Design and Synthesis of 2,3,4,9-Tetrahydro-1H-carbazole and 1,2,3,4-Tetrahydro-cyclopenta[b]indole Derivatives as Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase.

ChemInform ◽  
2006 ◽  
Vol 37 (31) ◽  
Author(s):  
Ariamala Gopalsamy ◽  
Mengxiao Shi ◽  
Gregory Ciszewski ◽  
Kaapjoo Park ◽  
John W. Ellingboe ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Indole Derivatives ◽  
Rna Dependent Rna Polymerase ◽  
Design And Synthesis ◽  
Nucleoside Inhibitors

New Non-nucleoside Inhibitors of Hepatitis C Virus RNA-Dependent RNA Polymerase

2004 ◽  
Vol 69 (7) ◽  
pp. 782-788 ◽  
Author(s):  
A. V. Ivanov ◽  
M. V. Kozlov ◽  
A. O. Kuzyakin ◽  
D. A. Kostyuk ◽  
V. L. Tunitskaya ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Hepatitis C Virus Rna ◽  
Rna Dependent Rna Polymerase ◽  
Virus Rna ◽  
Nucleoside Inhibitors

Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

2012 ◽  
Vol 55 (6) ◽  
pp. 2481-2531 ◽  
Author(s):  
Michael J. Sofia ◽  
Wonsuk Chang ◽  
Phillip A. Furman ◽  
Ralph T. Mosley ◽  
Bruce S. Ross
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Rna Dependent Rna Polymerase ◽  
Nucleoside Inhibitors

Potential Inhibition of COVID-19 RNA-dependent RNA Polymerase by Hepatitis C Virus Non-nucleoside Inhibitors: An In-silico Perspective

2020 ◽  
Vol 17 ◽  
Author(s):  
Yee Siew Choong ◽  
Theam Soon Lim ◽  
Hanyun Liu ◽  
Rubin Jiang ◽  
Zimu Cai ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Binding Sites ◽  
Homology Modelling ◽  
Clinical Importance ◽  
Rna Dependent Rna Polymerase ◽  
Nucleoside Inhibitors

Background: Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a novel member of the genus betacoronavirus in the Coronaviridae family. It has been identified as the causative agent of coronavirus disease 2019 (COVID-19) spreading rapidly in Asia, America and Europe. Like some other RNA viruses, RNA replication and transcription of SARS-CoV-2 relies on its RNA-dependent RNA polymerase (RdRP), which is a therapeutic target of clinical importance. Crystal structure of SARS-CoV-2 that was solved recently (PDB ID 6M71) with some missing residues. Objective: We used SARS-CoV-2 RdRP as a target protein to screen for possible chemical molecules with potential antiviral effects. Method: Here we modelled the missing residues 896-905 via homology modelling and then analysed the interactions of Hepatitis C virus allosteric non-nucleoside inhibitors (NNIs) in the reported NNIs binding sites in SARS-CoV-2 RdRP. Results and Discussion: We found that MK-3281, filibuvir, setrobuvir and dasabuvir might be able to inhibit SARS-CoV-2 RdRP based on their binding affinities in the respective binding sites. Conclusion: Further in vitro and in vivo experimental research will be carried out to evaluate their effectiveness in COVID19 treatment in the near future.

Novel 4-Thiazolidinones as Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA Polymerase

2014 ◽  
Vol 348 (1) ◽  
pp. 10-22 ◽  
Author(s):  
Gizem Çakır ◽  
İlkay Küçükgüzel ◽  
Rupa Guhamazumder ◽  
Esra Tatar ◽  
Dinesh Manvar ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Rna Dependent Rna Polymerase ◽  
Nucleoside Inhibitors

Correction to Nucleoside, Nucleotide, and Non-Nucleoside Inhibitors of Hepatitis C Virus NS5B RNA-Dependent RNA-Polymerase

2017 ◽  
Vol 60 (7) ◽  
pp. 3219-3219
Author(s):  
Michael J. Sofia ◽  
Wonsuk Chang ◽  
Phillip A. Furman ◽  
Ralph T. Mosley ◽  
Bruce S. Ross
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Rna Polymerase ◽  
Rna Dependent Rna Polymerase ◽  
Nucleoside Inhibitors
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