ChemInform Abstract: Water-Soluble Polyelectrolyte Complexes of Oppositely Charged Polysaccharides

ChemInform ◽  
2010 ◽  
Vol 41 (13) ◽  
Author(s):  
Yury A. Shchipunov ◽  
Irina V. Postnova
Keyword(s):  
Water Soluble ◽  
Polyelectrolyte Complexes ◽  
Oppositely Charged

Water-Soluble Polyelectrolyte Complexes of Oppositely Charged Polysaccharides

2009 ◽  
Vol 16 (4-6) ◽  
pp. 251-279 ◽  
Author(s):  
Yury A. Shchipunov ◽  
Irina V. Postnova
Keyword(s):  
Water Soluble ◽  
Polyelectrolyte Complexes ◽  
Oppositely Charged

scholarly journals Solubilization of Charged Porphyrins in Interpolyelectrolyte Complexes: A Computer Study

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 502
Author(s):  
Karel Šindelka ◽  
Zuzana Limpouchová ◽  
Karel Procházka
Keyword(s):  
Dissipative Particle Dynamics ◽  
Water Soluble ◽  
Coarse Grained ◽  
Core Shell ◽  
Computer Study ◽  
Interpolyelectrolyte Complex ◽  
The Core ◽  
Porphyrin Derivatives ◽  
Oppositely Charged ◽  
Positively Charged

Using coarse-grained dissipative particle dynamics (DPD) with explicit electrostatics, we performed (i) an extensive series of simulations of the electrostatic co-assembly of asymmetric oppositely charged copolymers composed of one (either positively or negatively charged) polyelectrolyte (PE) block A and one water-soluble block B and (ii) studied the solubilization of positively charged porphyrin derivatives (P+) in the interpolyelectrolyte complex (IPEC) cores of co-assembled nanoparticles. We studied the stoichiometric mixtures of 137 A10+B25 and 137 A10−B25 chains with moderately hydrophobic A blocks (DPD interaction parameter aAS=35) and hydrophilic B blocks (aBS=25) with 10 to 120 P+ added (aPS=39). The P+ interactions with other components were set to match literature information on their limited solubility and aggregation behavior. The study shows that the moderately soluble P+ molecules easily solubilize in IPEC cores, where they partly replace PE+ and electrostatically crosslink PE− blocks. As the large P+ rings are apt to aggregate, P+ molecules aggregate in IPEC cores. The aggregation, which starts at very low loadings, is promoted by increasing the number of P+ in the mixture. The positively charged copolymers repelled from the central part of IPEC core partially concentrate at the core-shell interface and partially escape into bulk solvent depending on the amount of P+ in the mixture and on their association number, AS. If AS is lower than the ensemble average ⟨AS⟩n, the copolymer chains released from IPEC preferentially concentrate at the core-shell interface, thus increasing AS, which approaches ⟨AS⟩n. If AS>⟨AS⟩n, they escape into the bulk solvent.

Non-stoichiometric polyelectrolyte complexes: New, water soluble macromolecular compounds

1979 ◽  
Vol 21 (12) ◽  
pp. 3002-3008 ◽  
Author(s):  
O.A. Kharenko ◽  
A.V. Kharenko ◽  
R.I. Kalyuzhnaya ◽  
V.A. Izumrudov ◽  
V.A. Kasaikin ◽  
...  
Keyword(s):  
Water Soluble ◽  
Polyelectrolyte Complexes

scholarly journals Influence of the SolubleInsoluble Ratios of Cyclodextrins Polymers on the Viscoelastic Properties of Injectable ChitosanBased Hydrogels for Biomedical Application

Polymers ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 214 ◽  
Author(s):  
Carla Palomino-Durand ◽  
Marco Lopez ◽  
Frédéric Cazaux ◽  
Bernard Martel ◽  
Nicolas Blanchemain ◽  
...  
Keyword(s):  
Viscoelastic Properties ◽  
Biomedical Applications ◽  
Structural Integrity ◽  
Biomedical Application ◽  
Water Soluble ◽  
Self Healing ◽  
Indirect Contact ◽  
Polyelectrolyte Complexes ◽  
Anionic Polymers ◽  
The Difference

Injectable pre-formed physical hydrogels provide many advantages for biomedical applications. Polyelectrolyte complexes (PEC) formed between cationic chitosan (CHT) and anionic polymers of cyclodextrin (PCD) render a hydrogel of great interest. Given the difference between water-soluble (PCDs) and water-insoluble PCD (PCDi) in the extension of polymerization, the present study aims to explore their impact on the formation and properties of CHT/PCD hydrogel obtained from the variable ratios of PCDi and PCDs in the formulation. Hydrogels CHT/PCDi/PCDs at weight ratios of 3:0:3, 3:1.5:1.5, and 3:3:0 were elaborated in a double–syringe system. The chemical composition, microstructure, viscoelastic properties, injectability, and structural integrity of the hydrogels were investigated. The cytotoxicity of the hydrogel was also evaluated by indirect contact with pre-osteoblast cells. Despite having similar shear–thinning and self-healing behaviors, the three hydrogels showed a marked difference in their rheological characteristics, injectability, structural stability, etc., depending on their PCDi and PCDs contents. Among the three, all the best above-mentioned properties, in addition to a high cytocompatibility, were found in the hydrogel 3:1.5:1.5. For the first time, we gained a deeper understanding of the role of the PCDi/PCDs in the injectable pre-formed hydrogels (CHT/PCDi/PCDs), which could be further fine-tuned to enhance their performance in biomedical applications.

scholarly journals Nanostructured Polyelectrolyte Complexes Based on Water-Soluble Thiacalix[4]Arene and Pillar[5]Arene: Self-Assembly in Micelleplexes and Polyplexes at Packaging DNA

Nanomaterials ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. 777 ◽  
Author(s):  
Luidmila S. Yakimova ◽  
Aigul R. Nugmanova ◽  
Olga A. Mostovaya ◽  
Alena A. Vavilova ◽  
Dmitriy N. Shurpik ◽  
...  
Keyword(s):  
Self Assembly ◽  
Water Soluble ◽  
Macrocyclic Compounds ◽  
Polyelectrolyte Complexes ◽  
Calf Thymus ◽  
Polyfunctional Compounds ◽  
Mixed Nanoparticles ◽  
The One ◽  
New Generation ◽  
Straightforward Approach

Controlling the self-assembly of polyfunctional compounds in interpolyelectrolyte aggregates is an extremely challenging task. The use of macrocyclic compounds offers new opportunities in design of a new generation of mixed nanoparticles. This approach allows creating aggregates with multivalent molecular recognition, improved binding efficiency and selectivity. In this paper, we reported a straightforward approach to the synthesis of interpolyelectrolytes by co-assembling of the thiacalix[4]arene with four negatively charged functional groups on the one side of macrocycle, and pillar[5]arene with 10 ammonium groups located on both sides. Nanostructured polyelectrolyte complexes show effective packaging of high-molecular DNA from calf thymus. The interaction of co-interpolyelectrolytes with the DNA is completely different from the interaction of the pillar[5]arene with the DNA. Two different complexes with DNA, i.e., micelleplex- and polyplex-type, were formed. The DNA in both cases preserved its secondary structure in native B form without distorting helicity. The presented approach provides important advantage for the design of effective biomolecular gene delivery systems.

Formation and Stability of Water-Soluble, Molecular Polyelectrolyte Complexes: Effects of Charge Density, Mixing Ratio, and Polyelectrolyte Concentration

Langmuir ◽  
2009 ◽  
Vol 25 (11) ◽  
pp. 6113-6121 ◽  
Author(s):  
Alexander Shovsky ◽  
Imre Varga ◽  
Ričardas Makuška ◽  
Per M. Claesson
Keyword(s):  
Charge Density ◽  
Water Soluble ◽  
Mixing Ratio ◽  
Polyelectrolyte Complexes ◽  
Stability Of Water

Exciton Transfer and Emergent Excitonic States in Oppositely-Charged Conjugated Polyelectrolyte Complexes

2016 ◽  
Vol 120 (31) ◽  
pp. 7767-7774 ◽  
Author(s):  
William R. Hollingsworth ◽  
Carmen Segura ◽  
Jonathan Balderrama ◽  
Nathaniel Lopez ◽  
Pamela Schleissner ◽  
...  
Keyword(s):  
Polyelectrolyte Complexes ◽  
Conjugated Polyelectrolyte ◽  
Exciton Transfer ◽  
Excitonic States ◽  
Oppositely Charged

Water soluble chitosan conjugates with plant antioxidants and polyelectrolyte complexes on their basis

2006 ◽  
Vol 16 (4) ◽  
pp. 279-283 ◽  
Author(s):  
V.A. Alexandrova ◽  
N.G. Balabushevich ◽  
G.N. Bondarenko ◽  
N.S. Domnina ◽  
N.I. Larionova
Keyword(s):  
Water Soluble ◽  
Polyelectrolyte Complexes ◽  
Plant Antioxidants
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