Advancing Chemistry and Biology Through Diversity-Oriented Synthesis of Natural Product-Like Libraries

ChemInform ◽  
2006 ◽  
Vol 37 (23) ◽  
Author(s):  
Shiying Shang ◽  
Derek S. Tan
Keyword(s):  
Natural Product ◽  
Diversity Oriented Synthesis

Diversity Oriented Synthesis and Branching Reaction Pathway to Generate Natural Product-like Compounds

2003 ◽  
Vol 10 (21) ◽  
pp. 2285-2316 ◽  
Author(s):  
Yun Liao ◽  
Youhong Hu ◽  
Jie Wu ◽  
Qiang Zhu ◽  
Maryann Donovan ◽  
...  
Keyword(s):  
Natural Product ◽  
Reaction Pathway ◽  
Diversity Oriented Synthesis

A diversity oriented synthesis of natural product inspired molecular libraries

2017 ◽  
Vol 15 (43) ◽  
pp. 9108-9120 ◽  
Author(s):  
Jyoti Chauhan ◽  
Tania Luthra ◽  
Rambabu Gundla ◽  
Antonio Ferraro ◽  
Ulrike Holzgrabe ◽  
...  
Keyword(s):  
Methyl Ester ◽  
Natural Product ◽  
Diversity Oriented Synthesis ◽  
Molecular Libraries ◽  
Tryptophan Methyl Ester

Diversity oriented synthesis of natural product inspired compounds from S-tryptophan methyl ester.

Natural Product Inspired Diversity Oriented Synthesis of Tetrahydroquinoline Scaffolds as Antitubercular Agent

2010 ◽  
Vol 13 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Atul Kumar ◽  
Suman Srivastava ◽  
Garima Gupta ◽  
Vinita Chaturvedi ◽  
Sudhir Sinha ◽  
...  
Keyword(s):  
Natural Product ◽  
Diversity Oriented Synthesis

scholarly journals Diversity-Oriented Synthesis: Amino Acetophenones as Building Blocks for the Synthesis of Natural Product Analogs

2021 ◽  
Vol 14 (11) ◽  
pp. 1127
Author(s):  
Mathias Eymery ◽  
Viet-Khoa Tran-Nguyen ◽  
Ahcène Boumendjel
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
Organic Synthesis ◽  
Building Blocks ◽  
Structural Features ◽  
The Other ◽  
Pharmacological Properties ◽  
Diversity Oriented Synthesis ◽  
Fully Integrated ◽  
Lead Compounds

Diversity-Oriented Synthesis (DOS) represents a strategy to obtain molecule libraries with diverse structural features starting from one common compound in limited steps of synthesis. During the last two decades, DOS has become an unmissable strategy in organic synthesis and is fully integrated in various drug discovery processes. On the other hand, natural products with multiple relevant pharmacological properties have been extensively investigated as scaffolds for ligand-based drug design. In this article, we report the amino dimethoxyacetophenones that can be easily synthesized and scaled up from the commercially available 3,5-dimethoxyaniline as valuable starting blocks for the DOS of natural product analogs. More focus is placed on the synthesis of analogs of flavones, coumarins, azocanes, chalcones, and aurones, which are frequently studied as lead compounds in drug discovery.

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