A Facile Synthesis of Various Fluorine-Containing Indole Derivatives via Palladium-Catalyzed Annulation of Internal Alkynes.

ChemInform ◽  
2004 ◽  
Vol 35 (33) ◽  
Author(s):  
Jungha Chae ◽  
Tsutomu Konno ◽  
Takashi Ishihara ◽  
Hiroki Yamanaka
Keyword(s):  
Indole Derivatives ◽  
Facile Synthesis ◽  
Internal Alkynes ◽  
Palladium Catalyzed

A Facile Synthesis of Various Fluorine-Containing Indole Derivatives via Palladium-Catalyzed Annulation of Internal Alkynes

2004 ◽  
Vol 33 (3) ◽  
pp. 314-315 ◽  
Author(s):  
Jungha Chae ◽  
Tsutomu Konno ◽  
Takashi Ishihara ◽  
Hiroki Yamanaka
Keyword(s):  
Indole Derivatives ◽  
Facile Synthesis ◽  
Internal Alkynes ◽  
Palladium Catalyzed

ChemInform Abstract: Palladium-Catalyzed Carbonylative [3 + 2 + 1] Annulation of N-Aryl-pyridine-2-amines with Internal Alkynes by C-H Activation: Facile Synthesis of 2-Quinolinones.

ChemInform ◽  
2015 ◽  
Vol 46 (16) ◽  
pp. no-no
Author(s):  
Jianbin Chen ◽  
Kishore Natte ◽  
Anke Spannenberg ◽  
Helfried Neumann ◽  
Matthias Beller ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Internal Alkynes ◽  
Palladium Catalyzed

A facile synthesis of 2,3-disubstituted pyrrolo[2,3-b]pyridines via palladium-catalyzed heteroannulation with internal alkynes

1998 ◽  
Vol 39 (7) ◽  
pp. 627-630 ◽  
Author(s):  
Sang Sun Park ◽  
Joong-Kwon Choi ◽  
Eul Kgun Yum ◽  
Deok-Chan Ha
Keyword(s):  
Facile Synthesis ◽  
Internal Alkynes ◽  
Palladium Catalyzed

scholarly journals Divergent Synthesis of Indolenine and Indoline Ring Systems by Palladium-Catalyzed Asymmetric Dearomatization of Indoles

2021 ◽  
Author(s):  
Dong Gao ◽  
Lei Jiao
Keyword(s):  
Biologically Active ◽  
Indole Derivatives ◽  
Reaction Sequence ◽  
High Demand ◽  
Internal Alkynes ◽  
Palladium Catalyzed ◽  
Efficient Construction ◽  
Acidic Conditions ◽  
Semipinacol Rearrangement ◽  
Quaternary Stereocenter

Dearomatized indole derivatives bearing a C3- or C2-stereocenter exist ubiquitously in natural products and biologically active molecules. Despite remarkable advances in their chemical synthesis, stereoselective and regio-divergent methods are still in a high demand. Herein, a Pd-catalyzed intermolecular asymmetric spiroannulation of 2,3-disubstituted indoles with internal alkynes has been developed for the efficient construction of indoline structures with a C2-quaternary stereocenter. Stereospecific aza-semipinacol rearrangement of these indoline derivatives under acidic conditions afforded indolenine products bearing a C3-quaternary stereocenter, where the selectivity for the rearranging group could be controlled by the reaction sequence. The asymmetric spiroannulation together with the subsequent aza-semipinacol rearrangement enabled a divergent access to dearomatized indole derivatives with either a C3- or a C2-quaternary stereocenter.

Palladium-Catalyzed Carbonylative [3+2+1] Annulation ofN-Aryl-Pyridine-2-Amines with Internal Alkynes by CH Activation: Facile Synthesis of 2-Quinolinones

2014 ◽  
Vol 20 (44) ◽  
pp. 14189-14193 ◽  
Author(s):  
Jianbin Chen ◽  
Kishore Natte ◽  
Anke Spannenberg ◽  
Helfried Neumann ◽  
Matthias Beller ◽  
...  
Keyword(s):  
Facile Synthesis ◽  
Internal Alkynes ◽  
Palladium Catalyzed
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