ChemInform Abstract: PdII-Catalyzed Asymmetric Addition Reactions of 1,3-Dicarbonyl Compounds: Mannich-Type Reactions with N-Boc Imines and Three-Component Aminomethylation.

ChemInform ◽  
2009 ◽  
Vol 40 (1) ◽  
Author(s):  
Yoshitaka Hamashima ◽  
Naoki Sasamoto ◽  
Natsuko Umebayashi ◽  
Mikiko Sodeoka
Keyword(s):  
Addition Reactions ◽  
Asymmetric Addition ◽  
Dicarbonyl Compounds

A Strategy for Synthesizing Axially Chiral Naphthyl‐Indoles: Catalytic Asymmetric Addition Reactions of Racemic Substrates

2019 ◽  
Vol 131 (42) ◽  
pp. 15248-15254 ◽  
Author(s):  
Fei Jiang ◽  
Ke‐Wei Chen ◽  
Ping Wu ◽  
Yu‐Chen Zhang ◽  
Yinchun Jiao ◽  
...  
Keyword(s):  
Addition Reactions ◽  
Asymmetric Addition ◽  
Axially Chiral ◽  
Catalytic Asymmetric

Asymmetric Addition Reactions of Grignard Reagents to Chiral 2-Trifluoromethyl tert-Butyl (Ellman) Sulfinimine—Ethanol Adducts.

ChemInform ◽  
2006 ◽  
Vol 37 (29) ◽  
Author(s):  
Scott D. Kuduk ◽  
Christina Ng Di Marco ◽  
Steven M. Pitzenberger ◽  
Nancy Tsou
Keyword(s):  
Grignard Reagents ◽  
Addition Reactions ◽  
Asymmetric Addition ◽  
Tert Butyl

Asymmetric Conjugate Addition of α-Cyanoketones to Benzoyl Acrylonitrile Derivatives Using a Diaminomethylenemalononitrile Organocatalyst

Synthesis ◽  
2020 ◽  
Vol 52 (24) ◽  
pp. 3874-3880 ◽  
Author(s):  
Tsuyoshi Miura ◽  
Hiroshi Akutsu ◽  
Kosuke Nakashima ◽  
Yuta Kanetsuna ◽  
Masahiro Kawada ◽  
...  
Keyword(s):  
Catalytic Activity ◽  
Conjugate Addition ◽  
Significant Loss ◽  
Addition Reactions ◽  
Dicarbonyl Compounds ◽  
Stereogenic Centers ◽  
Synthetic Intermediates ◽  
Quaternary Stereogenic Centers

AbstractA diaminomethylenemalononitrile (DMM) organocatalyst was used to efficiently promote asymmetric conjugate addition of various α-cyanoketones to benzoyl acrylonitrile derivatives. The corresponding 1,5-dicarbonyl compounds containing vicinal tertiary and quaternary stereogenic centers are versatile synthetic intermediates and were obtained in good yields and with excellent enantioselectivities (up to 96% ee). The present study describes the first successful examples of asymmetric conjugate addition reactions of α-cyanoketones with benzoyl acrylonitriles. In addition, the DMM organocatalyst can be recovered and reused up to five times without significant loss of either catalytic activity or enantioselectivity.

Core-structure-inspired asymmetric addition reactions: enantioselective synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents

2015 ◽  
Vol 44 (21) ◽  
pp. 7439-7448 ◽  
Author(s):  
Shen Li ◽  
Jun-An Ma
Keyword(s):  
Asymmetric Synthesis ◽  
Core Structure ◽  
Enantioselective Synthesis ◽  
Addition Reactions ◽  
Asymmetric Addition ◽  
Anti Hiv Agents ◽  
Anti Hiv

An overview of the asymmetric synthesis of dihydrobenzoxazinone- and dihydroquinazolinone-based anti-HIV agents (Efavirenz, DPC 961, DPC 963, DPC 083) and analogues was presented.

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