Stereoselective Formal Synthesis of the Potent Proteasome Inhibitor Salinosporamide A (I).

ChemInform ◽  
2007 ◽  
Vol 38 (17) ◽  
Author(s):  
Virginie Caubert ◽  
Julien Masse ◽  
Pascal Retailleau ◽  
Nicole Langlois
Keyword(s):  
Proteasome Inhibitor ◽  
Formal Synthesis ◽  
Salinosporamide A

Stereoselective formal synthesis of the potent proteasome inhibitor: salinosporamide A

2007 ◽  
Vol 48 (3) ◽  
pp. 381-384 ◽  
Author(s):  
Virginie Caubert ◽  
Julien Massé ◽  
Pascal Retailleau ◽  
Nicole Langlois
Keyword(s):  
Proteasome Inhibitor ◽  
Formal Synthesis ◽  
Salinosporamide A

scholarly journals Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (−)-Salinosporamide A

2014 ◽  
Vol 16 (16) ◽  
pp. 4078-4081 ◽  
Author(s):  
Angus W. J. Logan ◽  
Simon J. Sprague ◽  
Robert W. Foster ◽  
Léo B. Marx ◽  
Vincenzo Garzya ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Formal Synthesis ◽  
Salinosporamide A

scholarly journals Salinosporamide A: A Highly Cytotoxic Proteasome Inhibitor from a Novel Microbial Source, a Marine Bacterium of the New Genus Salinospora

2003 ◽  
Vol 42 (3) ◽  
pp. 355-357 ◽  
Author(s):  
Robert H. Feling ◽  
Greg O. Buchanan ◽  
Tracy J. Mincer ◽  
Christopher A. Kauffman ◽  
Paul R. Jensen ◽  
...  
Keyword(s):  
Proteasome Inhibitor ◽  
Marine Bacterium ◽  
New Genus ◽  
Salinosporamide A

ChemInform Abstract: Diastereoselective Synthesis of Fused Lactone-Pyrrolidinones; Application to a Formal Synthesis of (-)-Salinosporamide A.

ChemInform ◽  
2015 ◽  
Vol 46 (7) ◽  
pp. no-no
Author(s):  
Angus W. J. Logan ◽  
Simon J. Sprague ◽  
Robert W. Foster ◽  
Leo B. Marx ◽  
Vincenzo Garzya ◽  
...  
Keyword(s):  
Diastereoselective Synthesis ◽  
Formal Synthesis ◽  
Salinosporamide A

scholarly journals Antileukemic Activity and Mechanism of Drug Resistance to the Marine Salinispora tropica Proteasome Inhibitor Salinosporamide A (Marizomib)

2014 ◽  
Vol 86 (1) ◽  
pp. 12-19 ◽  
Author(s):  
Denise Niewerth ◽  
Gerrit Jansen ◽  
Lesley F. V. Riethoff ◽  
Johan van Meerloo ◽  
Andrew J. Kale ◽  
...  
Keyword(s):  
Drug Resistance ◽  
Proteasome Inhibitor ◽  
Antileukemic Activity ◽  
Salinosporamide A ◽  
Salinispora Tropica

scholarly journals Selective Overproduction of the Proteasome Inhibitor Salinosporamide A via Precursor Pathway Regulation

2011 ◽  
Vol 18 (12) ◽  
pp. 1527-1536 ◽  
Author(s):  
Anna Lechner ◽  
Alessandra S. Eustáquio ◽  
Tobias A.M. Gulder ◽  
Mathias Hafner ◽  
Bradley S. Moore
Keyword(s):  
Proteasome Inhibitor ◽  
Salinosporamide A ◽  
Pathway Regulation

Formal Synthesis of Salinosporamide A Starting from d-Glucose

Synthesis ◽  
2009 ◽  
Vol 2009 (17) ◽  
pp. 2983-2991 ◽  
Author(s):  
Noritaka Chida ◽  
Takayuki Momose ◽  
Yuji Kaiya ◽  
Jun-ichi Hasegawa ◽  
Takaaki Sato
Keyword(s):  
Formal Synthesis ◽  
Salinosporamide A

Indium-catalyzed Conia-ene reaction for alkaloid synthesis

2009 ◽  
Vol 81 (2) ◽  
pp. 217-226 ◽  
Author(s):  
Susumi Hatakeyama
Keyword(s):  
Proteasome Inhibitor ◽  
20S Proteasome ◽  
Ene Reaction ◽  
Excellent Yield ◽  
Salinosporamide A ◽  
Alkaloid Synthesis ◽  
Synthetic Utility ◽  
Reaction Proceeds

In(OTf)3-catalyzed cyclization of nitrogen- and oxygen-tethered acetylenic malonic esters provides various five- to seven-membered heterocycles in moderate to excellent yield, and the reaction proceeds with no racemization and complete E-selectivity in the case of chiral and nonterminal alkynes. The synthetic utility is demonstrated by the synthesis of (-)-salinosporamide A, a highly potent 20S proteasome inhibitor, and (+)-neooxazolomycin, a member of the oxazolomycin family of antibiotics.

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