ChemInform Abstract: Discovery of the Cross-Coupling Reaction Between Grignard Reagents and C(sp2) Halides Catalyzed by Nickel-Phosphine Complexes.

ChemInform ◽  
2010 ◽  
Vol 33 (39) ◽  
pp. no-no
Author(s):  
Kohei Tamao
Keyword(s):  
Coupling Reaction ◽  
Cross Coupling ◽  
Grignard Reagents ◽  
Phosphine Complexes ◽  
Cross Coupling Reaction ◽  
The Cross ◽  
Nickel Phosphine

Cross-coupling Reaction of Grignard Reagents with Alkyl Halides Catalyzed by Green, Economical Copper Bromide Catalyst

2011 ◽  
Vol 233-235 ◽  
pp. 1119-1122 ◽  
Author(s):  
Zhi Qun Dai ◽  
Zhi Yong Zhang ◽  
Wei Wei Zhang ◽  
Ben Mei Wei
Keyword(s):  
Catalytic Activity ◽  
Alkyl Halide ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Systematic Research ◽  
Cross Coupling Reaction ◽  
The Cross ◽  
Electron Withdrawing Group

For the first time a systematic research on the catalytic activity of CuXn(X=Cl, Br, I; x=1,2) for the cross-coupling reaction of alkyl halides with Grignard reagents was carried out and environmentally friendly, economical CuBr2showed highest catalytic activity among the catalyst. The conditions of the cross-coupling reaction were studied. The suitable amount of catalyst, reaction temperature and time are 0.3% mol (based on alkyl halide), 67°C (reflux), 6 h, respectively. Under the optimal conditions, the yields of the cross-coupling could reach up to 93%. Moreover, Grignard reagent with an electron-rich group reacted rapidly and with an electron-withdrawing group reacted sluggishly.

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