scholarly journals Synthesis of Heparin Oligosaccharides.

ChemInform ◽  
2004 ◽  
Vol 35 (19) ◽  
Author(s):  
Jinq-Chyi Lee ◽  
Xin-An Lu ◽  
Suvarn S. Kulkarni ◽  
Yuh-Sheng Wen ◽  
Shang-Cheng Hung
Keyword(s):  
Heparin Oligosaccharides

Separation and Analysis of Nanomole Quantities of Heparin Oligosaccharides Using On-Line Capillary Isotachophoresis Coupled with NMR Detection

2005 ◽  
Vol 77 (18) ◽  
pp. 5998-6003 ◽  
Author(s):  
Albert K. Korir ◽  
Valentino K. Almeida ◽  
Douglas S. Malkin ◽  
Cynthia K. Larive
Keyword(s):  
Capillary Isotachophoresis ◽  
On Line ◽  
Heparin Oligosaccharides

scholarly journals The structure of heparin oligosaccharide fragments with high anti-(factor Xa) activity containing the minimal antithrombin III-binding sequence Chemical and13C nuclear-magnetic-resonance studies

1981 ◽  
Vol 197 (3) ◽  
pp. 599-609 ◽  
Author(s):  
B Casu ◽  
P Oreste ◽  
G Torri ◽  
G Zoppetti ◽  
J Choay ◽  
...  
Keyword(s):  
Uronic Acid ◽  
Antithrombin Iii ◽  
Factor Xa ◽  
Amino Sugar ◽  
Active Species ◽  
Model Compounds ◽  
High Affinity ◽  
The Common ◽  
Binding Sequence ◽  
Heparin Oligosaccharides

The chemical composition and the 13C n.m.r. spectra of heparin oligosaccharides (essentially octasaccharides), having high affinity for antithrombin III and high anti-(Factor Xa) activity, prepared by three independent approaches (extraction, partial deaminative cleavage with HNO2 and partial depolymerization with bacterial heparinase), leading to different terminal residues, have been studied and compared with those of the corresponding inactive species. Combined wit chemical data, the spectra of the active oligosaccharides and of their fragmentation products afforded information on composition and sequence. The three types of active oligosaccharides were shown to have the common hexasaccharide core I-Aa-G-As*-Is-As, where I and alpha-L-idopyranosyl-uronic acid, Aa = 2-acetamido-2-deoxy-alpha-D-glucopyranose, G = beta-D-glucopyranosyl-uronic acid, Is = alpha-L-idopyranosyluronic acid 2-O-sulphate, As = 2-deoxy-2-sulphamino-alpha-D-glucopyranose 6-O-sulphate. The fourth residue (As*) is an unusually substituted amino sugar resistant to mild deamination. The 13C spectra of the active species are characterized by signals from the above atypical amino sugar, the most evident of which is at 57.7 p.p.m. These signals, compared with those of appropriate synthetic model compounds, are compatible with the recently proposed 3-O-sulphation of the residue As* [Lindahl, Bäckström, Thunberg & Leder (1980) Proc. Natl. Acad. Sci. U.S.A. 77, 6551-6555].

Uncovering the detailed mode of cleavage of heparinase I toward structurally defined heparin oligosaccharides

2019 ◽  
Vol 141 ◽  
pp. 756-764
Author(s):  
Chengying Zhang ◽  
Fengyan Tang ◽  
Jingjing Zhang ◽  
Jichao Cao ◽  
Huijuan Li ◽  
...  
Keyword(s):  
Heparinase I ◽  
Heparin Oligosaccharides

Attenuation of glial scar formation in the injured rat brain by heparin oligosaccharides

2004 ◽  
Vol 49 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Noriko Hayashi ◽  
Seiji Miyata ◽  
Yutaka Kariya ◽  
Ryo Takano ◽  
Saburo Hara ◽  
...  
Keyword(s):  
Rat Brain ◽  
Glial Scar ◽  
Scar Formation ◽  
Heparin Oligosaccharides

scholarly journals Sequence analysis of heparan sulphate and heparin oligosaccharides

1999 ◽  
Vol 339 (3) ◽  
pp. 767 ◽  
Author(s):  
Romain R. VIVÈS ◽  
David A. PYE ◽  
Markku SALMIVIRTA ◽  
John J. HOPWOOD ◽  
Ulf LINDAHL ◽  
...  
Keyword(s):  
Sequence Analysis ◽  
Heparan Sulphate ◽  
Heparin Oligosaccharides

scholarly journals Enzymatic Preparation of Heparin Oligosaccharides Containing Antithrombin III Binding Sites

1996 ◽  
Vol 271 (50) ◽  
pp. 32040-32047 ◽  
Author(s):  
Toshihiko Toida ◽  
Ronald E. Hileman ◽  
April E. Smith ◽  
Petinka I. Vlahova ◽  
Robert J. Linhardt
Keyword(s):  
Binding Sites ◽  
Antithrombin Iii ◽  
Enzymatic Preparation ◽  
Heparin Oligosaccharides

scholarly journals Chemoenzymatic synthesis of unmodified heparin oligosaccharides: cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation

2017 ◽  
Vol 15 (5) ◽  
pp. 1222-1227 ◽  
Author(s):  
Xing Zhang ◽  
Yongmei Xu ◽  
Po-Hung Hsieh ◽  
Jian Liu ◽  
Lei Lin ◽  
...  
Keyword(s):  
Chemoenzymatic Synthesis ◽  
Natural Structure ◽  
Smith Degradation ◽  
Heparin Oligosaccharides

A heparin oligosaccharide having a completely natural structure was successfully synthesized through a chemoenzymatic approach using an unnatural glycosyl acceptor, p-nitrophenyl glucuronide (GlcA-pNP).

Modular Synthesis of Heparin Oligosaccharides.

ChemInform ◽  
2003 ◽  
Vol 34 (18) ◽  
Author(s):  
Hernan A. Orgueira ◽  
Alessandra Bartolozzi ◽  
Peter Schell ◽  
Remy E. J. N. Litjens ◽  
Emma R. Palmacci ◽  
...  
Keyword(s):  
Modular Synthesis ◽  
Heparin Oligosaccharides
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