IgE-Independent Activation of Human Mast Cells Indicates Their Role in the Late Phase Reaction of Allergic Inflammation

ChemInform ◽  
2004 ◽  
Vol 35 (18) ◽  
Author(s):  
A. Munitz ◽  
A. M. Piliponsky ◽  
F. Levi-Schaffer
Keyword(s):  
Mast Cells ◽  
Late Phase ◽  
Allergic Inflammation ◽  
Phase Reaction ◽  
Human Mast Cells ◽  
Late Phase Reaction

Conjunctival Mast Cells and the Allergic Late Phase Reaction

1992 ◽  
Vol 24 (4) ◽  
pp. 234-242 ◽  
Author(s):  
Andrea Leonardi ◽  
Antonio G. Secchi ◽  
Rebecca Briggs ◽  
Mathea R. Allansmith
Keyword(s):  
Mast Cells ◽  
Late Phase ◽  
Phase Reaction ◽  
Late Phase Reaction

scholarly journals Immunoglobulin E plus antigen challenge induces a novel intercrine/chemokine in mouse mast cells.

1992 ◽  
Vol 176 (6) ◽  
pp. 1773-1778 ◽  
Author(s):  
P A Kulmburg ◽  
N E Huber ◽  
B J Scheer ◽  
M Wrann ◽  
T Baumruker
Keyword(s):  
Mast Cell ◽  
Mast Cells ◽  
Immunoglobulin E ◽  
Late Phase ◽  
Antigen Challenge ◽  
Pcr Analysis ◽  
Phase Reaction ◽  
Late Phase Reaction ◽  
Mouse Tissues ◽  
Peritoneal Mast Cells

In an attempt to characterize genes participating in the allergic late phase reaction, we have isolated a novel intercrine/chemokine (called MARC) from a cDNA library of the stimulated mouse mast cell line, CPII. As measured by Northern blotting, it is strongly upregulated at the mRNA level after the physiological challenge of the cells with immunoglobulin (Ig)E plus antigen. Unstimulated cells completely lack significant, stable expression, as do a number of other, different cell lines (uninduced and induced) and mouse tissues. In contrast to the Northern blot analysis, a polymerase chain reaction (PCR) analysis, performed on CPII cells and on Percoll gradient purified mouse peritoneal mast cells, revealed a basal level of transcription in the uninduced stage. After 2 h of IgE plus antigen challenge, a quantitative reverse transcriptase-PCR, using a spiked in MIMIC, showed a level of transcripts more than 100-fold higher in the CPII cells and 5-20-fold higher in purified mouse peritoneal cavity mast cells. This rapid induction after the Fc epsilon RI challenge, the identification of the gene as a member of the chemokine family, and its upregulated expression in peritoneal mast cells, all suggest an involvement in certain acute and chronic pathological mast cell-driven diseases.

Childhood Asthma: Overview

1989 ◽  
Vol 10 (8) ◽  
pp. 227-233
Author(s):  
M. J. Goldenhersh ◽  
Gary S. Rachelefsky
Keyword(s):  
Childhood Asthma ◽  
Chronic Cough ◽  
Late Phase ◽  
Inflammatory Cells ◽  
Polymorphonuclear Cells ◽  
Phase Reaction ◽  
Recurrent Pneumonia ◽  
Late Phase Reaction ◽  
Airway Response ◽  
Trachea And Bronchi

DEFINITION Asthma is a syndrome characterized by increased responsiveness of the trachea and bronchi to various stimuli and is manifested by widespread reversible narrowing of the airways that changes in severity either spontaneously or as a result of therapy.1 The hyperresponsiveness ("twitchiness") of airways is a fundamental abnormality and is dynamic in nature. Asthma is a disease of persistent or recurrent airway inflammation characterized by the presence of inflammatory cells (eosinophils and polymorphonuclear cells), edema of the wall, and changes in epithelial cells. Airway response to allergens and certain irritants may be acute (occurring within minutes to one hour following exposure), delayed or late (occurring within four to eight hours following exposure), or dual (combination of acute and late phase). Some reactions are only delayed. The late phase reaction is largely attributed to ongoing inflammation. Because of the variability of its presentation (complete v partial reversibility of airways obstruction, hyperreactivity accompanying other respiratory disease, chronic cough, or recurrent pneumonia with or without wheeze), children have often been denied appropriate antiasthmatic medications and their symptoms have been attributed instead to "wheezy bronchitis," "recurrent bronchiolitis," "spastic bronchitis," or "wheezy baby syndrome." For years pediatricians have been schooled to approach the wheezing child skeptically ("all that wheezes is not asthma").

scholarly journals IL-9+ IL-10+ T cells link immediate allergic response to late phase reaction

2011 ◽  
Vol 165 (1) ◽  
pp. 29-37 ◽  
Author(s):  
S.-H. He ◽  
Z.-Q. Liu ◽  
X. Chen ◽  
C.-H. Song ◽  
L.-F. Zhou ◽  
...  
Keyword(s):  
T Cells ◽  
Late Phase ◽  
Allergic Response ◽  
Phase Reaction ◽  
Late Phase Reaction

Eosinophil infiltration into human skin is antigen-dependent in the late-phase reaction

1996 ◽  
Vol 134 (6) ◽  
pp. 997-1004 ◽  
Author(s):  
T.M. LITCHFIELD ◽  
C.H. SMITH ◽  
B.A. ATKINSON ◽  
P.G. NORRIS ◽  
P. ELLIOTT ◽  
...  
Keyword(s):  
Human Skin ◽  
Late Phase ◽  
Eosinophil Infiltration ◽  
Phase Reaction ◽  
Late Phase Reaction
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