Porous Calcium Hydroxyapatite as an Efficient Catalyst for Synthesis of Pyrazolines via 1,3-Dipolar Cycloaddition under Solvent-Free Microwave Irradiation.

ChemInform ◽  
2006 ◽  
Vol 37 (23) ◽  
Author(s):  
R. Atir ◽  
S. Mallouk ◽  
K. Bougrin ◽  
M. Soufiaoui ◽  
A. Laghzizil
Keyword(s):  
Microwave Irradiation ◽  
Calcium Hydroxyapatite ◽  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Efficient Catalyst

1,3-Dipolar Cycloaddition of Nitriles under Microwave Irradiation in Solvent-Free Conditions

Heterocycles ◽  
1996 ◽  
Vol 43 (5) ◽  
pp. 1021 ◽  
Author(s):  
Angel Díaz-Ortiz ◽  
Enrique Díez-Barra ◽  
Antonio de la Hoz ◽  
Andrés Moreno ◽  
Maria J. Gómez-Escalonilla ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Solvent Free Conditions

A Microwave Accelerated Sustainable Approach for the Synthesis of 2-amino-4H-chromenes Catalysed by WEPPA: A Green Strategy

2019 ◽  
Vol 6 (1) ◽  
pp. 30-43 ◽  
Author(s):  
Prashant B. Hiremath ◽  
Kantharaju Kamanna
Keyword(s):  
Microwave Irradiation ◽  
Water Extract ◽  
Solvent Free ◽  
Present Approach ◽  
Pomegranate Peel ◽  
Efficient Catalyst ◽  
Ability To Act ◽  
Simple Filtration ◽  
Catalytic Medium ◽  
Aryl Aldehyde

Background: The agricultural wastes as a source offer an excellent alternative to replace many toxic and environmentally hazardous catalysts, due to their least toxicity, ease of biodegradability, and ability to act as a greener catalytic medium. Some of the agro-waste based catalysts reported are BFE, WERSA, WEB, and WEPBA. 2-Amino-4H-chromene derivatives are promising biologically potent heterocyclic compounds, due to their medicinal applications such as antimicrobial, anti-inflammatory, antibacterial, antiviral, anticancer, antidiuretic, anticoagulant and antianaphylactic activities. The present work describes a microwave accelerated, efficient, eco-friendly and economical approach for the synthesis of 2-amino-4H-chromenes through condensation of substituted arylaldehyde, malononitrile and resorcinol/naphthol catalyzed water extract of pomegranate peel ash (WEPPA) under microwave irradiation. The reaction completed within 3-6 min with good to excellent yield of product isolation. The final product isolated by simple filtration and recrystallization gave a spectroscopically pure form of product and did not require further purification. Methods: The pomegranate peel ash water extract as an agro-waste derived catalyst was employed under microwave irradiation for the economical synthesis of 2-amino-4H-chromene derivatives. Results: The reported agro-waste based catalyst was obtained in the absence of external base, additives and solvent-free synthesis of 2-amino-4H-chromene using aryl aldehyde, malononitrile and resorcinol/ naphthol under microwave irradiation. WEPPA acts as a solvent media and catalyst, as it plays a dual role in the synthesis of 2-amino-4H-chromenes. Conclusion: We established an efficient, simple, agro-waste based catalytic approach for the synthesis of 2-amino-4H-chromene derivatives from the condensation of arylaldehyde, malononitrile and resorcinol/α-naphthol/β-naphthol employing WEPPA as an efficient catalyst under microwave synthesis. The method has found to be a greener, economic and eco-friendly approach for the synthesis of chromene scaffolds. The advantages of the present approach are solvent-free, no external metal, chemical base free, short reaction time and isolated product in good to excellent yields. The catalyst is agro-waste derived, which has abundant natural sources available, thus making the present approach a greener one.

ChemInform Abstract: 1,3-Dipolar Cycloaddition of Nitriles under Microwave Irradiation in Solvent-Free Conditions.

ChemInform ◽  
2010 ◽  
Vol 27 (38) ◽  
pp. no-no
Author(s):  
A. DIAZ-ORTIZ ◽  
E. DIEZ-BARRA ◽  
A. DE LA HOZ ◽  
A. MORENO ◽  
M. J. GOMEZ-ESCALONILLA ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Solvent Free ◽  
Dipolar Cycloaddition ◽  
Solvent Free Conditions
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