Ionic Liquid Phase Organic Synthesis (IoLiPOS) Methodology Applied to the Three Component Preparation of 2-Thioxo Tetrahydropyrimidin-4-(1H)-ones under Microwave Dielectric Heating.

ChemInform ◽  
2004 ◽  
Vol 35 (32) ◽  
Author(s):  
Halima Hakkou ◽  
Jean Jacques Vanden Eynde ◽  
Jack Hamelin ◽  
Jean Pierre Bazureau
Keyword(s):  
Ionic Liquid ◽  
Liquid Phase ◽  
Organic Synthesis ◽  
Dielectric Heating ◽  
Microwave Dielectric ◽  
Microwave Dielectric Heating

scholarly journals Synthesis of 2-Substitued Indoles via Pd-Catalysed Cyclization in an Aqueous Micellar Medium

Molecules ◽  
2021 ◽  
Vol 26 (13) ◽  
pp. 3917
Author(s):  
Sofia Siciliano ◽  
Elena Cini ◽  
Maurizio Taddei ◽  
Giorgia Vinciarelli
Keyword(s):  
Water Environment ◽  
Delivery Mode ◽  
Micellar Medium ◽  
Dielectric Heating ◽  
Microwave Dielectric ◽  
Microwave Dielectric Heating ◽  
Heating Mode ◽  
Aqueous Micellar Medium ◽  
By Products ◽  
Better Than

The synthesis of 2-substituted indoles starting from the corresponding unprotected 2-alkynylanilines was made possible in 3% TPGS-750-M water using Pd(OAc)2 alone as the catalyst. The reaction was sensitive to the heating mode respect to the nature of the starting material as, in many cases, convectional heating was better than microwave dielectric heating. The MW (microwave) delivery mode had also an influence in the formation of by-products and, consequently, product yields. A tandem Sonogashira-cyclisation reaction was also accomplished using Pd(OAc)2/Xphos in the nanomicellar water environment.

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