An Enantio- and Diastereoselective Synthesis of Fluorinated β-Aminoalkyloxepin Derivatives Through Mannich and Ring-Closing Metathesis Reactions.

ChemInform ◽  
2007 ◽  
Vol 38 (15) ◽  
Author(s):  
Santos Fustero ◽  
Elisabet Esteban ◽  
Juan F. Sanz-Cervera ◽  
Diego Jimenez ◽  
Fatemeh Mojarrad
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

An Enantio- and Diastereoselective Synthesis of Fluorinated β-Aminoalkyl­oxepine Derivatives through Mannich and Ring-Closing Metathesis Reactions

Synthesis ◽  
2006 ◽  
Vol 2006 (23) ◽  
pp. 4087-4091 ◽  
Author(s):  
Santos Fustero ◽  
Elisabet Esteban ◽  
Juan Sanz-Cervera ◽  
Diego Jiménez ◽  
Fatemeh Mojarrad
Keyword(s):  
Diastereoselective Synthesis ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

Nickel-Catalyzed Inter- and Intramolecular Carbon-Sulfur Bond Metathesis by Reversible Arylation

2019 ◽  
Author(s):  
Tristan Delcaillau ◽  
Alessandro Bismuto ◽  
Zhong Lian ◽  
Bill Morandi
Keyword(s):  
Good Yield ◽  
Functional Group ◽  
Product Formation ◽  
Single Bond ◽  
Ring Closing Metathesis ◽  
Catalytic Systems ◽  
Metathesis Reactions ◽  
New Applications ◽  
Further Development ◽  
Sulfur Bond

A nickel-catalyzed carbon-sulfur bond metathesis has been developed to access high-value thioethers. 1,2-bis(dicyclohexylphosphino)ethane (dcype) is essential to promote this highly functional group tolerant reaction. Further, synthetically challenging macrocycles could be obtained in good yield in an unusual example of ring-closing metathesis which does not involve alkene bonds. In-depth organometallic studies support a reversible Ni(0)-Ni(II) pathway to product formation. Overall, this work does not only disclose a more sustainable and more functional group tolerant alternative to previous catalytic systems based on Pd, but also presents new applications and mechanistic information which are highly relevant to the further development and application of unusual single bond metathesis reactions.

Diastereoselective double ring closing metathesis reactions as an approach to symmetrical bicyclodienes

2000 ◽  
Vol 78 (6) ◽  
pp. 868-883 ◽  
Author(s):  
Mark Lautens ◽  
Gregory Hughes ◽  
Valentin Zunic
Keyword(s):  
Ring Closing Metathesis ◽  
Double Ring ◽  
New Class ◽  
Wide Range ◽  
Metathesis Reactions ◽  
Bicyclic Dienes

A new class of bicyclic dienes which contain a σ plane of symmetry are efficiently prepared in a diastereoselective fashion using ring closing metathesis reactions. These molecules have potential as starting materials for a wide range of organic targets.Key words: metathesis, catalysis, stereoselective, decalin, desymmetrization.

One-Pot Ring-Closing Metathesis-Alkene Cross Metathesis Reactions of Sulfamide-Linked Enynes

2004 ◽  
Vol 2004 (4) ◽  
pp. 800-806 ◽  
Author(s):  
Sofia S. Salim ◽  
Richard K. Bellingham ◽  
Richard C. D. Brown
Keyword(s):  
Ring Closing Metathesis ◽  
One Pot ◽  
Cross Metathesis ◽  
Metathesis Reactions

Synthesis of Novel Thrombin Inhibitors. Use of Ring-Closing Metathesis Reactions for Synthesis of P2 Cyclopentene- and Cyclohexenedicarboxylic Acid Derivatives

2003 ◽  
Vol 46 (7) ◽  
pp. 1165-1179 ◽  
Author(s):  
Fredrik Thorstensson ◽  
Ingemar Kvarnström ◽  
Djordje Musil ◽  
Ingemar Nilsson ◽  
Bertil Samuelsson
Keyword(s):  
Thrombin Inhibitors ◽  
Ring Closing Metathesis ◽  
Metathesis Reactions

scholarly journals Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Synthesis ◽  
2019 ◽  
Vol 51 (05) ◽  
pp. 1100-1114 ◽  
Author(s):  
Emilia Groso ◽  
Corinna Schindler
Keyword(s):  
Olefin Metathesis ◽  
Nitrogen Heterocycles ◽  
Short Review ◽  
Catalyst Design ◽  
Carbene Ligands ◽  
Ring Closing Metathesis ◽  
Recent Advances ◽  
Metathesis Reactions

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.1 Introduction2 Expansion of Ring-Closing Metathesis Methods3 Evaluation of Catalyst Design4 Indenylidene Catalysts5 Unsymmetrical N-Heterocyclic Carbene Ligands6 Carbonyl-Olefin Metathesis7 Conclusions

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