Total Synthesis of Cobyric Acid: Historical Development and Recent Synthetic Innovations

ChemInform ◽  
2003 ◽  
Vol 34 (16) ◽  
Author(s):  
Doris Riether ◽  
Johann Mulzer
Keyword(s):  
Total Synthesis ◽  
Historical Development ◽  
Cobyric Acid

Total synthesis of vitamin B12 — a fellowship of the ring

2016 ◽  
Vol 20 (01n04) ◽  
pp. 1-20 ◽  
Author(s):  
G. Wayne Craig
Keyword(s):  
Total Synthesis ◽  
Vitamin B12 ◽  
Cyclic Ether ◽  
Vitamin B ◽  
Porphyrin Molecule ◽  
Cobyric Acid

In the synthesis of cobyric acid following an arduous 60-step synthesis of the tetrapyrrole corrigenolide, Woodward demonstrated that ring cyclization yielded unexpectedly the corrin cyclic ether (Fig. 2). Its structure was chosen as the chemistry logo for the 1970 IUPAC meeting. It was a reminder that chemistry can be capricious and beautiful. This article is a tribute to the 50-year career in porphyrins of Professor Kevin M. Smith and describes his early contributions with colleagues in the synthetic quest of a related porphyrin molecule, vitamin B12 (Fig. 1a).

Total synthesis of Δ9(12)-capnellene-8α,10α-diol

1982 ◽  
Vol 23 (52) ◽  
pp. 5471-5474
Author(s):  
G Pattenden
Keyword(s):  
Total Synthesis

Total synthesis of melleumins A and B and their analogs: Determination of stereochemistry and Wnt signal inhibitory activity

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
M Ishibashi ◽  
S Hanazawa ◽  
Y Uchino ◽  
X Li ◽  
MA Arai
Keyword(s):  
Total Synthesis ◽  
Inhibitory Activity ◽  
Wnt Signal

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product
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