Antiproliferative Activity and Mechanism of Action of Fatty Acid Derivatives of Gemcitabine in Leukemia and Solid Tumor Cell Lines and in Human Xenografts

ChemInform ◽  
2005 ◽  
Vol 36 (10) ◽  
Author(s):  
A. M. Bergman ◽  
et al. et al.
Keyword(s):  
Fatty Acid ◽  
Tumor Cell ◽  
Cell Lines ◽  
Mechanism Of Action ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Fatty Acid Derivatives ◽  
Derivatives Of

Antiproliterative Activity and Mechanism of Action of Fatty Acid Derivatives of Arabinosylcytosine (ara-C) in Leukemia and Solid Tumor Cell Lines

ChemInform ◽  
2005 ◽  
Vol 36 (12) ◽  
Author(s):  
A. M. Bergmann ◽  
C. M. Kuiper ◽  
F. Myhren ◽  
M. L. Sandvold ◽  
H. R. Hendriks ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Tumor Cell ◽  
Cell Lines ◽  
Mechanism Of Action ◽  
Solid Tumor ◽  
Tumor Cell Lines ◽  
Fatty Acid Derivatives ◽  
Derivatives Of

Antiproliferative activity of novel benzo[b][1,6]naphthyridines in human solid tumor cell lines

2010 ◽  
Vol 20 (5) ◽  
pp. 1504-1506 ◽  
Author(s):  
Simonas Rudys ◽  
Carla Ríos-Luci ◽  
Eduardo Pérez-Roth ◽  
Inga Cikotiene ◽  
José M. Padrón
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Human Solid Tumor

scholarly journals Lipophilic Salirasib analogs with enhanced antiproliferative activity against human solid tumor cell lines

2021 ◽  
Author(s):  
Exequiel O. J. Porta ◽  
María Sol Ballari ◽  
José M. Padrón ◽  
Guillermo R. Labadie
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Cancer Cell ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
In Silico ◽  
Tumor Cell Lines ◽  
Human Solid Tumor ◽  
Physicochemical Features ◽  
Sar Analysis

Aim: We proposed to determine the antiproliferative activity of a series of synthetic salirasib analogs, presenting or not a 1,2,3-triazole linker, against five different cancer cell lines. Results: Bioassay, cheminformatic, and in silico ADME-Tox allowed the identification of new potent analogs. SAR analysis allowed the identification of structural and physicochemical features that benefit the antiproliferative activity. Conclusion: Isoprenyl R chains with three or more isoprene units, or long aliphatic R chains are the preferred ones within the active compounds. Likewise, we have identified three compounds with better activity profiles than salirasib against all the cell lines tested.

Antiproliferative activity of 2-alkyl-4-halopiperidines and 2-alkyl-4-halo-1,2,5,6-tetrahydropyridines in solid tumor cell lines

2007 ◽  
Vol 17 (10) ◽  
pp. 2681-2684 ◽  
Author(s):  
Leticia G. León ◽  
Rubén M. Carballo ◽  
María C. Vega-Hernández ◽  
Víctor S. Martín ◽  
Juan I. Padrón ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines

Norcantharidin analogues — Synthesis and evaluation of growth inhibition in a panel of selected tumor-cell lines

2007 ◽  
Vol 85 (11) ◽  
pp. 938-944 ◽  
Author(s):  
Liping Deng ◽  
Li Shen ◽  
Jing Zhang ◽  
Bo Yang ◽  
Qiaojun He ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Growth Inhibition ◽  
Cell Lines ◽  
Antiproliferative Activity ◽  
Aromatic Amines ◽  
Cycloaddition Reaction ◽  
Dipolar Cycloaddition ◽  
Tumor Cell Lines ◽  
Derivatives Of

A series of norcantharidin (NCTD) analogues have been synthesized by [3+2]1,3-dipolar cycloaddition reaction of norcantharidin derivatives of substituted aromatic amines with four nitrile oximes. All analogues have been screened for their antiproliferative activity in vitro against a panel of tumor cell lines: KB, SGC-7901, HL60, Bel-7402, HO-8910, and ECA109, producing IC50 values from 0.36 µmol/L to >100 µmol/L. Compound 9d showed potency for the treatment of hepatoma, with IC50 value to Bel-7402 cell line comparable to that of norcantharidin.Key words: norcantharidin analogues, isoxazoline, growth inhibition.

Synthesis and biological evaluation of novel derivatives of gambogenic acid as anticancer agents

MedChemComm ◽  
2015 ◽  
Vol 6 (2) ◽  
pp. 334-338 ◽  
Author(s):  
Peng Huang ◽  
Zhong Hu ◽  
Liqin He ◽  
Xiaoshan Wang ◽  
Yaxian Wu
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Anticancer Agents ◽  
Antiproliferative Activity ◽  
Biological Evaluation ◽  
Tumor Cell Lines ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of

A series of novel derivatives of gambogenic acid (GNA) were synthesized and evaluated for their in vitro antiproliferative activity against four kinds of tumor cell lines. These compounds displayed potent antiproliferative activity. In particular, compound 3f exhibited superior antiproliferative activity against these tumor cell lines than GNA.

ChemInform Abstract: Antiproliferative Activity of Novel Benzo[b][1,6]naphthyridines in Human Solid Tumor Cell Lines.

ChemInform ◽  
2010 ◽  
Vol 41 (30) ◽  
pp. no-no
Author(s):  
Simonas Rudys ◽  
Carla Rios-Luci ◽  
Eduardo Perez-Roth ◽  
Inga Cikotiene ◽  
Jose M. Padron
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Solid Tumor ◽  
Antiproliferative Activity ◽  
Tumor Cell Lines ◽  
Human Solid Tumor
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