Synthesis of New Chiral 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazines from α-Amino Acid Derivatives under Mild Conditions.

ChemInform ◽  
2007 ◽  
Vol 38 (48) ◽  
Author(s):  
Debendra K. Mohapatra ◽  
Pradip K. Maity ◽  
Rajesh G. Gonnade ◽  
Mukund S. Chorghade ◽  
Mukund K. Gurjar
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Mild Conditions

Enantioselective oxidative functionalization of the Csp3–H bond adjacent to a nitrogen atom for rapid access to β-hydroxyl-α-amino acid derivatives

2016 ◽  
Vol 52 (79) ◽  
pp. 11831-11833 ◽  
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Yu Qian ◽  
Changcheng Jing ◽  
Chaoqun Ma ◽  
...  
Keyword(s):  
Amino Acid ◽  
Nitrogen Atom ◽  
Amino Acid Derivatives ◽  
One Pot ◽  
Oxidative Functionalization ◽  
Mild Conditions ◽  
Rapid Access

Highly chemoselective and enantioselective one-pot reactions involved in the oxidative functionalization of Csp3–H bonds adjacent to nitrogen atoms were developed to rapidly construct highly functionalized β-hydroxyl-α-amino acid derivatives from simple starting materials under mild conditions.

Synthesis of New Chiral 4,5,6,7-Tetrahydro[1,2,3]triazolo[1,5-a]pyrazines from α-Amino Acid Derivatives under Mild Conditions

Synlett ◽  
2007 ◽  
Vol 2007 (12) ◽  
pp. 1893-1896 ◽  
Author(s):  
Debendra Mohapatra ◽  
Pradip Maity ◽  
Rajesh Gonnade ◽  
Mukund Chorghade ◽  
Mukund Gurjar
Keyword(s):  
Amino Acid ◽  
Amino Acid Derivatives ◽  
Mild Conditions

Three Amino Acid Derivatives of Valproic Acid: Design, Synthesis, Theoretical and Experimental Evaluation as Anticancer Agents

2014 ◽  
Vol 14 (7) ◽  
pp. 984-993 ◽  
Author(s):  
Gabriela Luna-Palencia ◽  
Federico Martinez-Ramos ◽  
Ismael Vasquez-Moctezuma ◽  
Manuel Fragoso-Vazquez ◽  
Jessica Mendieta-Wejebe ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Amino Acid ◽  
Anticancer Agents ◽  
Experimental Evaluation ◽  
Amino Acid Derivatives ◽  
Design Synthesis ◽  
Derivatives Of

scholarly journals In vitro anticancer potentiality and molecular modelling study of novel amino acid derivatives based on N1,N3-bis-(1-hydrazinyl-1-oxopropan-2-yl) isophthalamide

2019 ◽  
Vol 34 (1) ◽  
pp. 1247-1258 ◽  
Author(s):  
Asmaa F. Kassem ◽  
Gaber O. Moustafa ◽  
Eman S. Nossier ◽  
Hemat S. Khalaf ◽  
Marwa M. Mounier ◽  
...  
Keyword(s):  
Amino Acid ◽  
Molecular Modelling ◽  
Amino Acid Derivatives ◽  
Modelling Study

scholarly journals Synthesis and antimicrobial activity of some novel 1,2-dihydro-[1,2,4]triazolo[1,5-a]pyrimidines bearing amino acid moiety

RSC Advances ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 2905-2916
Author(s):  
Mounir A. A. Mohamed ◽  
Adnan A. Bekhit ◽  
Omyma A. Abd Allah ◽  
Asmaa M. Kadry ◽  
Tamer M. Ibrahim ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Amino Acid ◽  
Green Chemistry ◽  
Antimicrobial Activities ◽  
Amino Acid Derivatives ◽  
Acid Moiety ◽  
Amino Acid Moiety

A new series of [1,2,4]-triazole bearing amino acid derivatives were synthesized under green chemistry conditions and evaluated for their antimicrobial activities.

Enantioselective Nucleophilic Aromatic Substitution Reaction of Azlactones to Synthesize Quaternary α-Amino Acid Derivatives

Synlett ◽  
2020 ◽  
Author(s):  
Xiaohua Liu ◽  
Yi Li ◽  
Hao Pan ◽  
Wang-Yuren Li ◽  
Xiaoming Feng
Keyword(s):  
Hydrogen Bonding ◽  
Charge Transfer ◽  
Amino Acid ◽  
Substitution Reaction ◽  
Nucleophilic Aromatic Substitution ◽  
Amino Acid Derivatives ◽  
Amino Acid Esters ◽  
Aromatic Substitution ◽  
Charge Transfer Interaction ◽  
Acid Esters

AbstractAn asymmetric organocatalytic nucleophilic aromatic substitution reaction of azlactones with electron-deficient aryls was established. A variety of α-aryl α-alkyl α-amino acid esters and peptides were obtained in decent yields and stereoselectivities. A new bifunctional catalytic mode involving charge-transfer interaction and hydrogen bonding is proposed to explain the enantioselectivity.

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