Lead Discovery of Quinoxalinediones as an Inhibitor of Dipeptidyl Peptidase-IV (DPP-IV) by High-Throughput Screening.

ChemInform ◽  
2004 ◽  
Vol 35 (38) ◽  
Author(s):  
Hyae-Gyeong Cheon ◽  
Chul-Min Lee ◽  
Beom-Tae Kim ◽  
Ki-Jun Hwang
Keyword(s):  
High Throughput ◽  
High Throughput Screening ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Lead Discovery ◽  
Dpp Iv

A high-throughput screening assay for dipeptidyl peptidase-IV inhibitors using human plasma

2021 ◽  
Author(s):  
Liwei Zou ◽  
Jing Zhang ◽  
Xingkai Qian ◽  
Peifang Song ◽  
Xiaodong Li ◽  
...  
Keyword(s):  
High Throughput Screening ◽  
Fluorescence Probe ◽  
Critical Role ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Screening Assay ◽  
Dpp Iv ◽  
High Throughput Screening Assay ◽  
Dipeptidyl Peptidase Iv Inhibitors ◽  
Two Photon Fluorescence

Dipeptidyl peptidase-IV (DPP-IV) plays a critical role in glucose metabolism and has become an important target for type 2 diabetes mellitus. We previously reported a two-photon fluorescence probe glycyl-prolyl-N-butyl-4-amino-1,8-naphthalimide (GP-BAN)...

Dipeptidyl Peptidase IV Inhibitors for Nonalcoholic Fatty Liver Disease – Systematic Review and Metanalysis

2020 ◽  
Vol 16 ◽  
Author(s):  
Lucas Ribeiro dos Santos ◽  
Marcio Luis Duarte ◽  
Maria Stella Peccin ◽  
Antônio Ricardo de Toledo Gagliardi ◽  
Tamara Melnik
Keyword(s):  
Hepatic Steatosis ◽  
Grey Literature ◽  
Specific Treatment ◽  
Reducing Power ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Cochrane Library ◽  
Vast Number ◽  
Dpp Iv ◽  
Dipeptidyl Peptidase Iv Inhibitors

Introduction:: Hepatic steatosis is a frequent condition, that afflicts, especially, obese and insulin resistant patients; diagnosis is made, usually, through imaging tests. Despite the high prevalence and risk of complications, there is no specific treatment approved, though a vast number of medications have been tested. Objective:: To determine the efficacy of dipeptidyl peptidase IV inhibitors (i DPP-IV) in the treatment of NAFLD. Methods:: We searched the electronic databases of the Cochrane Library, MEDLINE, EMBASE and LILACS, as well as reference lists of the included studies and grey literature; 9 studies were selected for inclusion. Results:: 7 studies were used for metanalysis, for 3 outcomes. i DPP-IV showed an ALT-reducing power of MD -10.83 [95% CI 35.23 to 13.57] at 3 months and MD -9.27 [95% CI 10.92 to -7.62] at 6 months of intervention, as well as reduction of hepatic steatosis via MRI of SMD 0.10 [95% CI 0.31 to 0.50]; the overall incidence of adverse events was very low. The studies were considered of low and very low quality by the GRADE evaluation. Conclusion:: Because of the poor overall quality of the studies and heterogeneity of the population analyzed, i DPP-IV did not show efficacy on inflammatory markers or fibrosis in patients with NAFLD.

scholarly journals Generation of wheat gluten hydrolysates with dipeptidyl peptidase IV (DPP-IV) inhibitory properties

2017 ◽  
Vol 8 (6) ◽  
pp. 2249-2257 ◽  
Author(s):  
A. B. Nongonierma ◽  
M. Hennemann ◽  
S. Paolella ◽  
R. J. FitzGerald
Keyword(s):  
Wheat Gluten ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Inhibitory Peptides ◽  
Dpp Iv

Wheat gluten hydrolysates contain known/potential DPP-IV inhibitory peptides.

Dipeptidyl peptidase IV (DPP-IV) inhibitory properties of a camel whey protein enriched hydrolysate preparation

2019 ◽  
Vol 279 ◽  
pp. 70-79 ◽  
Author(s):  
Alice B. Nongonierma ◽  
Cloé Cadamuro ◽  
Aurélien Le Gouic ◽  
Priti Mudgil ◽  
Sajid Maqsood ◽  
...  
Keyword(s):  
Whey Protein ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Dpp Iv

Effect of one week administration of dipeptidyl peptidase-IV inhibitory peptides from chum salmon milt on postprandial blood glucose level: a randomised, placebo-controlled, double-blind, crossover, pilot clinical trial

2021 ◽  
Author(s):  
Yoshinori Takahashi ◽  
Akira kamata ◽  
Mie Nishimura ◽  
Jun Nishihira
Keyword(s):  
Chum Salmon ◽  
Dipeptidyl Peptidase ◽  
Suppressive Effect ◽  
Dipeptidyl Peptidase Iv ◽  
Postprandial Blood Glucose ◽  
Sprague Dawley ◽  
Double Blind ◽  
Inhibitory Peptides ◽  
Dpp Iv ◽  
Postprandial Blood Glucose Level

Salmon milt peptide (SMP), an unused fish processing byproduct, exhibits strong inhibitory activity against dipeptidyl peptidase-IV (DPP-IV) and a suppressive effect on postprandial hyperglycaemia in Sprague–Dawley rats.Herein, we conducted a...

scholarly journals Wound Healing Process, Diabetes and Implications of Dipeptidyl Peptidase IV (DPP IV/CD26)

2017 ◽  
Vol 08 (03) ◽  
Author(s):  
Lara Baticic Pucar ◽  
Anja Kovac ◽  
Dijana Detel ◽  
Suncica ◽  
Ester Pernjak Pugel ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Wound Healing Process ◽  
Dpp Iv
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