scholarly journals Asymmetric Hydrogenation of Enol Phosphinates by Iridium Catalysts Having N,P Ligands.

ChemInform ◽  
2007 ◽  
Vol 38 (36) ◽  
Author(s):  
Pradeep Cheruku ◽  
Suresh Gohil ◽  
Pher G. Andersson
Keyword(s):  
Asymmetric Hydrogenation ◽  
Iridium Catalysts ◽  
P Ligands

Asymmetric Hydrogenation of Enol Phosphinates by Iridium Catalysts Having N,P Ligands

2007 ◽  
Vol 9 (9) ◽  
pp. 1659-1661 ◽  
Author(s):  
Pradeep Cheruku ◽  
Suresh Gohil ◽  
Pher G. Andersson
Keyword(s):  
Asymmetric Hydrogenation ◽  
Iridium Catalysts ◽  
P Ligands

ChemInform Abstract: Chiral Iridium Catalysts Bearing Spiro Pyridine-Aminophosphine Ligands Enable Highly Efficient Asymmetric Hydrogenation of β-Aryl β-Ketoesters.

ChemInform ◽  
2012 ◽  
Vol 43 (20) ◽  
pp. no-no
Author(s):  
Jian-Hua Xie ◽  
Xiao-Yan Liu ◽  
Xiao-Hui Yang ◽  
Jian-Bo Xie ◽  
Li-Xin Wang ◽  
...  
Keyword(s):  
Asymmetric Hydrogenation ◽  
Iridium Catalysts ◽  
Highly Efficient

ChemInform Abstract: Iridium Catalysts with Chiral Imidazole-Phosphine Ligands for Asymmetric Hydrogenation of Vinyl Fluorides and other Olefins.

ChemInform ◽  
2008 ◽  
Vol 39 (39) ◽  
Author(s):  
Paeivi Kaukoranta ◽  
Mattias Engman ◽  
Christian Hedberg ◽  
Jonas Bergquist ◽  
Pher G. Andersson
Keyword(s):  
Asymmetric Hydrogenation ◽  
Phosphine Ligands ◽  
Iridium Catalysts ◽  
Vinyl Fluorides

Temperature-Controlled Bidirectional Enantioselectivity in Asymmetric Hydrogenation Reactions Utilizing Stereodynamic Iridium Complexes

Synthesis ◽  
2017 ◽  
Vol 49 (15) ◽  
pp. 3485-3494 ◽  
Author(s):  
Max Siebert ◽  
Golo Storch ◽  
Frank Rominger ◽  
Oliver Trapp
Keyword(s):  
Elevated Temperatures ◽  
Asymmetric Hydrogenation ◽  
Iridium Complexes ◽  
Chirality Transfer ◽  
Iridium Catalysts ◽  
Thermal Equilibration ◽  
Hydrogenation Reactions ◽  
Temperature Controlled ◽  
First Time ◽  
Solid State Structures

Stereochemically flexible 2,2(-bis(diphenylphosphino)biphenyl (BIPHEP) ligands were modified with chiral α-substituted carboxylic acid auxiliaries in the 3- and 3′-position. The resulting central-to-axial chirality transfer to the stereochemically flexible chiral axis of the BIPHEP­ core was investigated as well as complexation of these diastereomeric ligands to iridium(I). Solid-state structures of both ligand diastereomers and a diastereomerically pure iridium(I) BIPHEP complex were obtained. Thermal equilibration of the resulting iridium(I) complexes was studied to investigate the stereodynamic properties of the BIPHEP ligands. The iridium(I) complexes without and after pre-catalysis warming in solution — which induces a shift of the diastereomeric ratio — were applied for asymmetric hydrogenation of a prochiral α-substituted acrylic acid, resulting in temperature-controlled bidirectional enantioselectivity of iridium catalysts for the first time. In both cases, enantioenriched (R)-naproxen as well as (S)-naproxen — after re-equilibration of the catalyst at elevated temperatures — was obtained by using the same catalyst.

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