Total Syntheses of Bioactive Natural Products from Carbohydrates

ChemInform ◽  
2007 ◽  
Vol 38 (12) ◽  
Author(s):  
Kuniaki Tatsuta ◽  
Seijiro Hosokawa
Keyword(s):  
Natural Products ◽  
Total Syntheses ◽  
Bioactive Natural Products

Total syntheses of polyketide-derived bioactive natural products

2006 ◽  
Vol 6 (4) ◽  
pp. 217-233 ◽  
Author(s):  
Kuniaki Tatsuta ◽  
Seijiro Hosokawa
Keyword(s):  
Natural Products ◽  
Total Syntheses ◽  
Bioactive Natural Products

Total Syntheses of Polyketide-Derived Bioactive Natural Products

ChemInform ◽  
2007 ◽  
Vol 38 (11) ◽  
Author(s):  
Kuniaki Tatsuta ◽  
Seijiro Hosokawa
Keyword(s):  
Natural Products ◽  
Total Syntheses ◽  
Bioactive Natural Products

Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

2015 ◽  
Vol 32 (4) ◽  
pp. 605-632 ◽  
Author(s):  
Michail Tsakos ◽  
Eva S. Schaffert ◽  
Lise L. Clement ◽  
Nikolaj L. Villadsen ◽  
Thomas B. Poulsen
Keyword(s):  
Natural Products ◽  
Chemical Synthesis ◽  
Natural Product ◽  
Organic Synthesis ◽  
State Of The Art ◽  
The State ◽  
Coupling Reactions ◽  
Total Syntheses ◽  
Bioactive Natural Products ◽  
Complex Ester

In this review we investigate the use of complex ester fragment couplings within natural product total syntheses. Using examples from the literature up to 2014 we illustrate the state-of-the-art as well as the challenges within this area of organic synthesis.

Procedure-Economical, Enantioselective Total Syntheses of Polycyclic Natural Products and Analogues Containing a 3a-Hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic Acid Residue

Synlett ◽  
2020 ◽  
Vol 31 (17) ◽  
pp. 1681-1690
Author(s):  
Pei-Qiang Huang
Keyword(s):  
Natural Products ◽  
Carboxylic Acid ◽  
Tandem Reactions ◽  
Protecting Group ◽  
Future Perspectives ◽  
Total Syntheses ◽  
Bioactive Natural Products ◽  
Regioselective Reactions ◽  
Enantioselective Syntheses

The 3a-hydroxyhexahydropyrrolo[2,3-b]indole-2-carboxylic acid (HPIC) residue and its aza-analogue are found in many bioactive natural products. In this account, short divergent total syntheses of several such natural products, diastereomers and analogues are described. It is demonstrated that by appropriate combination of different efficient tactics such as biomimetic/bio-inspired synthesis, chemo/regioselective reactions, umpolung of regioselectivity and/or reactivity, and tandem reactions, the enantioselective syntheses of polycyclic molecules such as (+)-asperlicin E and (–)-robustanoids A and B can be achieved in a protecting-group-free and redox-economical manner, in only three to four steps starting from l-tryptophan.1 Introduction2 Strategic Considerations2.1 Occurrence of HO-HPIC and HO-aza-HPIC Residues in Natural Products2.2 Biosyntheses of HO-HPIC and HO-aza-HPIC Residues2.3 Chemical Syntheses of HO-HPIC and HO-aza-HPIC Residues3 Procedure-Economical Syntheses of HO-HPIC-Containing Natural Products3.1 Protecting-Group-Free Syntheses of Asperlicin E, Its Diastereomer, and an Analogue3.2 Divergent Syntheses of (–)-Robustanoids A and B, a Diastereomer, and Analogues4 Conclusion and Future Perspectives

Biotransformations of Bioactive Natural Products with Complicated Structures

Planta Medica ◽  
2012 ◽  
Vol 78 (05) ◽  
Author(s):  
JG Dai ◽  
RD Chen ◽  
D Xie ◽  
JH Li ◽  
K Wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Bioactive Natural Products
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