Rational Design and Convenient Synthesis of a Novel Family of Ruthenium Complexes with O,N-Bidentate Ligands

ChemInform ◽  
2006 ◽  
Vol 37 (39) ◽  
Author(s):  
Renate Drozdzak ◽  
Nele Ledoux ◽  
Bart Allaert ◽  
Ileana Dragutan ◽  
Valerian Dragutan ◽  
...  
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes ◽  
Bidentate Ligands ◽  
Convenient Synthesis

scholarly journals Rational design and convenient synthesis of a novel family of ruthenium complexes with O,N-bidentate ligands

2005 ◽  
Vol 3 (3) ◽  
pp. 404-416 ◽  
Author(s):  
Renate Drozdzak ◽  
Nele Ledoux ◽  
Bart Allaert ◽  
Ileana Dragutan ◽  
Valerian Dragutan ◽  
...  
Keyword(s):  
Schiff Bases ◽  
Rational Design ◽  
Chemical Properties ◽  
13C Nmr Spectroscopy ◽  
Synthetic Approach ◽  
Bidentate Ligands ◽  
Step Procedure ◽  
Convenient Synthesis ◽  
Ru Complexes ◽  
Physical And Chemical

AbstractA two step procedure for the synthesis of a novel family of homogeneous and immobilized Ru-complexes containing Schiff bases as O,N-bidentate ligands is described. The new Ru-complexes have been structurally characterized by IR, Raman,1H-,13C-NMR spectroscopy. The Schiff bases were associated with a diversity of inorganic and organic ligands such as chloride, phosphane, arenes, various carbenes (alkylidene, vinylidene, indenylidene and allenylidene as well as N-heterocyclic carbenes) and cyclodienes. By choosing a selective range of substituents for the Schiff base, useful physical and chemical properties of the prepared Rucomplexes can be induced. This synthetic approach is promising in creating a valuable and diverse selection of Ru-complexes, valuable for future applications.

A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling

2015 ◽  
Vol 51 (13) ◽  
pp. 2637-2640 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complex ◽  
Ruthenium Complexes

We have described the rational design of selenium-containing ruthenium complexes and their use as cancer radiosensitizers through regulating ROS-mediated pathways.

scholarly journals The Combination of 4-Hydroxythiazoles with Azaheterocycles: Efficient Bidentate Ligands for Novel Ruthenium Complexes

2010 ◽  
Vol 636 (7) ◽  
pp. 1380-1385 ◽  
Author(s):  
Roberto Menzel ◽  
Eric Täuscher ◽  
Dieter Weiß ◽  
Rainer Beckert ◽  
Helmar Görls
Keyword(s):  
Ruthenium Complexes ◽  
Bidentate Ligands

Rational Design of Ruthenium Complexes Containing 2,6-Bis(benzimidazolyl)pyridine Derivatives with Radiosensitization Activity by Enhancing p53 Activation

ChemMedChem ◽  
2015 ◽  
Vol 10 (6) ◽  
pp. 991-998 ◽  
Author(s):  
Zhiqin Deng ◽  
Lianling Yu ◽  
Wenqiang Cao ◽  
Wenjie Zheng ◽  
Tianfeng Chen
Keyword(s):  
Rational Design ◽  
Ruthenium Complexes ◽  
Pyridine Derivatives ◽  
P53 Activation

Rhodium and Ruthenium Complexes with Optically Active Chelate Cyclopentadienyl-Phosphine Bidentate Ligands

1995 ◽  
Vol 24 (9) ◽  
pp. 833-834 ◽  
Author(s):  
Yasutaka Kataoka ◽  
Yoshinori Saito ◽  
Koji Nagata ◽  
Kenichi Kitamura ◽  
Atsushi Shibahara ◽  
...  
Keyword(s):  
Ruthenium Complexes ◽  
Optically Active ◽  
Bidentate Ligands

scholarly journals C,C- and C,N-Chelated Organocopper Compounds

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5806
Author(s):  
Liang Liu ◽  
Hui Chen ◽  
Zhenqiang Yang ◽  
Junnian Wei ◽  
Zhenfeng Xi
Keyword(s):  
Rational Design ◽  
Deep Understanding ◽  
Ion Pair ◽  
Bidentate Ligand ◽  
Macrocyclic Compounds ◽  
Bidentate Ligands ◽  
Function Relationship ◽  
Cyclic Compounds ◽  
Relationship Of ◽  
Structural Characterizations

Copper-catalyzed and organocopper-involved reactions are of great significance in organic synthesis. To have a deep understanding of the reaction mechanisms, the structural characterizations of organocopper intermediates become indispensable. Meanwhile, the structure-function relationship of organocopper compounds could advance the rational design and development of new Cu-based reactions and organocopper reagents. Compared to the mono-carbonic ligand, the C,N- and C,C-bidentate ligands better stabilize unstable organocopper compounds. Bidentate ligands can chelate to the same copper atom via η2-mode, forming a mono-cupra-cyclic compounds with at least one acute C-Cu-C angle. When the bidentate ligands bind to two copper atoms via η1-mode at each coordinating site, the bimetallic macrocyclic compounds will form nearly linear C-Cu-C angles. The anionic coordinating sites of the bidentate ligand can also bridge two metals via μ2-mode, forming organocopper aggregates with Cu-Cu interactions and organocuprates with contact ion pair structures. The reaction chemistry of some selected organocopper compounds is highlighted, showing their unique structure–reactivity relationships.

Synthesis of iridium and ruthenium complexes with (N,N), (N,O) and (O,O) coordinating bidentate ligands as potential anti-cancer agents

2012 ◽  
Vol 41 (45) ◽  
pp. 13800 ◽  
Author(s):  
Stephanie J. Lucas ◽  
Rianne M. Lord ◽  
Rachel L. Wilson ◽  
Roger M. Phillips ◽  
Visuvanathar Sridharan ◽  
...  
Keyword(s):  
Ruthenium Complexes ◽  
Bidentate Ligands ◽  
Anti Cancer

Synthesis of ruthenium complexes with planar-chiral cyclopentadienyl-pyridine or -phosphine bidentate ligands

2000 ◽  
pp. 35-41 ◽  
Author(s):  
Noriko Dodo ◽  
Yuji Matsushima ◽  
Mitsunari Uno ◽  
Kiyotaka Onitsuka ◽  
Shigetoshi Takahashi
Keyword(s):  
Ruthenium Complexes ◽  
Bidentate Ligands
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