Synthesis of Poison Frog Alkaloids: Novel, Potent and Subtype-Selective Blockers of Neuronal Nicotinic Acetylcholine Receptors

Naoki Toyooka; Hideo Nemoto; Hiroshi Tsuneki

doi:10.1002/chin.200624267

Synthesis of Poison Frog Alkaloids: Novel, Potent and Subtype-Selective Blockers of Neuronal Nicotinic Acetylcholine Receptors

ChemInform ◽

10.1002/chin.200624267 ◽

2006 ◽

Vol 37 (24) ◽

Author(s):

Naoki Toyooka ◽

Hideo Nemoto ◽

Hiroshi Tsuneki

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Poison Frog ◽

Subtype Selective

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Synthesis of Poison Frog Alkaloids : Novel, Potent and Subtype-selective Blockers of Neuronal Nicotinic Acetylcholine Receptors

Journal of Synthetic Organic Chemistry Japan ◽

10.5059/yukigoseikyokaishi.64.49 ◽

2006 ◽

Vol 64 (1) ◽

pp. 49-60 ◽

Cited By ~ 7

Author(s):

Naoki Toyooka ◽

Hideo Nemoto ◽

Hiroshi Tsuneki

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Poison Frog ◽

Subtype Selective

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Syntheses of the Proposed Structures of Poison-Frog Alkaloids 179 and 207E and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors

Synlett ◽

10.1055/s-2007-1000831 ◽

2008 ◽

Vol 2008 (1) ◽

pp. 61-64 ◽

Cited By ~ 9

Author(s):

Naoki Toyooka ◽

Dejun Zhou ◽

Soushi Kobayashi ◽

Hiroshi Tsuneki ◽

Tsutomu Wada ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Inhibitory Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

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Flexible Synthesis of Poison-Frog Alkaloids of the 5,8-Disubstituted Indolizidine-Class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B”, (-)-221I, and an Epimer of 193E and Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors

Organic Chemistry ◽

10.1201/b12874-20 ◽

2011 ◽

pp. 197-206

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Class Ii ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Pharmacological Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text

ChemInform Abstract: Syntheses of the Proposed Structures of Poison-Frog Alkaloids 179 (Ia) and 207E (Ib) and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors.

ChemInform ◽

10.1002/chin.200821193 ◽

2008 ◽

Vol 39 (21) ◽

Author(s):

Naoki Toyooka ◽

et al. et al.

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Inhibitory Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

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Subtype-Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Cocaine Is Determined by the α4 and β4 Subunits

Molecular Pharmacology ◽

10.1124/mol.58.1.109 ◽

2000 ◽

Vol 58 (1) ◽

pp. 109-119 ◽

Cited By ~ 23

Author(s):

Michael M. Francis ◽

Raymond W. Vazquez ◽

Roger L. Papke ◽

Robert E. Oswald

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Selective Inhibition ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Nicotinic Acetylcholine ◽

Subtype Selective

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ChemInform Abstract: Synthesis of Poison-Frog Alkaloids 233A, 235U, and 251AA and Their Inhibitory Effects on Neuronal Nicotinic Acetylcholine Receptors.

ChemInform ◽

10.1002/chin.200807174 ◽

2008 ◽

Vol 39 (7) ◽

Author(s):

Naoki Toyooka ◽

et al. et al.

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Inhibitory Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text

ChemInform Abstract: Synthesis of Poison-Frog Alkaloids and Their Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors

ChemInform ◽

10.1002/chin.200801253 ◽

2008 ◽

Vol 39 (1) ◽

Author(s):

Naoki Toyooka ◽

Hiroshi Tsuneki ◽

Soushi Kobayashi ◽

Dejun Zhou ◽

Masashi Kawasaki ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Pharmacological Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text

Synthesis of Poison-Frog Alkaloids and Their Pharmacological Effects at Neuronal Nicotinic Acetylcholine Receptors

Current Chemical Biology ◽

10.2174/2212796810701010097 ◽

2007 ◽

Vol 1 (1) ◽

pp. 97-114

Author(s):

Naoki Toyooka ◽

Hiroshi Tsuneki ◽

Soushi Kobayashi ◽

Zhou Dejun ◽

Masashi Kawasaki ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Pharmacological Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text

Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2007.08.045 ◽

2007 ◽

Vol 17 (21) ◽

pp. 5872-5875 ◽

Cited By ~ 22

Author(s):

Naoki Toyooka ◽

Soushi Kobayashi ◽

Dejun Zhou ◽

Hiroshi Tsuneki ◽

Tsutomu Wada ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Inhibitory Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors

Beilstein Journal of Organic Chemistry ◽

10.1186/1860-5397-3-30 ◽

2007 ◽

Vol 3 ◽

Cited By ~ 11

Author(s):

Soushi Kobayashi ◽

Naoki Toyooka ◽

Dejun Zhou ◽

Hiroshi Tsuneki ◽

Tsutomu Wada ◽

...

Keyword(s):

Nicotinic Acetylcholine Receptors ◽

Acetylcholine Receptors ◽

Class Ii ◽

Neuronal Nicotinic Acetylcholine Receptors ◽

Pharmacological Effects ◽

Nicotinic Acetylcholine ◽

Poison Frog

Download Full-text