ChemInform Abstract: Highly Enantioselective Michael Addition of α-Substituted Cyano Ketones to β,γ-Unsaturated α-Keto Esters Using Bifunctional Thiourea-Tertiary Amine Catalysts: An Easy Access to Chiral Dihydropyrans.

ChemInform ◽  
2010 ◽  
Vol 41 (14) ◽  
Author(s):  
Sheng-Li Zhao ◽  
Chang-Wu Zheng ◽  
Hai-Feng Wang ◽  
Gang Zhao
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Easy Access ◽  
Keto Esters ◽  
Amine Catalysts

scholarly journals A solvent-dependent chirality-switchable thia-Michael addition to α,β-unsaturated carboxylic acids using a chiral multifunctional thiourea catalyst

2020 ◽  
Vol 11 (21) ◽  
pp. 5572-5576 ◽  
Author(s):  
Noboru Hayama ◽  
Yusuke Kobayashi ◽  
Eriko Sekimoto ◽  
Anna Miyazaki ◽  
Kiyofumi Inamoto ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Tertiary Amine ◽  
Michael Addition ◽  
Arylboronic Acid ◽  
Unsaturated Carboxylic Acids

An asymmetric thia-Michael addition of arylthiols to α,β-unsaturated carboxylic acids using a thiourea catalyst that bears arylboronic acid and tertiary amine moieties is reported.

Sugar Based γ-Amino Alcohol Organocatalyst for Asymmetric Michael Addition of β-Keto Esters with Nitroolefins

Heterocycles ◽  
2019 ◽  
Vol 98 (11) ◽  
pp. 1536 ◽  
Author(s):  
Hiroto Nakano ◽  
Divakar Ganesan ◽  
Madhu Chennapuram ◽  
Zubeda Begum ◽  
Chigusa Seki ◽  
...  
Keyword(s):  
Michael Addition ◽  
Amino Alcohol ◽  
Keto Esters ◽  
Asymmetric Michael Addition

scholarly journals Amino Amide Organocatalysts for Asymmetric Michael Addition of β-Keto Esters with β-Nitroolefins

2019 ◽  
Vol 92 (3) ◽  
pp. 696-701 ◽  
Author(s):  
Isiaka Alade Owolabi ◽  
Madhu Chennapuram ◽  
Chigusa Seki ◽  
Yuko Okuyama ◽  
Eunsang Kwon ◽  
...  
Keyword(s):  
Michael Addition ◽  
Keto Esters ◽  
Asymmetric Michael Addition ◽  
Amino Amide

Theoretical studies on the activation mechanism involving bifunctional tertiary amine–thioureas and isatylidene malononitriles

RSC Advances ◽  
2015 ◽  
Vol 5 (43) ◽  
pp. 34314-34318 ◽  
Author(s):  
Zheng-Hang Qi ◽  
Ye Zhang ◽  
Gui-Yu Ruan ◽  
Yi Zhang ◽  
Yong Wang ◽  
...  
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Activation Mechanism ◽  
Addition Reactions ◽  
Theoretical Studies ◽  
Dft Studies ◽  
The Michael Addition

DFT studies on the activation mechanism of the Michael addition reactions containing bifunctional tertiary amine–thioureas and isatylidene malononitriles have been performed at the B3LYP/6-311++G(d,p)//B3LYP/6-31G(d) level of theory.

An Efficient and Scalable One-Pot Double Michael Addition-Dieckmann Condensation for the Synthesis of 4,4-Disubstituted Cyclohexane β-Keto Esters

2007 ◽  
Vol 72 (19) ◽  
pp. 7455-7458 ◽  
Author(s):  
Michael R. DeGraffenreid ◽  
Sarah Bennett ◽  
Sebastien Caille ◽  
Felix Gonzalez-Lopez de Turiso ◽  
Randall W. Hungate ◽  
...  
Keyword(s):  
Michael Addition ◽  
One Pot ◽  
Keto Esters ◽  
Dieckmann Condensation

Asymmetric Michael addition between kojic acid derivatives and unsaturated ketoesters promoted by C2-symmetric organocatalysts

2018 ◽  
Vol 16 (48) ◽  
pp. 9314-9318 ◽  
Author(s):  
Alexey A. Kostenko ◽  
Alexander S. Kucherenko ◽  
Andrey N. Komogortsev ◽  
Boris V. Lichitsky ◽  
Sergei G. Zlotin
Keyword(s):  
Tertiary Amine ◽  
Michael Addition ◽  
Kojic Acid ◽  
Domino Reaction ◽  
Asymmetric Michael Addition

An efficient C2-symmetric bifunctional tertiary amine–squaramide organocatalyst for the asymmetric Michael addition/hemiketalization domino reaction of kojic acid derivatives with β,γ-unsaturated α-ketoesters has been designed.

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