scholarly journals Carbon—Carbon Bond-Forming Enantioselective Synthesis of Chiral Organosilicon Compounds by Rhodium/Chiral Diene-Catalyzed Asymmetric 1,4-Addition Reaction.

ChemInform ◽  
2006 ◽  
Vol 37 (9) ◽  
Author(s):  
Ryo Shintani ◽  
Kazuhiro Okamoto ◽  
Tamio Hayashi
Keyword(s):  
Addition Reaction ◽  
Enantioselective Synthesis ◽  
Organosilicon Compounds ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Carbon Bond

Palladium-mediated cascade or multicomponent reactions: A new route to carbo- and heterocyclic compounds

2006 ◽  
Vol 78 (2) ◽  
pp. 231-239 ◽  
Author(s):  
Geneviève Balme ◽  
Didier Bouyssi ◽  
Nuno Monteiro
Keyword(s):  
Transition Metal ◽  
Intramolecular Cyclization ◽  
Heterocyclic Compounds ◽  
Multicomponent Reactions ◽  
Addition Reaction ◽  
Carbon Bond ◽  
Bond Forming ◽  
Carbon Nucleophiles ◽  
Carbon Carbon Bond

In recent years, new processes based on transition-metal-mediated intramolecular addition reaction of heteronucleophiles and stabilized carbon nucleophiles to unactivated alkenes and alkynes have been developed in our laboratory. In this article, we summarize a number of recent synthetic applications of these new processes. Emphasis is placed on the development of multicomponent reactions based on a Pd-mediated intramolecular cyclization coupled with a carbon-carbon bond-forming reaction. Applications of this methodology to the synthesis of natural lignans are also reported.

Nickel-Catalyzed Electronically-Reversed Enantioselective Hydrocarbofunctionalizations of Acrylamides

Synlett ◽  
2021 ◽  
Author(s):  
Lou Shi ◽  
Wei Shu
Keyword(s):  
Nickel Catalyst ◽  
Functional Group ◽  
Optically Active ◽  
Forming Process ◽  
Carbon Bond ◽  
Bond Forming ◽  
Synthetic Strategy ◽  
Carbon Carbon Bond ◽  
Wide Range ◽  
Simple Protocol

Asymmetric hydrocarbofunctionalizations of alkenes has emerged as an efficient synthetic strategy for accessing optically active molecules via carbon-carbon bond-forming process from readily available alkenes and carbo-electrophiles. Herein, we present a summary of the efforts from our group to control the regio- and enantioselectivity of hydrocarbofunctionalizations of electron-deficient alkenes with a nickel catalyst and chiral bisoxazolidine ligand. The reaction undergoes electron-reversed hydrocarbofunctionalizations acrylamides with excellent enantioselectivity. This operationally simple protocol enables the asymmetric hydroalkylation, hydrobenzylation and hydropropargylation of acrylamides. This reaction is useful for preparing a wide range of α-branched chiral amides with broad functional group tolerance.

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