A Novel Synthesis of New 3-Aryl-7-methylpyrano[4,3-b]pyran-4H,5H-diones Using Hypervalent Iodine(III) Reagents.

ChemInform ◽  
2006 ◽  
Vol 37 (20) ◽  
Author(s):  
Om Prakash ◽  
Ajay Kumar ◽  
Anil K. Sadana ◽  
Shiv P. Singh
Keyword(s):  
Hypervalent Iodine ◽  
Novel Synthesis

ChemInform Abstract: Hypervalent Iodine Oxidation of o-Aminochalcones: A Novel Synthesis of 3-(β-Styryl)-2,1-benzisoxazoles.

ChemInform ◽  
2010 ◽  
Vol 28 (33) ◽  
pp. no-no
Author(s):  
O. PRAKASH ◽  
R. K. SAINI ◽  
S. P. SINGH ◽  
R. S. VARMA
Keyword(s):  
Hypervalent Iodine ◽  
Novel Synthesis

Hypervalent iodine oxidation of o-aminochalcones: A novel synthesis of 3-(β-styryl)-2,1-benzisoxazoles

1997 ◽  
Vol 38 (18) ◽  
pp. 3147-3150 ◽  
Author(s):  
Om Prakash ◽  
Rajesh K. Saini ◽  
Shiv P. Singh ◽  
Rajender S. Varma
Keyword(s):  
Hypervalent Iodine ◽  
Novel Synthesis

A Novel Synthesis of New 3-Aryl-7-methylpyrano[4,3-b]pyran-4H,5H-diones Using Hypervalent Iodine(III) Reagents

Synthesis ◽  
2006 ◽  
Vol 2006 (01) ◽  
pp. 21-23 ◽  
Author(s):  
Om Prakash ◽  
Anil K. Sadana ◽  
Ajay Kumar ◽  
Shiv P. Singh
Keyword(s):  
Hypervalent Iodine ◽  
Novel Synthesis

Oxidase Catalysis via an Aerobically Generated Dess-Martin Periodinane Analogue

2018 ◽  
Author(s):  
Asim Maity ◽  
Sung-Min Hyun ◽  
Alan Wortman ◽  
David Powers
Keyword(s):  
Chemical Synthesis ◽  
Aerobic Oxidation ◽  
Substrate Oxidation ◽  
Oxidation Catalysis ◽  
Hypervalent Iodine ◽  
Oxidation Reactions ◽  
Broad Array ◽  
Oxidation Chemistry ◽  
Reactive Oxidants

<p>Hypervalent iodine(V) reagents, such as Dess-Martin periodinane (DMP) and 2-iodoxybenzoic acid (IBX), are broadly useful oxidants in chemical synthesis. Development of strategies to access these reagents from O2 would immediately enable use of O2 as a terminal oxidant in a broad array of substrate oxidation reactions. Recently we disclosed the aerobic synthesis of I(III) reagents by intercepting reactive oxidants generated during aldehyde autoxidation. Here, we couple aerobic oxidation of iodobenzenes with disproportionation of the initially generated I(III) compounds to generate I(V) reagents. The aerobically generated I(V) reagents exhibit substrate oxidation chemistry analogous to that of DMP. Further, the developed aerobic generation of I(V) has enabled the first application of I(V) intermediates in aerobic oxidation catalysis.</p>

Regioselective C3-H Trifluoromethylation of 2H-Indazole Under Transition-Metal-Free Photoredox Catalysis

2019 ◽  
Author(s):  
Arumugavel Murugan ◽  
Venkata Nagarjuna Babu ◽  
Nagaraj Sabarinathan ◽  
Sharada Duddu. S
Keyword(s):  
Transition Metal ◽  
Visible Light ◽  
Practical Approach ◽  
Hypervalent Iodine ◽  
Radical Mechanism ◽  
Photoredox Catalysis ◽  
Metal Free

Here we report a visible-light-promoted metal-free regioselective C3-H trifluoromehtylation reaction that proceeds via radical mechanism and which supported by control experiments. The combination of photoredox catalysis and hypervalent iodine reagent provides a practical approach for the present trifluoromethylation reaction and synthesis of a library of trifluoromethylated indazoles.

Electrochemical Vicinal Difluorination of Alkenes: Sustainable, Scalable, and Amenable to Electron-rich Substrates

2019 ◽  
Author(s):  
Sayad Doobary ◽  
Alexi Sedikides ◽  
Henry caldora ◽  
Darren poole ◽  
Alastair Lennox
Keyword(s):  
Bioactive Compounds ◽  
Hypervalent Iodine ◽  
Electrochemical Generation ◽  
Oxidative Decomposition ◽  
Alkyl Groups ◽  
Rich Functionality

Fluorinated alkyl groups are important motifs in bioactive compounds, positively influencing pharmacokinetics, potency and F conformation. The oxidative difluorination of alkenes represents an H important strategy for their preparation, yet current methods are limited in their alkene-types and tolerance of electron-rich, readily oxidized functionalities, as well as in their scalability. Herein, we report a method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-rich functionality, giving products that are otherwise unattainable. Key to success is the electrochemical generation of a hypervalent iodine mediator (in the presence of nucleophilic fluoride and HFIP) using an ‘ex-cell’ approach, which avoids the oxidative decomposition of the substrate. The more sustainable conditions give good to excellent yields of product in up to decagram scales<br>

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