Design, Synthesis, Conformational Analysis and Application of Azabicycloalkane Amino Acids as Constrained Dipeptide Mimics

ChemInform ◽  
2004 ◽  
Vol 35 (40) ◽  
Author(s):  
Laura Belvisi ◽  
Lino Colombo ◽  
Leonardo Manzoni ◽  
Donatella Potenza ◽  
Carlo Scolastico
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Design Synthesis

Design, Synthesis, Conformational Analysis and Application of Azabicyclo­alkane Amino Acids as Constrained Dipeptide Mimics

Synlett ◽  
2004 ◽  
pp. 1449-1471 ◽  
Author(s):  
Carlo Scolastico ◽  
Laura Belvisi ◽  
Lino Colombo ◽  
Leonardo Manzoni ◽  
Donatella Potenza
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Design Synthesis

ChemInform Abstract: Arabinose-Derived Bicyclic Amino Acids: Synthesis, Conformational Analysis and Construction of an αvB3-Selective RGD Peptide.

ChemInform ◽  
2010 ◽  
Vol 33 (30) ◽  
pp. no-no
Author(s):  
Francesco Peri ◽  
Roberta Bassetti ◽  
Enrico Caneva ◽  
Luca de Gioia ◽  
Barbara La Ferla ◽  
...  
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Rgd Peptide

Conformational Analysis of SomeC2-Symmetric Cyclic Peptides Containing Tetrahydrofuran Amino Acids†

2006 ◽  
Vol 71 (16) ◽  
pp. 6240-6243 ◽  
Author(s):  
Tushar Kanti Chakraborty ◽  
Saumya Roy ◽  
Dipankar Koley ◽  
Samit Kumar Dutta ◽  
Ajit Chand Kunwar
Keyword(s):  
Amino Acids ◽  
Conformational Analysis ◽  
Cyclic Peptides

Antiovulatory Potency and Conformation of an Antagonist of the Luteinizing Hormone-Releasing Hormone Having Six D-Amino Acids

1982 ◽  
Vol 37 (7) ◽  
pp. 872-876 ◽  
Author(s):  
Karl Folkers ◽  
Cyril Y. Bowers ◽  
Frank Momany ◽  
Klaus J. Friebel ◽  
Teresa Kubiak ◽  
...  
Keyword(s):  
Amino Acids ◽  
Luteinizing Hormone ◽  
Conformational Structure ◽  
Design Synthesis ◽  
Luteinizing Hormone Releasing Hormone ◽  
Energy Calculations ◽  
Releasing Hormone ◽  
Routes Of Administration ◽  
Antiovulatory Activity

Abstract [N-Ac-Thr 1 ,D-Phe 2,D-Trp 3,6]-LHRH was the model antagonist of LHRH, which was the basis for tho design, synthesis and bioassay of seven peptides having four, five and six D-amino acids, which resulted from three single, three double, and one triple introductions of D-amino acids in positions 4, 5 and 8 of the model. Only the analog with six D-amino acids, [N-Ac-Thr 1,D-Phe 2 ,D-Trp 3,D-Ser 4, D-Tyr 5 ,D-Trp 6 ,D-Arg 8]-LHRH, had antiovulatory activity which was higher than that of the model antagonist, i.e., 70% antiovulatory activity at 25 μg/rat compared with 50% activity at 50 μg/rat, respectively. Empirical energy calculations gave a conformational structure for [N-Ac-Thr 1,D-Phe 2,D-Trp 3, D-Ser 4,D-Tyr 5,D-Arg 6,D-Arg 8]-LHRH which is similar to that calculated for previous potent antagonists. These results are a basis of new designs of antagonists having D-sub-stituents in up to ten positions toward effective inhibitors of ovulation by the parenteral and oral routes of administration.

scholarly journals Design, Synthesis, and Conformational Analysis of Oligobenzanilides as Multifacial α-Helix Mimetics

2019 ◽  
Vol 21 (12) ◽  
pp. 4433-4438 ◽  
Author(s):  
Theo Flack ◽  
Charles Romain ◽  
Andrew J. P. White ◽  
Peter R. Haycock ◽  
Anna Barnard
Keyword(s):  
Conformational Analysis ◽  
Design Synthesis ◽  
Helix Mimetics ◽  
Α Helix
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