Silica-Supported Sodium Hydrogen Sulfate and Amberlyst-15: Two Efficient Heterogeneous Catalysts for Single-Step Synthesis of 4(3H)-Quinazolinones from Anthranilic Acid, Orthoesters, and Amines under Solvent-Free Conditions.

ChemInform ◽  
2005 ◽  
Vol 36 (3) ◽  
Author(s):  
Biswanath Das ◽  
Joydeep Banerjee
Keyword(s):  
Anthranilic Acid ◽  
Heterogeneous Catalysts ◽  
Single Step ◽  
Solvent Free ◽  
Hydrogen Sulfate ◽  
Amberlyst 15 ◽  
Sodium Hydrogen ◽  
Solvent Free Conditions

Silica Gel Supported Sodium Hydrogen Sulfate as an Efficient and Reusable Heterogeneous Catalyst for the Synthesis of Imines in Solvent-free Conditions under Microwave Irradiation

2005 ◽  
Vol 2005 (5) ◽  
pp. 299-303 ◽  
Author(s):  
Mannathusamy Gopalakrishnan ◽  
Purushothaman Sureshkumar ◽  
Vijayakumar Kanagarajan ◽  
Jeyaraman Thanusu ◽  
Ramalingam Govindaraju
Keyword(s):  
Microwave Irradiation ◽  
Heterogeneous Catalyst ◽  
Silica Gel ◽  
Diethyl Ether ◽  
Carbonyl Compounds ◽  
Solvent Free ◽  
Hydrogen Sulfate ◽  
Sodium Hydrogen ◽  
Solvent Free Conditions

This synthesis of imines has been carried out efficiently by the condensation of carbonyl compounds with amines in the presence of silica gel supported sodium hydrogen sulfate (NaHSO4.SiO2) as a heterogeneous catalyst under microwave irradiation in solvent-free conditions. NaHSO4.SiO2 can be recovered and re-used up to ten times by simple washing with diethyl ether after each use and activated in an oven at 120 °C for 1 h, thus rendering the process more economical.

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