Synthesis and Antiviral Activity of P1′ Arylsulfonamide Azacyclic Urea HIV Protease Inhibitors.

ChemInform ◽  
2004 ◽  
Vol 35 (49) ◽  
Author(s):  
Peggy P. Huang ◽  
John T. Randolph ◽  
Larry L. Klein ◽  
Sudthida Vasavanonda ◽  
Tatyana Dekhtyar ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport

1995 ◽  
Vol 117 (45) ◽  
pp. 11113-11123 ◽  
Author(s):  
Amos B Smith ◽  
Ralph Hirschmann ◽  
Alexander Pasternak ◽  
Mark C. Guzman ◽  
Akihisa Yokoyama ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Design Synthesis

Synthesis, antiviral activity, and bioavailability studies of γ-lactam derived HIV protease inhibitors

1994 ◽  
Vol 2 (9) ◽  
pp. 859-879 ◽  
Author(s):  
Randall W. Hungate ◽  
Jenny L. Chen ◽  
Ken E. Starbuck ◽  
Joseph P. Vacca ◽  
Stacey L. McDaniel ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

Increased antiviral activity of HIV protease inhibitors of the difluorostatone type bearing (R)-valinol derivatives as novel c-termini

1994 ◽  
Vol 4 (10) ◽  
pp. 1213-1218 ◽  
Author(s):  
V. Van Dorsselaer ◽  
D. Schirlin ◽  
C. Tarnus ◽  
D.L. Taylor ◽  
A.S. Tyms ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

Synthesis and antiviral activity of P1′ arylsulfonamide azacyclic urea HIV protease inhibitors

2004 ◽  
Vol 14 (15) ◽  
pp. 4075-4078 ◽  
Author(s):  
Peggy P Huang ◽  
John T Randolph ◽  
Larry L Klein ◽  
Sudthida Vasavanonda ◽  
Tatyana Dekhtyar ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

ChemInform Abstract: Pyrrolinone-Based HIV Protease Inhibitors. Design, Synthesis, and Antiviral Activity: Evidence for Improved Transport.

ChemInform ◽  
2010 ◽  
Vol 27 (13) ◽  
pp. no-no
Author(s):  
A. B. III SMITH ◽  
R. HIRSCHMANN ◽  
A. PASTERNAK ◽  
M. C. GUZMAN ◽  
A. YOKOYAMA ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors ◽  
Design Synthesis

Synthesis, antiviral activity and pharmacokinetics of P1/P1′ substituted 3-aminoindazole cyclic urea HIV protease inhibitors

2003 ◽  
Vol 13 (4) ◽  
pp. 605-608 ◽  
Author(s):  
Robert F Kaltenbach ◽  
Mona Patel ◽  
Robert E Waltermire ◽  
Gregory D Harris ◽  
Benjamin R.P Stone ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

Design of HIV protease inhibitors with effective antiviral activity: Use of allophenylnorstatine as a transition-state mimic

Peptides 1992 ◽  
1993 ◽  
pp. 805-807
Author(s):  
Yoshiaki Kiso ◽  
Tsutomu Mimoto ◽  
Junya Imai ◽  
Sumitsugu Kisanuki ◽  
Naoko Hattori ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Transition State ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

Increased antiviral activity of cyclic urea HIV protease inhibitors by modifying the P1/P1′ substituents

1999 ◽  
Vol 9 (15) ◽  
pp. 2259-2262 ◽  
Author(s):  
Robert F. Kaltenbach ◽  
Ronald M. Klabe ◽  
Beverly C. Cordova ◽  
Steven P. Seitz
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors

scholarly journals Antiviral activity of the dihydropyrone PNU-140690, a new nonpeptidic human immunodeficiency virus protease inhibitor.

1997 ◽  
Vol 41 (5) ◽  
pp. 1058-1063 ◽  
Author(s):  
S M Poppe ◽  
D E Slade ◽  
K T Chong ◽  
R R Hinshaw ◽  
P J Pagano ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Pharmacokinetic Studies ◽  
Hiv Protease Inhibitors ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Hiv 1

PNU-140690 is a member of a new class of nonpeptidic human immunodeficiency virus (HIV) protease inhibitors (sulfonamide-containing 5,6-dihydro-4-hydroxy-2-pyrones) discovered by structure-based design. PNU-140690 has excellent potency against a variety of HIV type 1 (HIV-1) laboratory strains and clinical isolates, including those resistant to the reverse transcriptase inhibitors zidovudine or delavirdine. When combined with either zidovudine or delavirdine, PNU-140690 contributes to synergistic antiviral activity. PNU-140690 is also highly active against HIV-1 variants resistant to peptidomimetic protease inhibitors, underscoring the structural distinctions between PNU-140690 and substrate analog protease inhibitors. PNU-140690 retains good antiviral activity in vitro in the presence of human plasma proteins, and preclinical pharmacokinetic studies revealed good oral bioavailability. Accordingly, PNU-140690 is a candidate for clinical evaluation.

ChemInform Abstract: Increased Antiviral Activity of Cyclic Urea HIV Protease Inhibitors by Modifying the P1/P1′ Substituents.

ChemInform ◽  
2010 ◽  
Vol 30 (46) ◽  
pp. no-no
Author(s):  
Robert F. Kaltenbach III ◽  
Ronald M. Klabe ◽  
Beverly C. Cordova ◽  
Steven P. Seitz
Keyword(s):  
Antiviral Activity ◽  
Protease Inhibitors ◽  
Hiv Protease ◽  
Hiv Protease Inhibitors
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