Novel Synthetic Methodologies. Part 112. An Efficient Catalyst-Free Synthesis of Thiiranes from Oxiranes Using Polyethylene Glycol as the Reaction Medium.

ChemInform ◽  
2007 ◽  
Vol 38 (12) ◽  
Author(s):  
Biswanath Das ◽  
V. Saidi Reddy ◽  
M. Krishnaiah
Keyword(s):  
Polyethylene Glycol ◽  
Reaction Medium ◽  
Efficient Catalyst ◽  
Catalyst Free ◽  
Synthetic Methodologies

Polyethylene Glycol as a Green and Biocompatible Reaction Media for the Catalyst Free Synthesis of Organic Compounds

2020 ◽  
Vol 24 (12) ◽  
pp. 1275-1314
Author(s):  
Rezvan Kardooni ◽  
Ali Reza Kiasat
Keyword(s):  
Polyethylene Glycol ◽  
Green Chemistry ◽  
Organic Compounds ◽  
Reaction Medium ◽  
Focal Points ◽  
Organic Reaction ◽  
Considerable Contribution ◽  
Catalyst Free ◽  
Current Review ◽  
Reaction Media

Replacing harmful organic solvents that caused environmental pollution with an alternative medium for the development of ideal synthetic strategies is one of the primary focal points of green chemistry. Utilizing polyethylene glycol (PEG) as a nonvolatile solvent and promotor for the evaluation of safe processes has made a considerable contribution to the reduction of pollution problems. The current review summarizes the recent well-known catalyst-free organic reaction performed in polyethylene glycol as a green and biocompatible reaction medium.

scholarly journals A Combined Synthetic and DFT Study on the Catalyst-Free and Solvent-Assisted Synthesis of 1,3,4-Oxadiazole-2-thiol Derivatives

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Mohammad Soleiman-Beigi ◽  
Reza Aryan ◽  
Maryam Yousofizadeh ◽  
Shima Khosravi
Keyword(s):  
Field Theory ◽  
Ab Initio ◽  
Solvent Effects ◽  
Reaction Medium ◽  
Theoretical Studies ◽  
Product Selectivity ◽  
Efficient Catalyst ◽  
Reaction Field ◽  
Effect Of Solvents ◽  
Catalyst Free

A novel practical and efficient catalyst-free method for the synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols has been developed, which is assisted by reaction solvent (DMF). The solvent effects on product selectivity were studied based on Onsager’s reaction field theory of electrostatic solvation. The ab initio theoretical studies on the effect of solvents on the process also supported the suitability of DMF as the reaction medium for the preparation of 1,3,4-oxadiazole-2-thiol derivatives.

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