ChemInform Abstract: Recent Progress in the Improvement of the Coupling Efficiency of “Difficult Sequences” in Peptide Synthesis

ChemInform ◽  
2008 ◽  
Vol 39 (44) ◽  
Author(s):  
Xiang Han ◽  
Dexin Wang
Keyword(s):  
Peptide Synthesis ◽  
Recent Progress ◽  
Coupling Efficiency ◽  
Difficult Sequences

ChemInform Abstract: Recent Progress in the Chemoenzymatic Peptide Synthesis

ChemInform ◽  
2011 ◽  
Vol 42 (34) ◽  
pp. no-no
Author(s):  
Feifei Chen ◽  
Fangkai Zhang ◽  
Anming Wang ◽  
Haifeng Li ◽  
Qiuyan Wang ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Recent Progress

ChemInform Abstract: Convergent Solid Phase Peptide Synthesis: Recent Progress

ChemInform ◽  
1988 ◽  
Vol 19 (3) ◽  
Author(s):  
J. VAN RIETSCHOTEN ◽  
J. M. SABATIER ◽  
M. TESSIER ◽  
C. GRANIER ◽  
E. PEDROSO ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Recent Progress ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis

scholarly journals Progress in direct-drive fusion studies for the Laser Mégajoule

2004 ◽  
Vol 22 (2) ◽  
pp. 109-114 ◽  
Author(s):  
B. CANAUD ◽  
X. FORTIN ◽  
F. GARAUDE ◽  
C. MEYER ◽  
F. PHILIPPE
Keyword(s):  
Recent Progress ◽  
Coupling Efficiency ◽  
Direct Drive ◽  
Time Analysis ◽  
Laser Target ◽  
Long Wavelength ◽  
Laser Driver ◽  
Indirect Drive ◽  
Ice Shell ◽  
Target Design

In the context of the French Laser Mégajoule (LMJ) fusion research program, direct drive is an alternate to indirect drive to reach ignition and thermonuclear burn. We present recent progress in the direct-drive fusion studies for LMJ. Calculations have shown that the LMJ irradiation uniformity is characterized by long wavelength asymmetries compatible with direct drive requirements. Calculations of the irradiation uniformity in the context of indirect drive beam positioning have been done. We show that non-uniformity can be minimized by repointing the beams. Unfortunately, a time analysis shows that this nonuniformity increases strongly in time above levels usually considered inconsistent for direct drive. Finally, a recent baseline target design is presented and consists of a DT ice shell surrounded by a low-density CH foam wicked with cryogenic DT. This design can potentially reach a gain of 90 with a 1-MJ on-target laser driver. Hydrodynamic stability is increased at the ablation front and the laser–target coupling efficiency achieves 85%.

Aqueous Microwave-Assisted Solid-Phase Peptide Synthesis Using Fmoc Strategy: In-Water Synthesis of "Difficult Sequences"

2012 ◽  
Vol 19 (11) ◽  
pp. 1231-1236 ◽  
Author(s):  
Keiko Hojo ◽  
Hideki Ichikawa ◽  
Asaki Hara ◽  
Mare Onishi ◽  
Koichi Kawasaki ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Solid Phase ◽  
Solid Phase Peptide Synthesis ◽  
Microwave Assisted ◽  
Difficult Sequences ◽  
Fmoc Strategy

Rapid Access to ω-Conotoxin Chimeras using Native Chemical Ligation

2009 ◽  
Vol 62 (10) ◽  
pp. 1333 ◽  
Author(s):  
Gene Hopping ◽  
Richard J. Lewis ◽  
Paul F. Alewood
Keyword(s):  
Ligand Binding ◽  
Coupling Efficiency ◽  
Native Chemical Ligation ◽  
Binding Assays ◽  
Chemical Ligation ◽  
Receptor Recognition ◽  
Single Protein ◽  
Difficult Sequences ◽  
Peptide Segments ◽  
Ligation Method

Grafting different regions of related peptides together to form a single protein chimera is a valuable tool in rapidly elucidating regions of activity or selectivity in peptides and proteins. To conveniently evaluate the contributions of the N- and C-terminal segments of ω-conotoxins CVID and MVIIC to activity, we employed native chemical ligation in CVID-MVIIC chimera design. Assembly of these peptide segments via the ligation method improved overall yield and coupling efficiency, with no difficult sequences encountered in contrast to the traditional full-length chain assembly of CVID. Radio-ligand binding assays revealed regions of importance for receptor recognition.

Assessment of new 6-Cl-HOBt based coupling reagents for peptide synthesis. Part 1: Coupling efficiency study

2002 ◽  
Vol 9 (2-3) ◽  
pp. 119-123 ◽  
Author(s):  
Giuseppina Sabatino ◽  
Barbara Mulinacci ◽  
Maria C. Alcaro ◽  
Mario Chelli ◽  
Paolo Rovero ◽  
...  
Keyword(s):  
Peptide Synthesis ◽  
Coupling Efficiency ◽  
Coupling Reagents
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