An Efficient Route for the Synthesis of a New Class of Pyrido[2,3-d]pyrimidine Derivatives.

ChemInform ◽  
2007 ◽  
Vol 38 (38) ◽  
Author(s):  
Shujiang Tu ◽  
Junyong Zhang ◽  
Runhong Jia ◽  
Bo Jiang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
New Class ◽  
Efficient Route

An efficient route for the synthesis of a new class of pyrido[2,3-d]pyrimidine derivatives

2007 ◽  
Vol 5 (9) ◽  
pp. 1450 ◽  
Author(s):  
Shujiang Tu ◽  
Junyong Zhang ◽  
Runhong Jia ◽  
Bo Jiang ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Pyrimidine Derivatives ◽  
New Class ◽  
Efficient Route

scholarly journals Enamine Barbiturates and Thiobarbiturates as a New Class of Bacterial Urease Inhibitors

2020 ◽  
Vol 10 (10) ◽  
pp. 3523
Author(s):  
M. Ali ◽  
Assem Barakat ◽  
Ayman El-Faham ◽  
Abdullah Mohammed Al-Majid ◽  
Sammer Yousuf ◽  
...  
Keyword(s):  
Density Functional ◽  
Dft Method ◽  
Docking Study ◽  
Acetohydroxamic Acid ◽  
Urease Inhibitors ◽  
Pyrimidine Derivatives ◽  
Functional Theory ◽  
New Class ◽  
The Density Functional Theory ◽  
Privileged Structure

Urease is a therapeutic target associated with several important diseases and health problems. Based on our previous work on the inhibition of glucosidase and other enzymes and exploiting the privileged structure assigned to the (thio)barbiturate (pyrimidine) scaffold, here we tested the capacity of two (thio)barbiturate-based compound collections to inhibit urease. Several compounds showed more activity than acetohydroxamic acid as a standard tested compound. In addition, by means of a conformational study and using the Density Functional Theory (DFT) method, we identified energetically low-lying conformers. Finally, we undertook a docking study to explore the binding mechanism of these new pyrimidine derivatives as urease inhibitors.

ChemInform Abstract: 1,2,3-Triazolo(5,4-e)1,2,4-triazolo(1,5-c)pyrimidine Derivatives: A New Class of A2A Adenosine Receptor Antagonists.

ChemInform ◽  
2010 ◽  
Vol 27 (37) ◽  
pp. no-no
Author(s):  
P. G. BARALDI ◽  
B. CACCIARI ◽  
G. SPALLUTO ◽  
M. J. PINEDA DE LAS INFANTS ◽  
C. ZOCCHI ◽  
...  
Keyword(s):  
Adenosine Receptor ◽  
Pyrimidine Derivatives ◽  
Receptor Antagonists ◽  
A2a Adenosine Receptor ◽  
New Class
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