ChemInform Abstract: Synthetic Studies of Yessotoxin, a Polycyclic Ether Implicated in Diarrhetic Shellfish Poisoning: Convergent Synthesis of the BCDE Ring System (I) via an Alkyne Intermediate.

ChemInform ◽  
2010 ◽  
Vol 33 (29) ◽  
pp. no-no
Author(s):  
Yuji Mori ◽  
Hisafumi Hayashi
Keyword(s):  
Ring System ◽  
Shellfish Poisoning ◽  
Diarrhetic Shellfish Poisoning ◽  
Convergent Synthesis ◽  
Synthetic Studies ◽  
Polycyclic Ether

ChemInform Abstract: Synthetic Studies on Ciguatoxin: A Highly Convergent Synthesis of the GHIJKLM Ring System (I) Based on B-Alkyl Suzuki Coupling.

ChemInform ◽  
2010 ◽  
Vol 32 (27) ◽  
pp. no-no
Author(s):  
Hiroyuki Takakura ◽  
Katsuhiko Noguchi ◽  
Makoto Sasaki ◽  
Kazuo Tachibana
Keyword(s):  
Suzuki Coupling ◽  
Ring System ◽  
Convergent Synthesis ◽  
Synthetic Studies

Development of Certified Reference Materials for Diarrhetic Shellfish Poisoning Toxins, Part 2: Shellfish Matrix Materials

2016 ◽  
Vol 99 (5) ◽  
pp. 1163-1172 ◽  
Author(s):  
Pearse McCarron ◽  
Kelley L Reeves ◽  
Sabrina D Giddings ◽  
Daniel G Beach ◽  
Michael A Quilliam
Keyword(s):  
Reference Materials ◽  
Matrix Effects ◽  
Certified Reference Materials ◽  
Standard Addition ◽  
Tissue Homogenate ◽  
Shellfish Poisoning ◽  
Diarrhetic Shellfish Poisoning ◽  
Preliminary Work ◽  
Seafood Industry ◽  
Human Illness

Abstract Okadaic acid (OA) and its analogs, dinophysistoxins-1 (DTX1) and -2 (DTX2) are lipophilic biotoxins produced by marine algae that can accumulate in shellfish and cause the human illness known as diarrhetic shellfish poisoning (DSP). Regulatory testing of shellfish is required to protect consumers and the seafood industry. Certified reference materials (CRMs) are essential for the development, validation, and quality control of analytical methods, and thus play an important role in toxin monitoring. This paper summarizes work on research and development of shellfish tissue reference materials for OA and DTXs. Preliminary work established the appropriate conditions for production of shellfish tissue CRMs for OA and DTXs. Source materials, including naturally incurred shellfish tissue and cultured algae, were screened for their DSP toxins. This preliminary work informed planning and production of a wet mussel (Mytilus edulis) tissue homogenate matrix CRM. The homogeneity and stability of the CRM were evaluated and found to be fit-for-purpose. Extraction and LC-tandem MS methods were developed to accurately certify the concentrations of OA, DTX1, and DTX2 using a combination of standard addition and matrix-matched calibration to compensate for matrix effects in electrospray ionization. The concentration of domoic acid was also certified. Uncertainties were assigned following standards and guidelines from the International Organization for Standardization. The presence of other toxins in the CRM was also assessed and information values are reported for OA and DTX acyl esters.

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