Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines.

ChemInform ◽  
2005 ◽  
Vol 36 (33) ◽  
Author(s):  
Dana Hockova ◽  
Milena Masojidkova ◽  
Antonin Holy
Keyword(s):  
Cross Coupling ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Sonogashira Cross-Coupling in the Synthesis of Acyclic Nucleoside Phosphonates: Preparation of 6-[(Phosphonomethoxy)alkynyl]- and 6-[(Phosphonomethoxy)alkyl]pyrimidines

2005 ◽  
Vol 70 (2) ◽  
pp. 247-258 ◽  
Author(s):  
Dana Hocková ◽  
Milena Masojídková ◽  
Antonín Holý
Keyword(s):  
Biological Activity ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cross Coupling Reaction ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Several 6-[(phosphonomethoxy)alkyl]pyrimidines and 6-[(phosphonomethoxy)alkynyl]pyrimidines were prepared as saturated and unsaturated carba-analogues of antivirally active 2,4-diamino-6-[2-(phosphonomethoxy)ethoxy]pyrimidine. As the key step of their synthesis the Sonogashira cross-coupling reaction was successfully applied. The replacement of the C-O moiety by the C-C bond resulted in the loss of biological activity.

The efficient synthesis of 2-arylpyrimidine acyclic nucleoside phosphonates using Liebeskind–Srogl cross-coupling reaction

Tetrahedron ◽  
2011 ◽  
Vol 67 (38) ◽  
pp. 7379-7385 ◽  
Author(s):  
Petra Břehová ◽  
Michal Česnek ◽  
Martin Dračínský ◽  
Antonín Holý ◽  
Zlatko Janeba
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Efficient Synthesis ◽  
Cross Coupling Reaction ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside

Acyclic nucleoside phosphonates and human telomerase inhibition

2005 ◽  
Author(s):  
Miroslav Hájek ◽  
Naděžda Matulová ◽  
Ivan Votruba ◽  
Antonín Holý ◽  
Eva Tloušťová
Keyword(s):  
Telomerase Inhibition ◽  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside ◽  
Human Telomerase

Tyrosine-based prodrugs of acyclic nucleoside phosphonates

2014 ◽  
Author(s):  
Tomáš Tichý ◽  
Karel Pomeisl ◽  
Marcela Krečmerová ◽  
Charles E. McKenna
Keyword(s):  
Acyclic Nucleoside Phosphonates ◽  
Acyclic Nucleoside
Sign in / Sign up

Export Citation Format

Share Document