Sign in / Sign up

Export Citation Format

Share Document