Synthesis and Preliminary Cytotoxicity of Nitrogen Mustard Derivatives of Distamycin A.

ChemInform ◽  
2003 ◽  
Vol 34 (21) ◽  
Author(s):  
Yuqiang Wang ◽  
Susan C. Wright ◽  
James W. Larrick
Keyword(s):  
Nitrogen Mustard ◽  
Distamycin A ◽  
Derivatives Of

Synthesis and preliminary cytotoxicity of nitrogen mustard derivatives of distamycin A

2003 ◽  
Vol 13 (3) ◽  
pp. 459-461 ◽  
Author(s):  
Yuqiang Wang ◽  
Susan C Wright ◽  
James W Larrick
Keyword(s):  
Nitrogen Mustard ◽  
Distamycin A ◽  
Derivatives Of

Novel benzoyl nitrogen mustard derivatives of pyrazole analogues of distamycin A: synthesis and antileukemic activity

1999 ◽  
Vol 7 (2) ◽  
pp. 251-262 ◽  
Author(s):  
Pier Giovanni Baraldi ◽  
Paolo Cozzi ◽  
Cristina Geroni ◽  
Nicola Mongelli ◽  
Romeo Romagnoli ◽  
...  
Keyword(s):  
Nitrogen Mustard ◽  
Antileukemic Activity ◽  
Distamycin A ◽  
Derivatives Of

Novel phenyl nitrogen mustard and half-mustard derivatives of distamycin A

1997 ◽  
Vol 7 (23) ◽  
pp. 2985-2990 ◽  
Author(s):  
Paolo Cozzi ◽  
Italo Beria ◽  
Giovanni Biasoli ◽  
Marina Caldarelli ◽  
Laura Capolongo ◽  
...  
Keyword(s):  
Nitrogen Mustard ◽  
Distamycin A ◽  
Derivatives Of

The Synthesis of Some Aryl Nitrogen Mustard Derivatives of Estrogens

1967 ◽  
Vol 10 (2) ◽  
pp. 255-257 ◽  
Author(s):  
C. R. Walk ◽  
T. C. Chou ◽  
Hsi Hu. Lin
Keyword(s):  
Nitrogen Mustard ◽  
Derivatives Of

Protection of L-cells by thiols against the toxicity of sulfur mustard

1969 ◽  
Vol 47 (2) ◽  
pp. 143-151 ◽  
Author(s):  
I. G. Walker ◽  
J. F. Smith
Keyword(s):  
Nitrogen Mustard ◽  
Sulfur Mustard ◽  
Lethal Effect ◽  
Protective Mechanism ◽  
Protective Activity ◽  
L Cells ◽  
Alkyl Derivatives ◽  
Cellular Dna ◽  
Derivatives Of

The lethal effect of sulfur mustard on L-cells was reduced by pretreating the cells with dithiothreitol (DTT), aminoethylisothiuronium bromide, mercaptoethylamine, and some alkyl derivatives of this compound. The disulfides of these agents were without protective activity. The protective mechanism by which DTT operated involved a simple inactivation of the sulfur mustard. This deduction was based on the finding that alkylation by mustard of cellular DNA, RNA, and protein was reduced by DTT treatment in parallel with the reduction in toxicity of the mustard. DTT at a tolerated dose of 100 mg/kg provided scant protection to mice against the nitrogen mustard HN2.

Novel phenyl nitrogen mustard and half-mustard derivatives of amidino-modified distamycin

1997 ◽  
Vol 7 (23) ◽  
pp. 2979-2984 ◽  
Author(s):  
Paolo Cozzi ◽  
Italo Beria ◽  
Giovanni Biasoli ◽  
Marina Caldarelli ◽  
Laura Capolongo ◽  
...  
Keyword(s):  
Nitrogen Mustard ◽  
Derivatives Of

Liposomes and Micellar Dispersions For Delivery of Benzoheterocyclic Derivatives of Distamycin A

Drug Delivery ◽  
2007 ◽  
Vol 14 (1) ◽  
pp. 1-8 ◽  
Author(s):  
R. Cortesi ◽  
E. Esposito ◽  
I. Cuccu ◽  
R. Romagnoli ◽  
E. Menegatti ◽  
...  
Keyword(s):  
Distamycin A ◽  
Derivatives Of
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