Efficient Preparation of Three Building Blocks for the Synthesis of Heparan Sulfate Fragments: Towards the Combinatorial Synthesis of Oligosaccharides from Hypervariable Regions.

ChemInform ◽  
2004 ◽  
Vol 35 (1) ◽  
Author(s):  
Ollivier Gavard ◽  
Yael Hersant ◽  
Jocelyne Alais ◽  
Veronique Duverger ◽  
Anna Dilhas ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Building Blocks ◽  
Combinatorial Synthesis ◽  
Hypervariable Regions

scholarly journals Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

2019 ◽  
Vol 17 (7) ◽  
pp. 1817-1821 ◽  
Author(s):  
Darshita Budhadev ◽  
Karinna Saxby ◽  
Julia Walton ◽  
Gideon Davies ◽  
Peter C. Tyler ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Building Blocks ◽  
Practical Synthesis

Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks.

Novel Type of Rigid C-Linked Glycosylacetylene−Phenylalanine Building Blocks for Combinatorial Synthesis of C-linked Glycopeptides

1998 ◽  
Vol 63 (26) ◽  
pp. 9657-9668 ◽  
Author(s):  
Todd Lowary ◽  
Morten Meldal ◽  
Arnim Helmboldt ◽  
Andrea Vasella ◽  
Klaus Bock
Keyword(s):  
Building Blocks ◽  
Combinatorial Synthesis

Assembly of glycoamino acid building blocks: a new strategy for the straightforward synthesis of heparan sulfate mimics

2018 ◽  
Vol 54 (95) ◽  
pp. 13455-13458 ◽  
Author(s):  
Julia Revuelta ◽  
Roberto Fuentes ◽  
Laura Lagartera ◽  
María José Hernáiz ◽  
Agatha Bastida ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Building Blocks ◽  
New Class ◽  
New Strategy

We report on a new class of linear heparan sulfate mimics prepared by the assembly of glycoaminoacid building blocks.

scholarly journals Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

2019 ◽  
Vol 58 (51) ◽  
pp. 18577-18583 ◽  
Author(s):  
Nitin J. Pawar ◽  
Lei Wang ◽  
Takuya Higo ◽  
Chandrabali Bhattacharya ◽  
Pavan K. Kancharla ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Building Blocks

ChemInform Abstract: Novel Type of Rigid C-Linked Glycosylacetylene-Phenylalanine Building Blocks for Combinatorial Synthesis of C-Linked Glycopeptides.

ChemInform ◽  
2010 ◽  
Vol 30 (22) ◽  
pp. no-no
Author(s):  
Todd Lowary ◽  
Morten Meldal ◽  
Arnim Helmboldt ◽  
Andrea Vasella ◽  
Klaus Bock
Keyword(s):  
Building Blocks ◽  
Combinatorial Synthesis

scholarly journals Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly

2019 ◽  
Vol 131 (51) ◽  
pp. 18750-18756
Author(s):  
Nitin J. Pawar ◽  
Lei Wang ◽  
Takuya Higo ◽  
Chandrabali Bhattacharya ◽  
Pavan K. Kancharla ◽  
...  
Keyword(s):  
Heparan Sulfate ◽  
Building Blocks

Creating chemical diversity space by scaffold decoration of dihydropyrimidines

2005 ◽  
Vol 77 (1) ◽  
pp. 155-161 ◽  
Author(s):  
Doris Dallinger ◽  
C. Oliver Kappe
Keyword(s):  
Drug Discovery ◽  
Driving Force ◽  
New Technologies ◽  
Materials Science ◽  
Building Blocks ◽  
Chemical Diversity ◽  
Combinatorial Synthesis ◽  
Biologically Active ◽  
Compound Libraries

The demand for diverse compound libraries for screening in drug discovery and materials science is the driving force behind the development of new technologies for rapid parallel and combinatorial synthesis. The focus of this article will be on the scaffold decoration of biologically active dihydropyrimidines (DHPMs) of the Biginelli type, exploring the diversity on all six positions around the scaffold. This opens up the generation of a very large number of analogs given the commercial availability of the building blocks that are used in the functionalization process.

Thiazole and oxazole building blocks for combinatorial synthesis

1999 ◽  
Vol 40 (45) ◽  
pp. 7951-7953 ◽  
Author(s):  
Lenore M. Martin ◽  
Bi-Huang Hu
Keyword(s):  
Building Blocks ◽  
Combinatorial Synthesis
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