Industrial Application of Enantioselective Hydrogenation: Where Do You Get the Chiral Catalyst?

ChemInform ◽  
2003 ◽  
Vol 34 (27) ◽  
Author(s):  
Marc Thommen ◽  
Hans-Ulrich Blaser
Keyword(s):  
Industrial Application ◽  
Enantioselective Hydrogenation ◽  
Chiral Catalyst

Continuous enantioselective hydrogenation of activated ketones on a pt-cd chiral catalyst: use of h-cube reactor system

2006 ◽  
Vol 88 (2) ◽  
pp. 391-398 ◽  
Author(s):  
György Szöllősi ◽  
Beáta Hermán ◽  
Ferenc Fülöp ◽  
and Mihály Bartók
Keyword(s):  
Enantioselective Hydrogenation ◽  
Reactor System ◽  
Chiral Catalyst

Enantioselective hydrogenation of dehydro-amino ac acid derivatives using pindophos-rhodium as chiral catalyst

1996 ◽  
Vol 7 (4) ◽  
pp. 1011-1018 ◽  
Author(s):  
Hans-Jörn Kreuzfeld ◽  
Ute Schmidt ◽  
Christian Döbler ◽  
Hans Walter Krause
Keyword(s):  
Enantioselective Hydrogenation ◽  
Chiral Catalyst

Enantioselective Synthesis of Epi-Emetine Analogues: Control of the Facial Selectivity in a Three-Component Domino Knoevenagel-Hetero-Diels-Alder Reaction*

2004 ◽  
Vol 59 (4) ◽  
pp. 468-477 ◽  
Author(s):  
Lutz F. Tietze ◽  
Nils Rackelmann
Keyword(s):  
Main Product ◽  
Enantioselective Hydrogenation ◽  
Alder Reaction ◽  
Diels Alder ◽  
Enantioselective Synthesis ◽  
Enol Ether ◽  
Meldrum’S Acid ◽  
Chiral Catalyst ◽  
Diels Alder Reaction ◽  
Facial Selectivity

AbstractThe domino Knoevenagel-hetero-Diels-Alder reaction of the aldehyde rac-8, Meldrum’s acid 2 and enol ether 3 leads to the cycloadduct rac-17 as the main product which in a second domino process was transformed into the benzoisoquinolizidine rac-18 by solvolysis, hydrogenolysis, condensation and hydrogenation; rac-18 was used as a substrate for the synthesis of the two diastereomeric epiemetine analogues 9 and 10 with > 96% ee (9) and 80% ee (10), respectively, by condensation with the phenylethylamine 23, Bischler-Napieralski reaction and “enantioselective” hydrogenation using the chiral catalyst (R,R)-26.

Fine Chemicals Synthesis by Heterogeneous Asymmetric Catalysis

1994 ◽  
Vol 368 ◽  
Author(s):  
Kam T. Wan ◽  
Mark E. Davis
Keyword(s):  
Asymmetric Synthesis ◽  
Asymmetric Catalysis ◽  
Industrial Application ◽  
Antiinflammatory Drug ◽  
Fine Chemicals ◽  
Chiral Catalyst ◽  
Heterogeneous Asymmetric Catalysis

ABSTRACTThe application of heterogeneous asymmetric catalysis to fine chemicals synthesis is discussed. The asymmetric synthesis of naproxen, a non-steroidal antiinflammatory drug, using a novel, heterogeneous, chiral catalyst is used as an example to illustrate the feasibility to industrial application.

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