N-Functionalization of Uracil Derivatives: Synthesis of Chiral 2-(3-Methyl-5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)alkanoic Acids and Their Methyl Esters.

ChemInform ◽  
2005 ◽  
Vol 36 (44) ◽  
Author(s):  
Andrzej Gondela ◽  
Krzysztof Walczak
Keyword(s):  
Methyl Esters ◽  
Uracil Derivatives ◽  
Alkanoic Acids

Déplacements homolytiques intramoléculaires. 4. Thermolyse du perpentène-4 oate de tert-butyle dans les acides et leurs derivés: préparation de γ-butyrolactones substituées en 4 par un groupe comportant une fonction ester, acide ou nitrile

1985 ◽  
Vol 63 (9) ◽  
pp. 2522-2528 ◽  
Author(s):  
A. Kharrat ◽  
C. Gardrat ◽  
B. Maillard
Keyword(s):  
Carboxylic Acids ◽  
Methyl Esters ◽  
Homolytic Reaction ◽  
Alkanoic Acids

The thermolysis of tert-butylperpent-4-enoate in various solvents ZH (carboxylic acids, anhydrides, methyl esters, nitriles) led to γ-butyrolactones 4-substituted by the group ZCH2 with good yields. The acidic treatment of the lactones 4 and 6 derived from non-functionalized alkanoic acids and methyl esters gave respectively the isomerized lactones 5 and 7, increasing the synthetic interest of the studied homolytic reaction.

Antifungal properties of 2-alkynoic acids and their methyl esters

1978 ◽  
Vol 24 (5) ◽  
pp. 593-597 ◽  
Author(s):  
Herman Gershon ◽  
Larry Shanks
Keyword(s):  
Candida Albicans ◽  
Chain Length ◽  
Inverse Relationship ◽  
Methyl Esters ◽  
Trichoderma Viride ◽  
Trichophyton Mentagrophytes ◽  
Weight Basis ◽  
Alkanoic Acids ◽  
Mucor Mucedo ◽  
Partition Behavior

Thirteen 2-alkynoic acids and their methyl esters (C3–C12, C14, C16, and C18) were tested against Aspergillus niger, Trichoderma viride, and Myrothecium verrucaria in Sabouraud dextrose agar at pH 4.0 and 5.6. Toxicity to Candida albicans, Trichophyton mentagrophytes, and Mucor mucedo was determined in the same medium at pH 5.6 and 7.0 in the absence and presence of 10% beef serum. The fungitoxicity of the acids was influenced by chain length, pH of the medium, and absence or presence of adsorbents. The toxicity of the esters was influenced primarily by chain length and to a lesser extent by the pH of the medium and the presence of beef serum. The order of activity of the 2-alkynoic acids is C10 = C11 = C12 > C14 = C16 > C9 > C8 > C7.When compared with other fatty acid analogs, the order of fungitoxicity on a weight basis is 2-alkynoic acids > 2-alkenoic acids > alkanoic acids > 2-bromoalkanoic acids > 2-fluoroalkanoic acids. There is an inverse relationship between chain length and pKa of the acids, suggesting that partition behavior is a fundamental determinant of fungitoxicity along with the effect of adsorbents.

ChemInform Abstract: Synthesis and Antileishmanial Activity of 2,3-Disubstituted Chromon-6- yl-alkanoic Acids and Their Methyl Esters.

ChemInform ◽  
2010 ◽  
Vol 26 (52) ◽  
pp. no-no
Author(s):  
S. P. BHATTI ◽  
C. P. GARG ◽  
R. P. KAPOOR ◽  
S. SHARMA ◽  
A. KAPIL
Keyword(s):  
Methyl Esters ◽  
Antileishmanial Activity ◽  
Alkanoic Acids

Thermoacoustic properties of methyl esters ofn -alkanoic acids

1995 ◽  
Vol 72 (6) ◽  
pp. 687-691 ◽  
Author(s):  
Sandya Cole ◽  
J. V. Rao ◽  
P. Venkatacharyulu
Keyword(s):  
Methyl Esters ◽  
Alkanoic Acids ◽  
Thermoacoustic Properties

Cuticular waxes from the leaves and fruit capsules of eight Papaveraceae species

1996 ◽  
Vol 74 (3) ◽  
pp. 419-430 ◽  
Author(s):  
Reinhard Jetter ◽  
Markus Riederer
Keyword(s):  
Methyl Esters ◽  
Cuticular Wax ◽  
Biosynthetic Pathways ◽  
Cuticular Waxes ◽  
Alkanoic Acid ◽  
Eschscholtzia Californica ◽  
Acid Methyl ◽  
Isomer Composition ◽  
Alkanoic Acids

Cuticular waxes from leaves and fruit capsules of Papaver alpinum sensu Markgr., P. bracteatum Lindl., P. dubium L., P. nudicaule L., P. orientale L., P. rhoeas L., P. somniferum L., and Eschscholtzia californica Cham. were investigated. They consisted of n-alkanes (< 19%), alk-1-ylesters (< 18%), alk-2-ylesters (< 6%), alkanals (< 19%), secondary alkanols (21–71%, mainly nonacosan-10-ol), triglycerides (< 6%), primary alkanols (2–33%), alkanediols (2–23%, mainly isomeric nonacosanediols), alkanoic acids (< 8%), and alkaloids (< 12%). In addition, minor amounts of iso- and anteiso-alkanes, alkanoic acid methyl esters, esters of alkan-10-ols, benzyl- and phenyl-ethylalcohol, triterpenols and phytosterols, ketols, and ketones were detectable. The isomer composition of the secondary alkanols and their alkanediol, ketol, and ketone derivatives is used to deduce the probable sequence of steps in the respective biosynthetic pathways. Keywords: Papaver, Eschscholtzia, Papaveraceae, cuticular wax, secondary alkanols, biosynthesis.

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