ChemInform Abstract: Synthesis of Highly Substituted Cyclobutane Fused-Ring Systems from N-Vinyl β-Lactams Through a One-Pot Domino Process.

ChemInform ◽  
2010 ◽  
Vol 41 (37) ◽  
pp. no-no
Author(s):  
Lawrence L. W. Cheung ◽  
Andrei K. Yudin
Keyword(s):  
One Pot ◽  
Ring Systems ◽  
Fused Ring

Synthesis of Pyrazolofuropyrazine via One-Pot SNAr Reaction and Intramolecular Direct C–H Arylation

Synthesis ◽  
2018 ◽  
Vol 50 (07) ◽  
pp. 1493-1498 ◽  
Author(s):  
Shinichiro Fuse ◽  
Hiroyuki Nakamura ◽  
Megumi Inaba ◽  
Shinichi Sato ◽  
Manjusha Joshi
Keyword(s):  
Drug Discovery ◽  
Rapid Development ◽  
Ring System ◽  
Biologically Active ◽  
Drug Candidate ◽  
One Pot ◽  
Ring Systems ◽  
Drug Candidates ◽  
Fused Ring ◽  
Snar Reaction

Fused-ring systems containing heterocycles are attractive templates for drug discovery. Biologically active 6-5-5+6 fused-ring systems that possess heterocycles are available, but these require a relatively large number of synthetic steps for preparation. Therefore, pyrazolofuropyrazine was designed as a 6-5-5+6 ring system template that incorporates ready accessibility for drug discovery. Pyrazolofuropyrazines were successfully constructed in only a few steps via one-pot SNAr reaction/intramolecular C–H direct arylation. As a drug candidate, pyrazolofuropyrazine has earned a favorable LogP, although significant biological activity has yet to be established; the ready accessibility of pyrazolofuropyrazine template, however, offers an opportunity for the rapid development of promising new drug candidates.

ChemInform Abstract: 1,4,5,8-Tetraazafulvalenes - A Convenient One-Pot Synthesis and Their Conversion to Fused Ring Systems.

ChemInform ◽  
2010 ◽  
Vol 28 (29) ◽  
pp. no-no
Author(s):  
C. KAEPPLINGER ◽  
R. BECKERT ◽  
W. GUENTHER ◽  
H. GOERLS
Keyword(s):  
One Pot ◽  
Ring Systems ◽  
One Pot Synthesis ◽  
Fused Ring

1,4,5,8-Tetraazafulvalenes – A Convenient One-Pot Synthesis and Their Conversion to Fused Ring Systems

1997 ◽  
Vol 1997 (3) ◽  
pp. 617-622 ◽  
Author(s):  
Christian Käpplinger ◽  
Rainer Beckert ◽  
Wolfgang Günther ◽  
Helmar Görls
Keyword(s):  
One Pot ◽  
Ring Systems ◽  
One Pot Synthesis ◽  
Fused Ring

scholarly journals One-pot three-component synthesis of quinoxaline and phenazine ring systems using Fischer carbene complexes

2010 ◽  
Vol 6 ◽  
Author(s):  
Priyabrata Roy ◽  
Binay Krishna Ghorai
Keyword(s):  
Diels Alder ◽  
Fischer Carbene Complexes ◽  
One Pot ◽  
Carbene Complexes ◽  
Ring Systems ◽  
First Report ◽  
Fischer Carbene ◽  
Carbonyl Derivatives ◽  
Transient Intermediates ◽  
Three Component Coupling

One-pot three-component coupling ofo-alkynylheteroaryl carbonyl derivatives with Fischer carbene complexes and dienophiles leading to the synthesis of quinoxaline and phenazine ring systems has been investigated. This involves the generation of furo[3,4-b]pyrazine and furo[3,4-b]quinoxaline as transient intermediates, which were trapped with Diels–Alder dienophiles. This is the first report on furo[3,4-b]pyrazine intermediates.

Synthesis of Fused Ring Systems with Ring Junction Heteroatoms

2010 ◽  
pp. 889-916
Author(s):  
Alan R. Katritzky ◽  
Christopher A. Ramsden ◽  
John A. Joule ◽  
Viktor V. Zhdankin
Keyword(s):  
Ring Systems ◽  
Ring Junction ◽  
Fused Ring

10.24.5 Product Subclass 5: Pyridazino[1,6-a]indoles and Related Benzo-Fused Ring Systems

2021 ◽  
Author(s):  
P. A. Harris
Keyword(s):  
Ring Systems ◽  
Fused Ring

AbstractThe synthesis of pyridazino[1,6-a]indoles, as well as the related indolo[1,2-b]cinnolines and indolo[2,1-a]phthalazines, are reviewed in this chapter. The most utilized methods to access pyridazino[1,6-a]indoles involve annulation of 1H-indol-1-amine derivatives.

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