Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity.

ChemInform ◽  
2006 ◽  
Vol 37 (15) ◽  
Author(s):  
Naoyoshi Maezaki ◽  
Hiroaki Tominaga ◽  
Naoto Kojima ◽  
Minori Yanai ◽  
Daisuke Urabe ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Total Synthesis ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Total Synthesis of Murisolins and Evaluation of Tumor-Growth Inhibitory Activity

2005 ◽  
Vol 11 (21) ◽  
pp. 6237-6245 ◽  
Author(s):  
Naoyoshi Maezaki ◽  
Hiroaki Tominaga ◽  
Naoto Kojima ◽  
Minori Yanai ◽  
Daisuke Urabe ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Total Synthesis ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

Total Synthesis of Isoprekinamycin:  Structural Evidence for Enhanced Diazonium Ion Character and Growth Inhibitory Activity toward Cancer Cells

2007 ◽  
Vol 9 (15) ◽  
pp. 2915-2918 ◽  
Author(s):  
Wei Liu ◽  
Matthew Buck ◽  
Nan Chen ◽  
Muhong Shang ◽  
Nicholas J. Taylor ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cancer Cells ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Diazonium Ion

scholarly journals Tumor-growth Inhibitory Activity of the Terpene Compound Isolated from Buna-shimeji Mushroom

2006 ◽  
Vol 53 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Shigetoshi Mizutani ◽  
Takashi Kawai ◽  
Tatsuji Enoki ◽  
Hiroaki Sagawa ◽  
Kazuo Shimanaka ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Inhibitory Activity ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity

scholarly journals Synthesis of Novel Shikonin Derivatives and Pharmacological Effects of Cyclopropylacetylshikonin on Melanoma Cells

Molecules ◽  
2018 ◽  
Vol 23 (11) ◽  
pp. 2820 ◽  
Author(s):  
Christin Durchschein ◽  
Antje Hufner ◽  
Beate Rinner ◽  
Alexander Stallinger ◽  
Alexander Deutsch ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Lines ◽  
Melanoma Cell ◽  
Inhibitory Activity ◽  
Melanoma Cells ◽  
Dna Breaks ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Shikonin Derivatives ◽  
Melanoma Cell Lines

Despite much research in the last centuries, treatment of malignant melanoma is still challenging because of its mostly unnoticeable metastatic spreading and aggressive growth rate. Therefore, the discovery of novel drug leads is an important goal. In a previous study, we have isolated several shikonin derivatives from the roots of Onosma paniculata Bureau & Franchet (Boraginaceae) which evolved as promising anticancer candidates. β,β-Dimethylacrylshikonin (1) was the most cytotoxic derivative and exhibited strong tumor growth inhibitory activity, in particular, towards melanoma cells. In this study, we synthesized eighteen novel shikonin derivatives in order to obtain compounds which exhibit a higher cytotoxicity than 1. We investigated their cytotoxic potential against various melanoma cell lines and juvenile skin fibroblasts. The most active compound was (R)-1-(1,4-dihydro-5,8-dihydroxy-1,4-dioxonaphthalen-2-yl)-4-methylpent-3-enyl cyclopropylacetate (cyclopropylacetylshikonin) (6). It revealed significant stronger tumor growth inhibitory activity towards two melanoma cell lines derived from metastatic lesions (WM164 and MUG-Mel2). Further investigations have shown that 6 induced apoptosis caspase-dependently, increased the protein levels of cleaved PARP, and led to double-stranded DNA breaks as shown by phosphorylation of H2AX. Cell membrane damage and cell cycle arrest were not observed.

scholarly journals Enterohepatic recirculation of bioactive ginger phytochemicals is associated with enhanced tumor growth-inhibitory activity of ginger extract

2014 ◽  
Vol 35 (6) ◽  
pp. 1320-1329 ◽  
Author(s):  
Sushma R. Gundala ◽  
Rao Mukkavilli ◽  
Chunhua Yang ◽  
Pooja Yadav ◽  
Vibha Tandon ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Inhibitory Activity ◽  
Enterohepatic Recirculation ◽  
Ginger Extract ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity
Sign in / Sign up

Export Citation Format

Share Document