scholarly journals The Use of Aryl Hydrazide Linkers for the Solid-Phase Synthesis of Chemically Modified Peptides

ChemInform ◽  
2007 ◽  
Vol 38 (47) ◽  
Author(s):  
Youn-Hi Woo ◽  
Alexander R. Mitchell ◽  
Julio A. Camarero
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Chemically Modified ◽  
Modified Peptides

Backbone Amide Linker Strategies for the Solid-Phase Synthesis of C-Terminal Modified Peptides

ChemInform ◽  
2006 ◽  
Vol 37 (9) ◽  
Author(s):  
Jordi Alsina ◽  
Steven A. Kates ◽  
George Barany ◽  
Fernando Albericio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Backbone Amide ◽  
Modified Peptides ◽  
Backbone Amide Linker

Solid-phase synthesis ofC-terminally modified peptides

2006 ◽  
Vol 12 (11) ◽  
pp. 686-692 ◽  
Author(s):  
Hefziba T. Ten Brink ◽  
Joris T. Meijer ◽  
Remon V. Geel ◽  
Mark Damen ◽  
Dennis W. P. M. Löwik ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Modified Peptides

Solid-phase synthesis of C-terminal modified peptides

Biopolymers ◽  
2003 ◽  
Vol 71 (4) ◽  
pp. 454-477 ◽  
Author(s):  
Jordi Alsina ◽  
Fernando Albericio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Modified Peptides

Convenient Solid-Phase Synthesis of Ureido-Pyrimidinone Modified Peptides

2007 ◽  
Vol 2007 (22) ◽  
pp. 3622-3632 ◽  
Author(s):  
Patricia Y. W. Dankers ◽  
P. J. H. M. Adams ◽  
Dennis W. P. M. Löwik ◽  
Jan C. M. van Hest ◽  
E. W. Meijer
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Modified Peptides

Solid-Phase Synthesis of C-Terminal Modified Peptides

ChemInform ◽  
2004 ◽  
Vol 35 (15) ◽  
Author(s):  
Jordi Alsina ◽  
Fernando Albericio
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Modified Peptides

scholarly journals Beyond ribose and phosphate: Selected nucleic acid modifications for structure–function investigations and therapeutic applications

2021 ◽  
Vol 17 ◽  
pp. 908-931
Author(s):  
Christopher Liczner ◽  
Kieran Duke ◽  
Gabrielle Juneau ◽  
Martin Egli ◽  
Christopher J Wilds
Keyword(s):  
Gene Silencing ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Modified Nucleosides ◽  
New Drugs ◽  
Biophysical Properties ◽  
Phase Synthesis ◽  
Chemically Modified ◽  
The Past ◽  
Cellular Machinery

Over the past 25 years, the acceleration of achievements in the development of oligonucleotide-based therapeutics has resulted in numerous new drugs making it to the market for the treatment of various diseases. Oligonucleotides with alterations to their scaffold, prepared with modified nucleosides and solid-phase synthesis, have yielded molecules with interesting biophysical properties that bind to their targets and are tolerated by the cellular machinery to elicit a therapeutic outcome. Structural techniques, such as crystallography, have provided insights to rationalize numerous properties including binding affinity, nuclease stability, and trends observed in the gene silencing. In this review, we discuss the chemistry, biophysical, and structural properties of a number of chemically modified oligonucleotides that have been explored for gene silencing.

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