ChemInform Abstract: A New Paradigm for Practical Synthesis of Biofunctional Natural Products: Renaissance of Traditional Organic Reactions under Microfluidic Conditions

ChemInform ◽  
2010 ◽  
Vol 41 (30) ◽  
pp. no-no
Author(s):  
Katsunori Tanaka
Keyword(s):  
Natural Products ◽  
Organic Reactions ◽  
New Paradigm ◽  
Practical Synthesis

scholarly journals Non-Enzymatic Desymmetrization Reactions in Aqueous Media

Symmetry ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 720
Author(s):  
Satomi Niwayama
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Functional Groups ◽  
Organic Compounds ◽  
Recent Progress ◽  
Aqueous Media ◽  
Building Blocks ◽  
Organic Reactions ◽  
Environmentally Benign ◽  
Enzymatic Desymmetrization

Symmetric organic compounds are generally obtained inexpensively, and therefore they can be attractive building blocks for the total synthesis of various pharmaceuticals and natural products. The drawback is that discriminating the identical functional groups in the symmetric compounds is difficult. Water is the most environmentally benign and inexpensive solvent. However, successful organic reactions in water are rather limited due to the hydrophobicity of organic compounds in general. Therefore, desymmetrization reactions in aqueous media are expected to offer versatile strategies for the synthesis of a variety of significant organic compounds. This review focuses on the recent progress of desymmetrization reactions of symmetric organic compounds in aqueous media without utilizing enzymes.

Enantio- and diastereocontrolled conversion of chiral epoxides to trans-cyclopropane carboxylates: application to the synthesis of cascarillic acid, grenadamide and l-(−)-CCG-II

2012 ◽  
Vol 10 (34) ◽  
pp. 6987-6994 ◽  
Author(s):  
Pradeep Kumar ◽  
Abhishek Dubey ◽  
Anand Harbindu
Keyword(s):  
Natural Products ◽  
Chiral Epoxides ◽  
Practical Synthesis

A very concise and practical synthesis of cascarillic acid, grenadamide and l-CCG-II, a cyclopropane containing natural products is accomplished employing Wadsworth-Emmons cyclopropanation reaction as key step.

scholarly journals A practical synthesis of long-chain iso-fatty acids (iso-C12–C19) and related natural products

2013 ◽  
Vol 9 ◽  
pp. 1807-1812 ◽  
Author(s):  
Mark B Richardson ◽  
Spencer J Williams
Keyword(s):  
Fatty Acids ◽  
Natural Products ◽  
Selective Reduction ◽  
Isopropyl Group ◽  
Tertiary Alcohols ◽  
Practical Synthesis ◽  
Long Chain

A gram-scale synthesis of terminally-branched iso-fatty acids (iso-C12–C19) was developed commencing with methyl undec-10-enoate (methyl undecylenate) (for iso-C12–C14) or the C15and C16lactones pentadecanolide (for iso-C15–C17) and hexadecanolide (for iso-C18–C19). Central to the approaches outlined is the two-step construction of the terminal isopropyl group through addition of methylmagnesium bromide to the ester/lactones and selective reduction of the resulting tertiary alcohols. Thus, the C12, C17and C18iso-fatty acids were obtained in three steps from commercially-available starting materials, and the remaining C13–C16and C19iso-fatty acids were prepared by homologation or recursive dehomologations of these fatty acids or through intercepting appropriate intermediates. Highlighting the synthetic potential of the iso-fatty acids and various intermediates prepared herein, we describe the synthesis of the natural products (S)-2,15-dimethylpalmitic acid, (S)-2-hydroxy-15-methylpalmitic acid, and 2-oxo-14-methylpentadecane.

scholarly journals Developments of Corey-Chaykovsky in Organic Reactions and Total Synthesis of Natural Products

2016 ◽  
Vol 13 (3) ◽  
pp. 308-333 ◽  
Author(s):  
Majid M. Heravi ◽  
Shima Asadi ◽  
Niousha Nazari ◽  
Boshra Malekzadeh Lashkariani
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Organic Reactions

scholarly journals Rhus vernicifluaStokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Woncheol Choi ◽  
Hyunsik Jung ◽  
Kyungsuk Kim ◽  
Sookyung Lee ◽  
Seongwoo Yoon ◽  
...  
Keyword(s):  
Natural Products ◽  
Advanced Cancer ◽  
Cancer Biology ◽  
Herbal Extract ◽  
Cancer Center ◽  
New Paradigm ◽  
Advanced Cancer Patients ◽  
Compound Screening ◽  
Knowledge Of Cancer

Active anticancer molecules have been searched from natural products; many drugs were developed from either natural products or their derivatives following the conventional pharmaceutical paradigm of drug discovery. However, the advances in the knowledge of cancer biology have led to personalized medicine using molecular-targeted agents which create new paradigm. Clinical benefit is dependent on individual biomarker and overall survival is prolonged through cytostatic rather than cytotoxic effects to cancer cell. Therefore, a different approach is needed from the single lead compound screening model based on cytotoxicity. In our experience, theRhus vernicifluastoke (RVS) extract traditionally used for cancer treatment is beneficial to some advanced cancer patients though it is herbal extract not single compound, and low cytotoxic in vitro. The standardized RVS extract's action mechanisms as well as clinical outcomes are reviewed here. We hope that these preliminary results would stimulate different investigation in natural products from conventional chemicals.

scholarly journals Recent Applications and Developments of Organic Azides in Total Synthesis of Natural Products

2013 ◽  
Vol 8 (7) ◽  
pp. 1934578X1300800 ◽  
Author(s):  
Hiroki Tanimoto ◽  
Kiyomi Kakiuchi
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Chemical Biology ◽  
Organic Reactions ◽  
Bioactive Molecules ◽  
Preparation Methods ◽  
Organic Azides ◽  
Agricultural Areas

Organic azides have been exploited since their discovery because of their high reactivities. Various organic reactions using azides have been synthetically applied in chemical biology pharmaceuticals medicinal and agricultural areas. In this review we present some recent applications and developments of organic azides in the total synthesis of natural products (mostly within five years) especially alkaloids. We focus not only on application examples of organic azides but also show their preparation methods including recently reported procedures concerning their decomposing and reducing methods in the syntheses of bioactive molecules.

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