Catalytic Antibodies: Hapten Design Strategies and Screening Methods

ChemInform ◽  
2005 ◽  
Vol 36 (6) ◽  
Author(s):  
Yang Xu ◽  
Noboru Yamamoto ◽  
Kim D. Janda
Keyword(s):  
Catalytic Antibodies ◽  
Screening Methods ◽  
Design Strategies ◽  
Hapten Design

Catalytic antibodies: hapten design strategies and screening methods

2004 ◽  
Vol 12 (20) ◽  
pp. 5247-5268 ◽  
Author(s):  
Yang Xu ◽  
Noboru Yamamoto ◽  
Kim D. Janda
Keyword(s):  
Catalytic Antibodies ◽  
Screening Methods ◽  
Design Strategies ◽  
Hapten Design

Catalytic Antibodies for Complex Reactions Hapten Design and the Importance of Screening for Catalysis in the Generation of Catalytic Antibodies for the NDA/CN Reaction

2000 ◽  
Vol 83 (1-3) ◽  
pp. 195-208 ◽  
Author(s):  
Binodh S. Desilva ◽  
Gyorgy Orosz ◽  
Kamal L. Egodage ◽  
Robert G. Carlson ◽  
Richard L. Schowen ◽  
...  
Keyword(s):  
Catalytic Antibodies ◽  
Hapten Design

scholarly journals Augmenting the efficacy of anti-cocaine catalytic antibodies through chimeric hapten design and combinatorial vaccination

2017 ◽  
Vol 27 (16) ◽  
pp. 3666-3668 ◽  
Author(s):  
Cody J. Wenthur ◽  
Xiaoqing Cai ◽  
Beverly A. Ellis ◽  
Kim D. Janda
Keyword(s):  
Catalytic Antibodies ◽  
Hapten Design

Data Screening Methods – Application to Differential Diagnosis in Pancreatic Pathology from Radiological Signs

1978 ◽  
Vol 17 (01) ◽  
pp. 36-40 ◽  
Author(s):  
J.-P. Durbec ◽  
Jaqueline Cornée ◽  
P. Berthezene
Keyword(s):  
Differential Diagnosis ◽  
Mutual Information ◽  
Data Processing ◽  
Screening Methods ◽  
Automatic Data ◽  
Chronic Calcifying Pancreatitis ◽  
Number Of Patients ◽  
Calcifying Pancreatitis ◽  
Pancreatic Pathology ◽  
Data Screening

The practice of systematic examinations in hospitals and the increasing development of automatic data processing permits the storing of a great deal of information about a large number of patients belonging to different diagnosis groups.To predict or to characterize these diagnosis groups some descriptors are particularly useful, others carry no information. Data screening based on the properties of mutual information and on the log cross products ratios in contingency tables is developed. The most useful descriptors are selected. For each one the characterized groups are specified.This approach has been performed on a set of binary (presence—absence) radiological variables. Four diagnoses groups are concerned: cancer of pancreas, chronic calcifying pancreatitis, non-calcifying pancreatitis and probable pancreatitis. Only twenty of the three hundred and forty initial radiological variables are selected. The presence of each corresponding sign is associated with one or more diagnosis groups.

Rapid Screening Methods for Bleeding Disorders. A Three Year Survey

1964 ◽  
Vol 11 (02) ◽  
pp. 506-512 ◽  
Author(s):  
V. A Lovric ◽  
J Margolis
Keyword(s):  
Laboratory Tests ◽  
Capillary Blood ◽  
Screening Tests ◽  
Rapid Screening ◽  
Screening Methods ◽  
Bleeding Disorders ◽  
Routine Laboratory ◽  
Clotting Time ◽  
Kaolin Clotting Time ◽  
In Infants And Children

SummaryAn adaptation of “kaolin clotting time” and prothrombin time for use on haemolysed capillary blood provided simple and sensitive screening tests suitable for use in infants and children. A survey of three year’s experience shows that these are reliable routine laboratory tests for detection of latent coagulation disorders.

Proposal for Objective Evaluation of the Performance of Various Functional APC-resistance Tests in Genotyped Patients

1997 ◽  
Vol 78 (05) ◽  
pp. 1360-1365 ◽  
Author(s):  
G Freyburger ◽  
S Javorschi ◽  
S Labrouche ◽  
P Bernard
Keyword(s):  
Protein S ◽  
Objective Evaluation ◽  
Original Method ◽  
Screening Methods ◽  
Factor Xii ◽  
Factor V ◽  
Likelihood Ratios ◽  
Modified Method ◽  
Apc Resistance ◽  
Two Parameters

SummaryThe aim of the present study was to evaluate the relative performance of five screening methods for APC resistance caused by the factor V:Q506 mutation: the original method Coatest® APC™ Resistance Chromogenix, a modified method using the same reagents but a predilution 1+4 of the plasma in a factor V deficient plasma from Stago (Stago deficient V) or from Chromogenix (V-DEF Plasma), the Coatest® APC™ Resistance V (Chromogenix), and Accelerimat™ from bioMérieux. Normalization was done against a pool of normal plasmas for the methods from Chromogenix. The study included 350 subjects, 219 were genotyped (174 FV:R506R, 42 FV:Q506R, 3 FV:Q506Q) and most of them were assessed by more than one method. Uncertainty in predicting the FV genotype was evaluated by statistical analysis, which provided a way to quantitate the performance of the different diagnostic approaches. Performance of each test was evaluated by its sensitivity, specificity, R.O.C. curves, positive and negative likelihood ratios (LR), and the overall performance was determined by two parameters derived from the LR curves : the maximum LR value obtained at the crossover of the two curves, and the distance between the two curves for LR = 10. Coatest® APC™ Resistance V and Accelerimat™ were proven to be the methods most able to discriminate for factor V:Q506, while normalization was not shown to improve the screening performance. The original method from Chromogenix was confirmed to undergo many influences (factor XII, PAI-1, thrombin- antithrombin complexes, antithrombin III, hematocrit). Although a very good improvement was provided by the newest methods, they were shown to be influenced by protein S and/or factor V levels in the sample plasma.

Sign in / Sign up

Export Citation Format

Share Document