Substitution of Allylic Acetates with Sodium para-Toluenesulfinate in Aqueous Media Using Allylpalladium Chloride Dimer and a Water-Soluble Ligand as the Catalytic System: Electrospray Ionization Mass Spectrometry Analysis.

ChemInform ◽  
2007 ◽  
Vol 38 (20) ◽  
Author(s):  
Carole Chevrin ◽  
Jean Le Bras ◽  
Anna Roglans ◽  
Dominique Harakat ◽  
Jacques Muzart
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Catalytic System ◽  
Electrospray Ionization Mass Spectrometry ◽  
Aqueous Media ◽  
Water Soluble ◽  
Mass Spectrometry Analysis ◽  
Ionization Mass ◽  
Spectrometry Analysis ◽  
Soluble Ligand

Dereplication of Bromotyrosine-derived Metabolites by LC-PDA-MS and Analysis of the Chemical Profile of 14 Aplysina Sponge Specimens from the Brazilian Coastline

2010 ◽  
Vol 63 (6) ◽  
pp. 886 ◽  
Author(s):  
Michelli M. Silva ◽  
Juliana Bergamasco ◽  
Simone P. Lira ◽  
Norberto P. Lopes ◽  
Eduardo Hajdu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Electrospray Ionization Mass Spectrometry ◽  
Marine Sponges ◽  
Mass Spectrometry Analysis ◽  
Ionization Mass ◽  
Chemical Profile ◽  
Spectrometry Analysis ◽  
Ion Clusters ◽  
Single Compound

In order to investigate the chemical profile of 14 specimens of Aplysina spp. marine sponges, we have developed a method based on LC-PDA-MS for the detection of bromotyrosine-derived metabolites. The method enabled the dereplication of three distinct chemotypes of bromotyrosine-derived compounds based on UV absorptions, which were further refined by electrospray ionization-mass spectrometry analysis of the brominated quasi-molecular ion clusters. This procedure led to either a single compound assignment, or a maximum of two possible isobaric compounds. The dereplication study indicated that the chemical profile of the 14 specimens of Aplysina spp. analyzed presented practically the same dibromotyrosine-derived compounds. The results obtained suggested a possible biogenetic pathway for the formation of dibromotyrosine-derived compounds of wide occurrence in Verongida sponges.

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