An Efficient Construction of Bicyclic Systems Containing a Seven-Membered Ring by Tandem Ring-Closing Metathesis Reactions of Dienynes.

ChemInform ◽  
2007 ◽  
Vol 38 (19) ◽  
Author(s):  
Francois-Didier Boyer ◽  
Issam Hanna
Keyword(s):  
Membered Ring ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions ◽  
Efficient Construction

Nickel-Catalyzed Inter- and Intramolecular Carbon-Sulfur Bond Metathesis by Reversible Arylation

2019 ◽  
Author(s):  
Tristan Delcaillau ◽  
Alessandro Bismuto ◽  
Zhong Lian ◽  
Bill Morandi
Keyword(s):  
Good Yield ◽  
Functional Group ◽  
Product Formation ◽  
Single Bond ◽  
Ring Closing Metathesis ◽  
Catalytic Systems ◽  
Metathesis Reactions ◽  
New Applications ◽  
Further Development ◽  
Sulfur Bond

A nickel-catalyzed carbon-sulfur bond metathesis has been developed to access high-value thioethers. 1,2-bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional group tolerant reaction. Further, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis which does not involve alkene bonds. In-depth organometallic studies support a reversible Ni(0)-Ni(II) pathway to product formation. Overall, this work does not only disclose a more sustainable and more functional group tolerant alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information which are highly relevant to the further development and application of unusual single bond metathesis reactions.

Diastereoselective double ring closing metathesis reactions as an approach to symmetrical bicyclodienes

2000 ◽  
Vol 78 (6) ◽  
pp. 868-883 ◽  
Author(s):  
Mark Lautens ◽  
Gregory Hughes ◽  
Valentin Zunic
Keyword(s):  
Ring Closing Metathesis ◽  
Double Ring ◽  
New Class ◽  
Wide Range ◽  
Metathesis Reactions ◽  
Bicyclic Dienes

A new class of bicyclic dienes which contain a σ plane of symmetry are efficiently prepared in a diastereoselective fashion using ring closing metathesis reactions. These molecules have potential as starting materials for a wide range of organic targets.Key words: metathesis, catalysis, stereoselective, decalin, desymmetrization.

An Enantio- and Diastereoselective Synthesis of Fluorinated β-Aminoalkyl­oxepine Derivatives through Mannich and Ring-Closing Metathesis Reactions

Synthesis ◽  
2006 ◽  
Vol 2006 (23) ◽  
pp. 4087-4091 ◽  
Author(s):  
Santos Fustero ◽  
Elisabet Esteban ◽  
Juan Sanz-Cervera ◽  
Diego Jiménez ◽  
Fatemeh Mojarrad
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

Generic synthesis of β-sultams via domino alkylation of bromomethanesulfonamides

2004 ◽  
Vol 82 (2) ◽  
pp. 113-119 ◽  
Author(s):  
William R Barton ◽  
Leo A Paquette
Keyword(s):  
Functional Groups ◽  
Potassium Carbonate ◽  
Membered Ring ◽  
Ring Closing Metathesis ◽  
Intramolecular Alkylation ◽  
Ketone Ester

Reaction of N-substituted bromomethanesulfonamides with 2 equiv of potassium carbonate and an α-halo ketone, ester, or nitrile leads directly to 3-substituted β-sultams. The first step is intermolecular and is followed by an intramolecular alkylation. The process is particularly efficient when diethyl bromomalonate and 3-chloro-2-butanone are involved. In the latter example, no competitive cyclization to form a six-membered ring is seen. The functional groups in certain of the β-sultam products can be subsequently manipulated to give bicyclic products.Key words: β-sultams, intramolecular SN2 displacement, sulfonamides, ring closing metathesis, four-membered heterocycles.

One-Pot Ring-Closing Metathesis-Alkene Cross Metathesis Reactions of Sulfamide-Linked Enynes

2004 ◽  
Vol 2004 (4) ◽  
pp. 800-806 ◽  
Author(s):  
Sofia S. Salim ◽  
Richard K. Bellingham ◽  
Richard C. D. Brown
Keyword(s):  
Ring Closing Metathesis ◽  
One Pot ◽  
Cross Metathesis ◽  
Metathesis Reactions

Concise synthesis of five-membered ring carbasugars based on key ring-closing metathesis

2010 ◽  
Vol 51 (29) ◽  
pp. 3848-3851 ◽  
Author(s):  
Ya-Xi Yang ◽  
Zheng Li ◽  
Hui-Jin Feng ◽  
Guo-Rong Chen ◽  
Yuan-Chao Li
Keyword(s):  
Membered Ring ◽  
Ring Closing Metathesis

Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives

2003 ◽  
Vol 46 (7) ◽  
pp. 1165-1179 ◽  
Author(s):  
Fredrik Thorstensson ◽  
Ingemar Kvarnström ◽  
Djordje Musil ◽  
Ingemar Nilsson ◽  
Bertil Samuelsson
Keyword(s):  
Thrombin Inhibitors ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

Synthesis of the C7-C17 Segment of Epothilones by a 10-membered Ring Closing Metathesis Reaction

Synlett ◽  
1998 ◽  
Vol 1998 (10) ◽  
pp. 1108-1110 ◽  
Author(s):  
Kai Gerlach ◽  
Monika Quitschalle ◽  
Markus Kalesse
Keyword(s):  
Membered Ring ◽  
Metathesis Reaction ◽  
Ring Closing Metathesis
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