Regioselective Synthesis of Quinolone Antibacterials via Borate Complex of Quinolone Carboxylic Acid.

ChemInform ◽  
2006 ◽  
Vol 37 (6) ◽  
Author(s):  
Majid M. Heravi ◽  
Zeinab S. Jaddi ◽  
Hossein A. Oskooie ◽  
Shahnaz Khaleghi ◽  
Mitra Ghassemzadeh
Keyword(s):  
Carboxylic Acid ◽  
Regioselective Synthesis ◽  
Borate Complex

Regioselective Synthesis of Quinolone Antibacterials via Borate Complex of Quinolone Carboxylic Acid

2005 ◽  
Vol 2005 (9) ◽  
pp. 578-579 ◽  
Author(s):  
Majid M. Heravi ◽  
Zeinab S. Jaddi ◽  
Hossein A. Oskooie ◽  
Shahnaz Khaleghi ◽  
Mitra Ghassemzadeh
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Regioselective Synthesis ◽  
Borate Complex ◽  
Borate Complexes ◽  
High Yields

1-substituted 7-chloro-6-fluoro-4-oxo-1,2-dihydroquinoline-3-carboxylic acids were converted to borate complexes. These compounds were treated with piperazine in presence of triethylamine to afford ciprofloxacin and norfloxacin in high yields.

scholarly journals Practical and Regioselective Synthesis of C4-Alkylated Pyridines

2021 ◽  
Author(s):  
jin choi ◽  
Gabriele Laudadio ◽  
Edouard Godineau ◽  
Phil Baran
Keyword(s):  
Carboxylic Acid ◽  
Late Stage ◽  
Building Blocks ◽  
Regioselective Synthesis ◽  
Heterocyclic Chemistry ◽  
Blocking Group ◽  
Functionalized Materials

The direct position-selective C–4 alkylation of pyridines has been a longstanding challenge in heterocyclic chemistry, particularly from pyridine itself. Historically this has been addressed using pre-functionalized materials to avoid overalkylation and mixtures of regioisomers. This study reports the invention of a simple maleate-derived blocking group for pyridines that enables exquisite control for Minisci-type decarboxylative alkylation at C–4 that allows for inexpensive access to these valuable building blocks. The method is employed on a variety of different pyridines and carboxylic acid alkyl donors, is operationally simple, scalable, and is applied to access known structures in a rapid and inexpensive fashion. Finally, this work points to an interesting strategic departure for the use of Minisci chemistry at the earliest possible stage (native pyridine) rather than current dogma that almost exclusively employs Minisci as a late-stage functionalization technique.

Regioselective synthesis of ortho-iodobiphenylboronic acid derivatives: a superior catalyst for carboxylic acid activation

2020 ◽  
Vol 44 (9) ◽  
pp. 3612-3623 ◽  
Author(s):  
Raed M. Al-Zoubi ◽  
Walid K. Al-Jammal ◽  
Robert McDonald
Keyword(s):  
Carboxylic Acid ◽  
Regioselective Synthesis ◽  
Acid Activation ◽  
Microbial Activities

Efficient and versatile synthesis of ortho-iodobiphenylboronic acids with remarkable catalytic and microbial activities.

Copper-catalyzed regioselective synthesis of furan via tandem cycloaddition of ketone with an unsaturated carboxylic acid under air

2015 ◽  
Vol 13 (1) ◽  
pp. 309-314 ◽  
Author(s):  
Monoranjan Ghosh ◽  
Subhajit Mishra ◽  
Kamarul Monir ◽  
Alakananda Hajra
Keyword(s):  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Ambient Air ◽  
Regioselective Synthesis ◽  
Unsaturated Carboxylic Acid ◽  
Unsaturated Carboxylic Acids

A catalytic decarboxylative annulation has been developed for the regioselective synthesis of furans by the cycloaddition of ketones with α,β-unsaturated carboxylic acids in ambient air.

Regioselective Synthesis of Fused Furans by Decarboxylative Annulation of α,β‐Alkenyl Carboxylic Acid with Cyclic Ketone: Synthesis of Di‐Heteroaryl Derivatives

2019 ◽  
Vol 131 (32) ◽  
pp. 11155-11159
Author(s):  
Soumitra Agasti ◽  
Tapas Pal ◽  
Tapas Kumar Achar ◽  
Siddhartha Maiti ◽  
Debasis Pal ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Regioselective Synthesis ◽  
Cyclic Ketone
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