Studies on Pyrazine Derivatives. Part 38. Synthesis, Reactions, and Tuberculostatic Activity of Pyrazinyl-Substituted Derivatives of Hydrazinocarbodithioic Acid.

ChemInform ◽  
2005 ◽  
Vol 36 (23) ◽  
Author(s):  
H. Foks ◽  
I. Trapkowska ◽  
M. Janowiec ◽  
Z. Zwolska ◽  
E. Augustynowicz-Kopec
Keyword(s):  
Tuberculostatic Activity ◽  
Synthesis Reactions ◽  
Derivatives Of

scholarly journals Synthesis of Optically Active Bicyclic Derivatives of Nitroimidazoles

Compounds ◽  
2021 ◽  
Vol 1 (3) ◽  
pp. 145-153
Author(s):  
Justyna Żwawiak ◽  
Lucjusz Zaprutko
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Biological Activity ◽  
Optically Active ◽  
Tuberculostatic Activity ◽  
Wide Range ◽  
Derivatives Of

Nitroimidazoles are characterized by a wide range of biological activity and many of them are used as therapeutics. Moreover, some bicyclic nitroimidazooxazoles show considerable potency against Mycobacterium tuberculosis. Some authors noticed that in the case of chiral derivatives of nitroimidazodihydrooxazoles, the (R) form shows a greater tuberculostatic activity than the (S) enantiomer. This work describes the procurement of new 12 enantiomeric bicyclic derivatives of nitroimidazole.

Review on Synthesis, Reactions and Biological Properties of Seven Member Heterocyclic Compounds: Azepine, Azepane, Azepinone

2021 ◽  
Vol 25 ◽  
Author(s):  
Manvinder Kaur ◽  
Sonali Garg ◽  
Dharambeer S. Malhi ◽  
Harvinder S. Sohal
Keyword(s):  
Microwave Irradiation ◽  
Heterocyclic Compounds ◽  
Ring Expansion ◽  
Biological Properties ◽  
Synthesis Reaction ◽  
Therapeutic Implications ◽  
Synthesis Reactions ◽  
Derivatives Of

Abstract: Seven membered heterocyclic Azepine and its derivatives have great pharmacological and therapeutic implications. In this review, the literature of the last fifty years has been exploited for the synthesis, reaction, and biological properties of these seven-member heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five or six-membered compounds using various methods such as thermally, photo-chemically, and microwave irradiation. The systematically designed schemes involve the synthesis of different derivatives of azepine, azepinone, azepane, etc. using similar moieties by the different researchers. However, there is much work yet to be done in the biological section, as it is not explored and reported in the literature; therefore, N-containing seven-membered heterocycles still have much scope for the researchers.

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