ChemInform Abstract: Total Syntheses and Synthetic Studies of Spongiane Diterpenes

ChemInform ◽  
2008 ◽  
Vol 39 (22) ◽  
Author(s):  
Miguel A. Gonzalez
Keyword(s):  
Total Syntheses ◽  
Synthetic Studies

ChemInform Abstract: Synthetic Studies on Indoles and Related Compounds. Part 46. First Total Syntheses of 4,8-Dioxygenated β-Carboline Alkaloids (I).

ChemInform ◽  
2010 ◽  
Vol 30 (44) ◽  
pp. no-no
Author(s):  
Hideharu Suzuki ◽  
Minoru Unemoto ◽  
Mayumi Hagiwara ◽  
Takako Ohyama ◽  
Yuusaku Yokoyama ◽  
...  
Keyword(s):  
Total Syntheses ◽  
Synthetic Studies ◽  
Related Compounds

Biomimetic synthetic studies on meroterpenoids from the marine sponge Aka coralliphaga: Divergent total syntheses of siphonodictyal B, liphagal and corallidictyals A–D

2019 ◽  
Vol 27 (12) ◽  
pp. 2449-2465 ◽  
Author(s):  
Kevin K.W. Kuan ◽  
Adrian W. Markwell-Heys ◽  
Michelle C. Cruickshank ◽  
Denise P. Tran ◽  
Robert M. Adlington ◽  
...  
Keyword(s):  
Marine Sponge ◽  
Total Syntheses ◽  
Synthetic Studies

scholarly journals The Calyciphylline B-type Alkaloids: Total Syntheses of (–)-Daphlongamine H and (–)-Isodaphlongamine H

2019 ◽  
Author(s):  
Cedric Hugelshofer ◽  
Vignesh Palani ◽  
Richmond Sarpong
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Mannich Reaction ◽  
Biosynthetic Pathway ◽  
Total Syntheses ◽  
Diastereoselective Hydrogenation ◽  
Tricyclic Core ◽  
Synthetic Studies

The first total synthesis of the complex hexacylic Daphniphyllum alkaloid (–)-daphlongamine H in enantioenriched form has been accomplished. Key to the success of the strategy are a complexity-building Mannich reaction, efficient cyclizations, and a highly diastereoselective hydrogenation to assemble multigram quantities of the tricyclic core bearing four contiguous stereocenters. Following construction of the hydro-indene substructure by means of a Pauson–Khand reaction, endgame redox manipulations delivered the natural product. Importantly, the synthetic studies have also given access to (–)-isodaphlongamine H and led to a revision of the reported structure of deoxyisocalyciphylline B, which resulted in the proposal of a modified biosynthetic pathway to the calyciphylline B-type alkaloids.

ChemInform Abstract: SYNTHETIC STUDIES TOWARD MITOMYCINS. III. TOTAL SYNTHESES OF MITOMYCINS A AND D C

1978 ◽  
Vol 9 (7) ◽  
Author(s):  
T. FUKUYAMA ◽  
F. NAKATSUBO ◽  
A. J. COCUZZA ◽  
Y. KISHI
Keyword(s):  
Total Syntheses ◽  
Synthetic Studies

Synthetic studies on glycosphingolipids from Protostomia phyla: total syntheses of glycosphingolipids from the parasite, Echinococcus multilocularis

2004 ◽  
Vol 339 (17) ◽  
pp. 2749-2759 ◽  
Author(s):  
Takeshi Yamamura ◽  
Noriyasu Hada ◽  
Asuka Kaburaki ◽  
Kimiaki Yamano ◽  
Tadahiro Takeda
Keyword(s):  
Echinococcus Multilocularis ◽  
Total Syntheses ◽  
Synthetic Studies

scholarly journals The Calyciphylline B-type Alkaloids: Total Syntheses of (–)-Daphlongamine H and (–)-Isodaphlongamine H

2019 ◽  
Author(s):  
Cedric Hugelshofer ◽  
Vignesh Palani ◽  
Richmond Sarpong
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Mannich Reaction ◽  
Biosynthetic Pathway ◽  
Total Syntheses ◽  
Diastereoselective Hydrogenation ◽  
Tricyclic Core ◽  
Synthetic Studies

The first total synthesis of the complex hexacylic Daphniphyllum alkaloid (–)-daphlongamine H in enantioenriched form has been accomplished. Key to the success of the strategy are a complexity-building Mannich reaction, efficient cyclizations, and a highly diastereoselective hydrogenation to assemble multigram quantities of the tricyclic core bearing four contiguous stereocenters. Following construction of the hydro-indene substructure by means of a Pauson–Khand reaction, endgame redox manipulations delivered the natural product. Importantly, the synthetic studies have also given access to (–)-isodaphlongamine H and led to a revision of the reported structure of deoxyisocalyciphylline B, which resulted in the proposal of a modified biosynthetic pathway to the calyciphylline B-type alkaloids.

scholarly journals Recent Chemical Methodology Advances in the Total Synthesis of Meroterpenoids

2021 ◽  
Vol 68 (2) ◽  
pp. 247-267
Author(s):  
Jan Petrovčič ◽  
Chad Nicholas Ungarean ◽  
David Sarlah
Keyword(s):  
Organic Chemistry ◽  
Natural Products ◽  
Total Synthesis ◽  
Feature Article ◽  
Total Syntheses ◽  
Synthetic Organic Chemistry ◽  
Synthetic Studies

Heterogeneity of meroterpenoids arising from their dual biosynthetic origins is constantly provoking synthetic chemists to utilize their ingenuity and revise their retrosynthetic logic. By studying recent publications on meroterpenoid synthesis,tremendous advances in the field of synthetic organic chemistry can be witnessed. This feature article covers some of the most intriguing total syntheses and synthetic studies towards the meroterpenoid class of natural products from the last five years.

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