Discovery of Immature Thymocyte Proliferation Factor

ChemInform ◽  
2006 ◽  
Vol 37 (26) ◽  
Author(s):  
Yasuhiro Kohama
Keyword(s):  
Thymocyte Proliferation ◽  
Immature Thymocyte

Induction of immature thymocyte proliferation after castration of normal male mice.

Endocrinology ◽  
1994 ◽  
Vol 134 (1) ◽  
pp. 107-113 ◽  
Author(s):  
N J Olsen ◽  
S M Viselli ◽  
K Shults ◽  
G Stelzer ◽  
W J Kovacs
Keyword(s):  
Normal Male ◽  
Male Mice ◽  
Thymocyte Proliferation ◽  
Immature Thymocyte

scholarly journals Discovery of Immature Thymocyte Proliferation Factor

2006 ◽  
Vol 126 (3) ◽  
pp. 145-160 ◽  
Author(s):  
Yasuhiro KOHAMA
Keyword(s):  
Thymocyte Proliferation ◽  
Immature Thymocyte

scholarly journals Differential interleukin-1 elaboration by density-defined human monocyte subpopulations

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 298-301
Author(s):  
JA Elias ◽  
P Chien ◽  
KM Gustilo ◽  
AD Schreiber
Keyword(s):  
Human Blood ◽  
Interleukin 1 ◽  
Human Monocyte ◽  
Mononuclear Phagocytes ◽  
Blood Monocyte ◽  
Thymocyte Proliferation ◽  
Percoll Gradients ◽  
Human Blood Monocyte ◽  
Monocytes And Macrophages ◽  
Monocyte Subpopulations

Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.

Immature thymocyte antigen, JL1, as a possible immunodiagnostic and immunotherapeutic target for leukemia

2001 ◽  
Vol 1 (1) ◽  
pp. 1
Author(s):  
Young Kee Shin ◽  
Eun Young Choi ◽  
Seok Hyung Kim ◽  
Seong Hoe Park
Keyword(s):  
Immature Thymocyte

scholarly journals Differential interleukin-1 elaboration by density-defined human monocyte subpopulations

Blood ◽  
1985 ◽  
Vol 66 (2) ◽  
pp. 298-301 ◽  
Author(s):  
JA Elias ◽  
P Chien ◽  
KM Gustilo ◽  
AD Schreiber
Keyword(s):  
Human Blood ◽  
Interleukin 1 ◽  
Human Monocyte ◽  
Mononuclear Phagocytes ◽  
Blood Monocyte ◽  
Thymocyte Proliferation ◽  
Percoll Gradients ◽  
Human Blood Monocyte ◽  
Monocytes And Macrophages ◽  
Monocyte Subpopulations

Abstract Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.

Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro

2006 ◽  
Vol 36 (1) ◽  
pp. 160-169 ◽  
Author(s):  
Tina M. Thornton ◽  
Alfred J. Zullo ◽  
Kristi L. Williams ◽  
Elizabeth J. Taparowsky
Keyword(s):  
Activator Protein 1 ◽  
Direct Manipulation ◽  
Activator Protein ◽  
Thymocyte Proliferation ◽  
Proliferation In Vitro
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